Protein Alignment SNX18 and lst-4

DIOPT Version :10

• Sequence 1: XP_047272635.1
• Gene: SNX18 / 112574
• HGNCID: 19245
• Length: 659
• Species: Homo sapiens
• Sequence 2: NP_001379029.1
• Gene: lst-4 / 178361
• WormBaseID: WBGene00003086
• Length: 592
• Species: Caenorhabditis elegans
• Alignment Length: 582
• Identity: 190/582 - (32%)
• Similarity: 297/582 - (51%)
• Gaps: 89/582 - (15%)

Human    95 ASFKPPPDAFQALLQPQQAPPPSTFQPPGAG---FPYGGGALQPSPQQLYGGYQASQ-------- 148
            :|||......:::|.|..  ||::..||.|.   |...|||.:.:....||.....|
 Worm    81 SSFKKSGAISKSVLPPPL--PPTSSGPPAASSRPFDDWGGASEVAAPPSYGAQHHHQPTPSVPEV 143

Human   149 ------GSDDDWDDEWDDSSTVADEPGALGSGAYPDLDGSSSAGVGAAGRYRLSTRSDLSLGSRG 207
                  ..:||:||||.|... ..||      ..|::..|    :|:      ::|.||   ||.
 Worm   144 TRSSYPSQNDDFDDEWTDEDD-EQEP------TRPNVQSS----IGS------NSRRDL---SRS 188

Human   208 GSVPPQHHPSGPKSSATVSRNLNRFSTFVKSGGEAFVLGEASGFVKDGDKLCVVLGPYGPEWQEN 272
            .|    .|....:.|..|::|:||||.|||||.||:|:||:....:..::..||:.....:|:..
 Worm   189 HS----EHGGPDRGSNKVNKNINRFSNFVKSGVEAYVIGESKTTSQISERHEVVMNNGIIQWKPI 249

Human   273 PYPFQCTIDDPTKQTKFKGMKSYISYKLVP--THTQVPVHRRYKHFDWLYARLAEKFPVISVPHL 335
            ...:.|.:|.|.|::|.||:||:|:|.:..  |:.|..|.|||||||||:.:|:.|:.:|.:|.|
 Worm   250 QQYYTCIVDKPKKESKLKGLKSFIAYSITSSLTNIQRQVSRRYKHFDWLHEQLSAKYVLIPIPPL 314

Human   336 PEKQATGRFEEDFISKRRKGLIWWMNHMASHPVLAQCDVFQHFLTCPSSTDEKAWKQGKRKAEKD 400
            ||||..||:|||.|..|:..|..|:|.:..||||:|.:|:.||::|   ||||.||.|||:||||
 Worm   315 PEKQVAGRYEEDLIDHRKHILQLWVNKICRHPVLSQSEVWLHFISC---TDEKDWKNGKRRAEKD 376

Human   401 EMVGANFFLTLSTPPAAALDLQEVESKIDGFKCFTKKMDDSALQLNHTANEFARKQVTGFKKEYQ 465
            |.:| ..||...|.|...||...|:.:::.|:...|..:::...:....|.|.:......|:.:|
 Worm   377 EYIG-GAFLNCITVPHQPLDPNNVDMQVERFQRSVKTSEEAMRVMQERMNMFQKVFAGPVKQNWQ 440

Human   466 KVGQSFRGLSQAFELDQQAFSVGLNQAIAFTGDAYDAIGELFAEQPRQDLDPVMDLLALYQGHLA 530
            |:|.:|:.|.|:||:|:...|..|.:|:|:|...|..||::|....:.|::||::.|..|:|.:.
 Worm   441 KMGSAFKTLQQSFEIDETVASRRLTEALAYTASEYHEIGQVFDAHTKNDMEPVLENLYSYKGTVQ 505

Human   531 NFPDIIHVQKGKAWPLEQVIWSVLCRLKGATLTAVPLWVSESYSTGALTKVKESRRHVEEGKMEV 595
            |.||||.|.|                                   .|:.|.::|     ||::..
 Worm   506 NVPDIIQVHK-----------------------------------QAVQKFRDS-----EGRLSS 530

Human   596 QKADGIQDRCNTISFATLAEIHHFHQIRVRDFKSQMQHFLQQQIIFFQKVTQKLEEALHKYD 657
            .:|:.::.|.:.:|:..:||:.|....:|.|.||.|..:|::|.:|:|:|..||.....:||
 Worm   531 AEAEKMKQRIDAMSYTVIAEVQHQTAEKVEDMKSTMGTYLKKQAMFYQEVATKLTSLAARYD 592

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SNX18	XP_047272635.1	SH3_SNX18	4..58	CDD:212830
		PHA01929	<81..>138	CDD:177328	14/45 (31%)
		PX_SNX18	276..403	CDD:132819	65/128 (51%)
		BAR_SNX18	415..656	CDD:153354	63/240 (26%)
lst-4	NP_001379029.1	PX_SNX9_18_like	253..379	CDD:132772	65/128 (51%)
		BAR	362..592	CDD:472257	80/270 (30%)