Protein Alignment SNX18 and VPS17

DIOPT Version :10

• Sequence 1: XP_047272635.1
• Gene: SNX18 / 112574
• HGNCID: 19245
• Length: 659
• Species: Homo sapiens
• Sequence 2: NP_014775.3
• Gene: VPS17 / 854300
• SGDID: S000005658
• Length: 551
• Species: Saccharomyces cerevisiae
• Alignment Length: 530
• Identity: 110/530 - (20%)
• Similarity: 183/530 - (34%)
• Gaps: 152/530 - (28%)

Human   152 DDWDDEWDDSSTVAD------EPGALGSGAYPDLDGSSSAGVGAAGRYRLSTRSDLSLGSRGGSV 210
            |.:||.  |::..|:      ||.|..:      |||||     ....|:.|....:.....|:.
Yeast     8 DPYDDL--DNNPFAEPQEEDSEPAATTT------DGSSS-----MSEERVGTEQTAASVQDNGTA 59

Human   211 PPQHHPSGPKSSATVSRNLNRFSTFVKSG--GEAFVLGEASGFVKDGDKLCVVLG--PYGPEW-- 269
            ....:..|.:.:||.|:..|..:...:..  .|..:|.|.|...|....|..|.|  .:|...
Yeast    60 NNIQNGLGEEGNATRSKTSNEHNENQQPSQPSERVILPERSDEKKKYTLLAKVTGLERFGSATGK 124

Human   270 QENP-YPFQCTIDDPT-KQTKFKGMKSYISYKLVPTHTQVPVHRRYKHFDWLYARLAEKFPVISV 332
            :||| ..|.|:.:.|| ::.::|.:|.  ||:        ..|:.:|   :|...:.|.|    |
Yeast   125 KENPTIIFDCSTNLPTFRKQQYKNVKK--SYE--------EFHQLFK---YLNVAIQESF----V 172

Human   333 PHLPEKQATG--RFEEDFISKRRKGLIWWMNHMASHPVLAQCDVFQHFLTCPSST-----DEKAW 390
            |.||....|.  ..|||.:...|...:|: |.::..|::.:.:....|:....:|     ..|:.
Yeast   173 PTLPSAYTTFGINSEEDRMKVTRNFQLWF-NRLSQDPLIIRNEEVAFFIESDFNTYTPINKSKSL 236

Human   391 KQG-KRKAEKDEMVGANFFLTLSTPPAAALDLQEVESKIDGFKCFTKKMDDSALQLNHTANEFAR 454
            ..| |||..|.          |:.|.....:|.|....:......::.:.:..|:::..     |
Yeast   237 ASGLKRKTLKQ----------LAPPYDEITELAEFRPLVKSIYVVSQSLQEKLLRVSRN-----R 286

Human   455 KQVTGFKKEYQKVGQSFRGLSQAFELDQQAFSVGLNQAIAFTGDAYDAIGELFAEQPRQDLDPV- 518
            |.:.   :|....||.|      ..||:.      |:.....|....|:|         |:|.:
Yeast   287 KMMV---QEENAFGQDF------VNLDEH------NKLYRRYGKILTAVG---------DIDSII 327

Human   519 --MDLLALYQG-------------HLAN----FPDIIHVQKGKAWPLEQV-------------IW 551
              ||:..||.|             .|.|    ..:::..|:......||.             |.
Yeast   328 ATMDMATLYDGLEWIVRDAYAVKEALTNRHFIMRNLVQAQQNSKAKQEQARRFRSRRDINPMKID 392

Human   552 SVLCRLKGATLTAVPL------------------------WVSESYSTGALTKVKESRRH---VE 589
            ..|.:||.|......|                        |:..|.....|.|::..|:.   :|
Yeast   393 EALRQLKAAAKNEQVLTLKLQRITSNMIIERKQWISWYEEWIRSSIKEFTLRKIEYERKKLTLLE 457

Human   590 EGKMEVQKAD 599
            ..:.:::|||
Yeast   458 RVRSDIRKAD 467

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SNX18	XP_047272635.1	SH3_SNX18	4..58	CDD:212830
		PHA01929	<81..>138	CDD:177328
		PX_SNX18	276..403	CDD:132819	33/135 (24%)
		BAR_SNX18	415..656	CDD:153354	42/245 (17%)
VPS17	NP_014775.3	PX_Vps17p	85..223	CDD:132801	38/155 (25%)
		BAR_Vps17p	239..462	CDD:153309	46/261 (18%)