Protein Alignment SNX18 and pob1

DIOPT Version :10

• Sequence 1: XP_047272635.1
• Gene: SNX18 / 112574
• HGNCID: 19245
• Length: 659
• Species: Homo sapiens
• Sequence 2: NP_596828.1
• Gene: pob1 / 2539992
• PomBaseID: SPBC1289.04C
• Length: 871
• Species: Schizosaccharomyces pombe
• Alignment Length: 669
• Identity: 137/669 - (20%)
• Similarity: 220/669 - (32%)
• Gaps: 192/669 - (28%)

Human     7 ALYDFRSENPGEISLREHE--VLSLCSEQDIEGWLEGVNSRGDRGLFPASYVQVIRAPEPGPAGD 69
            ||:.|..::..|:.|.|..  :|....|:..:||.||.:.:|:||:||||:|::| :.|...:.|
pombe     9 ALHSFPGKSSDELPLVEGRKYLLIKMDEEFGDGWWEGEDEQGNRGIFPASHVELI-SDERSDSSD 72

Human    70 GGPG-----------------------------APARYANVPPGGFEPLPVAPPASFKPPPDAFQ 105
            ...|                             :...|:|      ..|..:..:....|.|
pombe    73 SRRGKEDFSISTAEVTRSSLSSSRSTSSRSDKDSEKLYSN------NSLSSSHSSILNGPLD--- 128

Human   106 ALLQPQQAPPPSTFQPPGAGFPYGGGALQPSPQQLYGGYQASQGSDDDWDDEWDDSSTVADEPGA 170
            :|.:|.   .||.|   .:.||   .:.|..|..|.....:|..|:.:..|        ||...|
pombe   129 SLSKPS---VPSNF---NSMFP---SSKQEGPSPLLDNQPSSDLSNFNTID--------ADYNNA 176

Human   171 LGSGAYPDLDGSSSAGVGAAGRYRLSTRSDLSLGSRGGSVPPQHHPSG----------PKSSATV 225
            ..|.:.|....|....:.|....| .|.:|:....:..|......|:.          |.||..|
pombe   177 SASTSAPATSASLKKVLSAEDSVR-ETITDIETALQNMSTSASRTPNDSSPLPYIENRPASSLAV 240

Human   226 S---RNLNRFST-----FVKSGGEAFVLGEASGFVKDGDKLCVVLGPYGPEWQENPYPFQCTIDD 282
            |   :|:..:||     ::.:.|                     ||...|.:.||....:..:
pombe   241 SEKIQNVPNWSTEEVVEWLMNAG---------------------LGSVAPNFAENEITGEILL-- 282

Human   283 PTKQTKFKGMKSYISYKLVPTH--TQVPVHRRYKHFDWLYAR-LAEKFPVISVP----------- 333
                    |:.|.:..:|..|.  .:..|.|:.:.....|.: |.|::|..:.|
pombe   283 --------GLDSNVLKELNITSFGKRFEVLRKIQQLKDSYEQSLYEEYPQFAEPISVSQSSDSSS 339

Human   334 HLPEK---QATGRFEEDFISKRRKGLIWWMNHMAS-HPVLAQCDVFQHFLTCPSSTDEKAWKQ-- 392
            .:|:|   :|.|...:.  |..|.|...::|...| .|.|:...|.....:.| |||   |.|
pombe   340 SIPKKSNDEAGGSPSKS--SPTRPGFNDYVNRPTSVMPSLSNMIVSPDLDSSP-STD---WNQYV 398

Human   393 --------GKRKAEKDEMVGANFFLTLSTPPAAALDLQEVESKIDGFKCFTKKMDDSAL--QLNH 447
                    .:........|..|.....|..|:|...:.:..|..|...      .:|.|  :|..
pombe   399 IPPLATPSSRNSKSTQSAVPENVSRFDSNEPSATSPILKRSSPTDSIS------QNSGLPSRLTE 457

Human   448 TANEFARKQVTGFKKEYQKVGQSFRGLSQAFELDQQAFSVGLNQAIAFTGDAYDAIGELFAEQPR 512
            ..:..:...:     :..|.|.||.||..                       :.:.|.|:|.||.
pombe   458 PISSPSTSSI-----DVDKEGTSFPGLPY-----------------------HSSKGNLYAPQPS 494

Human   513 QDLDPVMDLLALYQGHLANFPDIIHVQKGKAWPLEQVIWSVLCRLKGATLTAV----PLWVS--- 570
            .::.......|.....:...| |....|||| |...:....|..|....:|.:    |..:|
pombe   495 SNVPTKFTGGASESSSVPPRP-IPSAMKGKA-PASAISIEALEELDPPKITTIDGESPSSISSRL 557

Human   571 -----ESYSTGALTKVKES 584
                 |..|:.::||..||
pombe   558 PSSNLEQGSSSSVTKSPES 576

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SNX18	XP_047272635.1	SH3_SNX18	4..58	CDD:212830	20/52 (38%)
		PHA01929	<81..>138	CDD:177328	11/56 (20%)
		PX_SNX18	276..403	CDD:132819	29/154 (19%)
		BAR_SNX18	415..656	CDD:153354	37/184 (20%)
pob1	NP_596828.1	SH3	5..61	CDD:214620	19/51 (37%)
		SAM_BOI-like_fungal	248..311	CDD:188934	14/93 (15%)
		Herpes_BLLF1	<352..686	CDD:282904	54/267 (20%)
		PH_Boi	700..807	CDD:270126