Protein Alignment SNX18 and VPS5

DIOPT Version :10

• Sequence 1: XP_047272635.1
• Gene: SNX18 / 112574
• HGNCID: 19245
• Length: 659
• Species: Homo sapiens
• Sequence 2: NP_014712.2
• Gene: VPS5 / 854235
• SGDID: S000005595
• Length: 675
• Species: Saccharomyces cerevisiae
• Alignment Length: 478
• Identity: 103/478 - (21%)
• Similarity: 172/478 - (35%)
• Gaps: 128/478 - (26%)

Human   228 NLNRFSTFVKSGGEAFVLGEASGFVKDGDKLCVVLGPYGPEWQENPYPFQCTIDDPTKQTKFKGM 292
            ||.:....:.|..|.....|..|..|.|.|:        |. .|....|:..:.||.|..:...:
Yeast   242 NLPQTGANISSPAEVEENSEKFGKTKIGSKV--------PP-TEKAVAFKVEVKDPVKVGELTSI 297

Human   293 KSYISYKLVPTHT-----QVPVHRRYKHFDWLYARLAEKFPVISVPHLPEKQATGRFEEDFISKR 352
              ::.|.::...:     ...|.|||:.|.|||.:|........:|..||||:.|.|:|:||..|
Yeast   298 --HVEYTVISESSLLELKYAQVSRRYRDFRWLYRQLQNNHWGKVIPPPPEKQSVGSFKENFIENR 360

Human   353 RKGLIWWMNHMASHPVLAQCDVFQHFLTCPSSTDEKAWKQGKRKAEKDEMVGANFFLTLSTPPAA 417
            |..:...:..:...|||.:...|..|||....:.|     .|::|          |||.|.....
Yeast   361 RFQMESMLKKICQDPVLQKDKDFLLFLTSDDFSSE-----SKKRA----------FLTGSGAIND 410

Human   418 ALDLQEVE-SKI-------------------DGFKCFTKKMDDSALQLNHTANEFARKQVTGFKK 462
            :.||.||. |:|                   :..|.| ..:..|:|...:.|:||       |.:
Yeast   411 SNDLSEVRISEIQLLGAEDAAEVLKNGGIDAESHKGF-MSISFSSLPKYNEADEF-------FIE 467

Human   463 EYQKVGQ---SFRGLSQAFELDQQAFSVGLNQAIAFT---GDAYDAIGELFAEQPRQDLDPVMDL 521
            :.||:.:   :.:.||::.|:    .....|...|.|   ....:.:..|...:|..:|
Yeast   468 KKQKIDELEDNLKKLSKSLEM----VDTSRNTLAASTEEFSSMVETLASLNVSEPNSEL------ 522

Human   522 LALYQGHLANFPDI---IHVQKGKAWPLEQVIWSVLCRLKGATLTAVPLWVSESYSTGALTKVKE 583
                   |.||.|:   |.....::...|.:...|:......:|.:|....::....|....|.|
Yeast   523 -------LNNFADVHKSIKSSLERSSLQETLTMGVMLDDYIRSLASVKAIFNQRSKLGYFLVVIE 580

Human   584 ---SRRHVEEGKM----------EVQK-------------------ADGIQDRCNTISFATLAEI 616
               :::|.:.||:          |::|                   .|.|:|           |.
Yeast   581 NDMNKKHSQLGKLGQNIHSEKFREMRKEFQTLERRYNLTKKQWQAVGDKIKD-----------EF 634

Human   617 HHFHQIRVRDFKSQMQHFLQQQI 639
            ..|...::|:|::.|:..|:..|
Yeast   635 QGFSTDKIREFRNGMEISLEAAI 657

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SNX18	XP_047272635.1	SH3_SNX18	4..58	CDD:212830
		PHA01929	<81..>138	CDD:177328
		PX_SNX18	276..403	CDD:132819	36/131 (27%)
		BAR_SNX18	415..656	CDD:153354	52/286 (18%)
VPS5	NP_014712.2	PX_Vps5p	281..390	CDD:132771	33/110 (30%)
		BAR_Vps5p	460..673	CDD:153311	42/233 (18%)