Protein Alignment SNX18 and Snx1

DIOPT Version :10

• Sequence 1: XP_047272635.1
• Gene: SNX18 / 112574
• HGNCID: 19245
• Length: 659
• Species: Homo sapiens
• Sequence 2: NP_608777.1
• Gene: Snx1 / 33560
• FlyBaseID: FBgn0031534
• Length: 458
• Species: Drosophila melanogaster
• Alignment Length: 516
• Identity: 120/516 - (23%)
• Similarity: 180/516 - (34%)
• Gaps: 158/516 - (30%)

Human   200 DLSLGSRGGSVPPQHHPSGPKSSATVSRNLNRFSTFV-----KSGGEAFVLGEASGFVKDGDKLC 259
            |::.|:..||...:.....| .|.|:.|  |....||     .|.|:...|.|.  ...|||
  Fly    16 DINNGAATGSEDEEEEVPAP-GSVTLDR--NESDLFVSALSPSSIGDIHPLQEV--LTDDGD--- 72

Human   260 VVLGPYGPEWQENPYPFQCTIDDPTKQTKFKGMKSYISYKLVPTHTQVP--------VHRRYKHF 316
                          |.....:.||.|..  .||.||::|| |.|.|.:|        ..||:..|
  Fly    73 --------------YFISIVVSDPQKIG--DGMGSYLAYK-VTTKTNIPKFKRSEFSTLRRFSDF 120

Human   317 DWLYARLAEKFPVIS--VPHLPEKQATGR---------------FEEDFISKRRKGLIWWMNHMA 364
            ..::..|..|:..:.  :|..|.|...|.               ..::::..||..|..:::..|
  Fly   121 LGIHDLLVGKYMRLGRIIPPAPSKNIIGSTKVKISPQQSEPGTPMTQEWVEIRRAALERFVHRTA 185

Human   365 SHPVLAQCDVFQHFLTCPSSTDEKAWKQGKRKAEKDEMVGANFFLTLSTPPAAALDLQEVESKID 429
            .||||.....|.:||    .:|::.    .|......:.||......:       .:.|..:||
  Fly   186 QHPVLRVDLDFMNFL----ESDQEL----PRSVNTSALSGAGVIRLFN-------KVGETVNKI- 234

Human   430 GFKCFTKKMD----------------DSALQLNHTANE---FARKQ---VTGFKKEYQKVGQSFR 472
                 |.|||                |:.||..|.|.:   .:|::   :||.      |.:|..
  Fly   235 -----TYKMDENDPWFDDKITEVESLDANLQKLHNAMKSLVTSRRELSLLTGL------VAKSAA 288

Human   473 GLSQAFELDQQAFSVGLNQAIAFTGDAYDAIGELFAEQPRQDLDPVMDLLALYQGHLANFPDIIH 537
            .||...|      ..||::|::...|..:.|..|.:||...|...:.:.:..|.|.......|.|
  Fly   289 MLSTCEE------HTGLSRALSNLADVEEKIELLRSEQANSDFFILAEFIKDYLGLFGAIKCIFH 347

Human   538 VQKGKAWPLEQVIWSVLCRLKGATLTAVPLWVSESYSTGALTKVKESRRHVE---------EGKM 593
                     |:|             .|...|   .|:...|:|.:|:|...|         :.:.
  Fly   348 ---------ERV-------------KAFQNW---QYAQMQLSKRRENRGRFELANRADKLDQAQQ 387

Human   594 EVQKADGIQDRC----NTISFATLAEIHHFHQIRVRDFK--------SQMQHFLQQQIIFF 642
            ||.:..|...||    :.||.....|:..|...||:|||        .||.|  ||||:.:
  Fly   388 EVDEWQGKVQRCQQQFDDISAEIKREMERFELTRVKDFKVNIIKYIEDQMAH--QQQIVSY 446

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SNX18	XP_047272635.1	SH3_SNX18	4..58	CDD:212830
		PHA01929	<81..>138	CDD:177328
		PX_SNX18	276..403	CDD:132819	35/151 (23%)
		BAR_SNX18	415..656	CDD:153354	64/271 (24%)
Snx1	NP_608777.1	PX_SNX1_2_like	75..203	CDD:132769	33/134 (25%)
		BAR_SNX1_2	232..455	CDD:153307	63/260 (24%)