Protein Alignment SNX18 and Snx6

DIOPT Version :10

• Sequence 1: XP_047272635.1
• Gene: SNX18 / 112574
• HGNCID: 19245
• Length: 659
• Species: Homo sapiens
• Sequence 2: NP_001245939.1
• Gene: Snx6 / 34126
• FlyBaseID: FBgn0032005
• Length: 455
• Species: Drosophila melanogaster
• Alignment Length: 548
• Identity: 98/548 - (17%)
• Similarity: 178/548 - (32%)
• Gaps: 202/548 - (36%)

Human   175 AYPDLDGSSSAGVGAAGRYRLSTRSDLSLGSRGGSVPPQHHPSGPKSSATVSRNLNRFSTFVKSG 239
            |.|...|.:.|..||..            || |.:..|....|.|.:.|
  Fly    32 ATPPATGGAPAPSGATN------------GS-GSATSPDSSSSAPATPA---------------- 67

Human   240 GEAFVLGEASGFVKDGDKLCVVLGPYGPEWQENPYPFQCTIDDPTKQTKFKGMKSYISYKLVPTH 304
                ||||.:..|:..|.|                       ...::.||          .|.|.
  Fly    68 ----VLGENALHVEISDAL-----------------------SEKEKVKF----------TVHTR 95

Human   305 TQVP--------VHRRYKHFDWLYARLAEK-----FPVISVPHLPE------------------- 337
            |.:|        |.|:::.|.||:.|:.|.     :.:...|..|:
  Fly    96 TTLPGFSKKDNNVVRQHEEFVWLHDRIEENDDYAGYIIPPCPPRPDFDASREKLQRLGEGEGNMT 160

Human   338 ----KQATGRFEEDFISKRRKGLIW---WMNHMASHPVLAQCDVFQHFLTCPSSTDEKAWKQGKR 395
                |:.....|.::::..:|.:..   ::..:|||||..   |.||.........:...|..|:
  Fly   161 KEEFKKMKSELEAEYLATFKKTVAMHEVFLRRLASHPVFR---VDQHLKVFLEYDQDLCAKPRKK 222

Human   396 KAEKDEMVGANFFLTLSTP------PAAALDLQE-VESKIDGFKCFTKKMDDSALQLNHTANEFA 453
            .|     :...|..:|...      .|...|:.: .|:::.....:...:.::||:   |.....
  Fly   223 MA-----IFGGFVKSLGKTTDEILLSATVRDVNDFFENELQFLTEYHGHLREAALR---TEKMTQ 279

Human   454 RKQVTGFKKEYQKVGQSFRGLSQAFELDQQAFSVGLNQAIAFTGDAYDAIGELFAEQPR----QD 514
            |.:..|  ..:||:..:...||...:.:.:.|       :|.|.:.::.|..|   :.|    ||
  Fly   280 RHKDVG--DSHQKISNALTQLSTTEKGNVETF-------VAKTAEIFERIKNL---ETRVASDQD 332

Human   515 LDPVMDLLALYQGHLANFPDIIHVQKGKAWPLEQVIWSVLCRLKGATLTAVPLWVSESYSTGALT 579
            | .:.|.|..||.         .....||        .::.||:                  .|.
  Fly   333 L-KLGDTLRYYQR---------DSDAAKA--------LLIRRLR------------------CLA 361

Human   580 KVKESRRHVEEGK---------MEVQKADGIQ----DRCNTISFATLAEIHHFHQIRVRDFKS-- 629
            ..:.:.|::|:.:         :|||:|:..|    ::..::|.....|:..|...||..||.
  Fly   362 AYEAANRNLEKARSKNKDVHAPLEVQEAETAQAEACEKFESMSACGKEELIGFRNRRVAAFKKSL 426

Human   630 ------QMQH------FLQQQIIFFQKV 645
                  :::|      :|:|.::..:::
  Fly   427 VELSELEIKHAKTQYEYLRQSLLALKEI 454

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SNX18	XP_047272635.1	SH3_SNX18	4..58	CDD:212830
		PHA01929	<81..>138	CDD:177328
		PX_SNX18	276..403	CDD:132819	29/165 (18%)
		BAR_SNX18	415..656	CDD:153354	47/263 (18%)
Snx6	NP_001245939.1	PX_SNX5_like	72..212	CDD:132802	29/175 (17%)
		BAR_SNX5_6	228..452	CDD:153305	49/274 (18%)