Protein Alignment SNX18 and snx18

DIOPT Version :10

• Sequence 1: XP_047272635.1
• Gene: SNX18 / 112574
• HGNCID: 19245
• Length: 659
• Species: Homo sapiens
• Sequence 2: NP_001011173.1
• Gene: snx18 / 496591
• XenbaseID: XB-GENE-958823
• Length: 585
• Species: Xenopus tropicalis
• Alignment Length: 679
• Identity: 439/679 - (64%)
• Similarity: 498/679 - (73%)
• Gaps: 116/679 - (17%)

Human     1 MALRARALYDFRSENPGEISLREHEVLSLCSEQDIEGWLEGVNSRGDRGLFPASYVQVIRAPEPG 65
            ||||||||||||:|||||:||||.|||||||||||||||||:||||:|||||||||:|:|..
 Frog     1 MALRARALYDFRAENPGEVSLRESEVLSLCSEQDIEGWLEGLNSRGERGLFPASYVEVLRGE--- 62

Human    66 PAGDGGPGAPA----RYANVPPGGFEPLPVAPPASFKPPPDAFQALLQPQQAPPPSTFQPPGAGF 126
            |||...|..||    ||||:|.||:||   |.|         ||:...||.
 Frog    63 PAGPPPPPPPALGDSRYANLPSGGYEP---AQP---------FQSAAAPQL-------------- 101

Human   127 PYGGGALQP-SPQQLYGGYQASQGSDDDWDDEWDD-SSTVADEPGALGSGAYP----DLDGSSSA 185
               |.|.|| :|.   |||.|||.||||||||||| |||.||||.|...|:||    |.:|||
 Frog   102 ---GLAFQPRAPP---GGYPASQPSDDDWDDEWDDSSSTAADEPAAQPGGSYPGGYHDYEGSS-- 158

Human   186 GVGAAGRYRLSTRSDLSLGSRGGSVPPQHHPSGP----------KSSATVSRNLNRFSTFVKSGG 240
                  |||:|||||:              |.||          |.||||||||||||.||||||
 Frog   159 ------RYRVSTRSDM--------------PPGPSSLASSQAAGKGSATVSRNLNRFSAFVKSGG 203

Human   241 EAFVLGEASGFVKDGDKLCVVLGPYGPEWQENPYPFQCTIDDPTKQTKFKGMKSYISYKLVPTHT 305
            ||||||||:|||:||||||||.|..|||||||||||:|:||:||||||||||||||||:|:|:||
 Frog   204 EAFVLGEAAGFVRDGDKLCVVPGAEGPEWQENPYPFRCSIDEPTKQTKFKGMKSYISYRLLPSHT 268

Human   306 QVPVHRRYKHFDWLYARLAEKFPVISVPHLPEKQATGRFEEDFISKRRKGLIWWMNHMASHPVLA 370
            .:.|||||||||||||||.:||||:|||.:|||||||||||||||||:|||:|||.||.||||||
 Frog   269 GLQVHRRYKHFDWLYARLLDKFPVVSVPRIPEKQATGRFEEDFISKRKKGLVWWMEHMCSHPVLA 333

Human   371 QCDVFQHFLTCPSSTDEKAWKQGKRKAEKDEMVGANFFLTLSTPPAA-ALDLQEVESKIDGFKCF 434
            :||.|||||:|   ||||||||||||.|:|||||||||||||.||.: .|:..:|:.::||||.|
 Frog   334 RCDAFQHFLSC---TDEKAWKQGKRKCERDEMVGANFFLTLSLPPGSPVLEPHDVDGRLDGFKVF 395

Human   435 TKKMDDSALQLNHTANEFARKQVTGFKKEYQKVGQSFRGLSQAFELDQQAFSVGLNQAIAFTGDA 499
            ||:||:..|||:.||.||||||..|||||||||||:.|||.||||:|...||.|||:|:||||:|
 Frog   396 TKRMDEGVLQLSQTAGEFARKQAAGFKKEYQKVGQAVRGLGQAFEMDHMVFSAGLNRAMAFTGEA 460

Human   500 YDAIGELFAEQPRQDLDPVMDLLALYQGHLANFPDIIHVQKGKAWPLEQVIWSVLCRLKGATLTA 564
            |:||||:|||||||||||:|||||:|||||||||||||||:
 Frog   461 YEAIGEMFAEQPRQDLDPIMDLLAVYQGHLANFPDIIHVQR------------------------ 501

Human   565 VPLWVSESYSTGALTKVKESRRHVEEGKMEVQKADGIQDRCNTISFATLAEIHHFHQIRVRDFKS 629
                       ||||||:||::.|||||:|:|||..||:|||.||:||||||||||:||||||||
 Frog   502 -----------GALTKVRESKKQVEEGKLELQKAGEIQERCNVISYATLAEIHHFHKIRVRDFKS 555

Human   630 QMQHFLQQQIIFFQKVTQKLEEALHKYDS 658
            ||||||||||.||||||.||||||.|||:
 Frog   556 QMQHFLQQQICFFQKVTLKLEEALQKYDA 584

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SNX18	XP_047272635.1	SH3_SNX18	4..58	CDD:212830	48/53 (91%)
		PHA01929	<81..>138	CDD:177328	15/57 (26%)
		PX_SNX18	276..403	CDD:132819	100/126 (79%)
		BAR_SNX18	415..656	CDD:153354	153/241 (63%)
snx18	NP_001011173.1	SH3_SNX18	4..58	CDD:212830	48/53 (91%)
		PX_domain	239..363	CDD:470617	100/126 (79%)
		BAR	376..582	CDD:472257	152/240 (63%)