Protein Alignment SNX18 and snx18a

DIOPT Version :10

• Sequence 1: XP_047272635.1
• Gene: SNX18 / 112574
• HGNCID: 19245
• Length: 659
• Species: Homo sapiens
• Sequence 2: NP_001093476.1
• Gene: snx18a / 562372
• ZFINID: ZDB-GENE-070705-339
• Length: 567
• Species: Danio rerio
• Alignment Length: 661
• Identity: 435/661 - (65%)
• Similarity: 493/661 - (74%)
• Gaps: 98/661 - (14%)

Human     1 MALRARALYDFRSENPGEISLREHEVLSLCSEQDIEGWLEGVNSRGDRGLFPASYVQVIRAPEPG 65
            |||||||||||.||||||||::|:|:::|.|||||||||||.||||.|||.|||||:::|.....
Zfish     1 MALRARALYDFNSENPGEISVKENEIVTLYSEQDIEGWLEGTNSRGARGLLPASYVEILRNDTVS 65

Human    66 PAGDGGPGAPARYANVPPGGFEPLPVAPPASFKPPPDAFQALLQPQQAPPPSTFQPPGAGFPYGG 130
            ...:.     :||||||.|.||.....|.::|    .|:.||.|.||...|
Zfish    66 SFNNN-----SRYANVPTGAFESFNSTPASTF----SAYPALPQQQQQQQP-------------- 107

Human   131 GALQPSPQQLYGGYQASQGSDDDWDDEWDDSSTVADEPGALGSGAYPDLDGSSSAGVGAAGRYRL 195
                         :|.:..|||||||:|||.|::|||||.:| |.|.:.:|:..:|      |.:
Zfish   108 -------------HQGTPASDDDWDDDWDDHSSIADEPGVVG-GGYRNYEGNGPSG------YSI 152

Human   196 STRSDLSLGSRGGSVPPQHHPSG---PKSSATVSRNLNRFSTFVKSGGEAFVLGEASGFVKDGDK 257
            ||.|               .|.|   .||||||||||||||||||||||||||||||||||||||
Zfish   153 STSS---------------MPRGAQQAKSSATVSRNLNRFSTFVKSGGEAFVLGEASGFVKDGDK 202

Human   258 LCVVLGPYGPEWQENPYPFQCTIDDPTKQTKFKGMKSYISYKLVPTHTQVPVHRRYKHFDWLYAR 322
            :|||:|.||||||||||||.|||||||||||||||||||||||.|||||..|:||||||||||||
Zfish   203 ICVVMGQYGPEWQENPYPFSCTIDDPTKQTKFKGMKSYISYKLTPTHTQSQVNRRYKHFDWLYAR 267

Human   323 LAEKFPVISVPHLPEKQATGRFEEDFISKRRKGLIWWMNHMASHPVLAQCDVFQHFLTCPSSTDE 387
            |.||||||||||:||||||||||||||||||:|||||||||.||||||:||||||||:| |||||
Zfish   268 LVEKFPVISVPHIPEKQATGRFEEDFISKRRRGLIWWMNHMTSHPVLARCDVFQHFLSC-SSTDE 331

Human   388 KAWKQGKRKAEKDEMVGANFFLTLSTPPAAALDLQEVESKIDGFKCFTKKMDDSALQLNHTANEF 452
            |||||||||||||||||||||||:|||| |.||||:|||:|||||.|:||||||.:|:|.|.:||
Zfish   332 KAWKQGKRKAEKDEMVGANFFLTISTPP-APLDLQDVESRIDGFKVFSKKMDDSVIQVNATLSEF 395

Human   453 ARKQVTGFKKEYQKVGQSFRGLSQAFELDQQAFSVGLNQAIAFTGDAYDAIGELFAEQPRQDLDP 517
            ||||:.|||||||||||||:.||||||:|||::|:|||||||:||:||:.||:.|.|||:||:||
Zfish   396 ARKQIAGFKKEYQKVGQSFKYLSQAFEMDQQSYSIGLNQAIAYTGEAYEVIGDYFVEQPKQDVDP 460

Human   518 VMDLLALYQGHLANFPDIIHVQKGKAWPLEQVIWSVLCRLKGATLTAVPLWVSESYSTGALTKVK 582
            ||||||||||||.|:||||||||                                   |||||||
Zfish   461 VMDLLALYQGHLTNYPDIIHVQK-----------------------------------GALTKVK 490

Human   583 ESRRHVEEGKMEVQKADGIQDRCNTISFATLAEIHHFHQIRVRDFKSQMQHFLQQQIIFFQKVTQ 647
            ||::||||||||.|.||||:||||.|||||:|||.:|||.|||||||||||||||||.||||||.
Zfish   491 ESQKHVEEGKMESQHADGIRDRCNIISFATMAEIQYFHQTRVRDFKSQMQHFLQQQISFFQKVTG 555

Human   648 KLEEALHKYDS 658
            ||||||.|||:
Zfish   556 KLEEALQKYDN 566

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SNX18	XP_047272635.1	SH3_SNX18	4..58	CDD:212830	42/53 (79%)
		PHA01929	<81..>138	CDD:177328	14/56 (25%)
		PX_SNX18	276..403	CDD:132819	114/126 (90%)
		BAR_SNX18	415..656	CDD:153354	161/240 (67%)
snx18a	NP_001093476.1	SH3	4..58	CDD:473055	42/53 (79%)
		PX_SNX18	221..347	CDD:132819	114/126 (90%)
		BAR_SNX18	358..564	CDD:153354	162/241 (67%)