DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HRH3 and hrh3

DIOPT Version :9

Sequence 1:	XP_005260323.1	Gene:	HRH3 / 11255	HGNCID:	5184	Length:	453	Species:	Homo sapiens
Sequence 2:	NP_001020689.1	Gene:	hrh3 / 561773	ZFINID:	ZDB-GENE-040724-204	Length:	473	Species:	Danio rerio

Alignment Length:	443	Identity:	240/443 - (54%)
Similarity:	291/443 - (65%)	Gaps:	66/443 - (14%)

- Green bases have known domain annotations that are detailed below.

Human    29 FSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVP 93
            ||.:.:..|..||.||:.|||||||||:||||.:.|||||.|||.|||||:|||||.||||:|:|
Zfish    59 FSPSTSIFLTVLMTLLVFATVLGNALVILAFVVEKSLRTQGNFFFLNLAIADFLVGGFCIPVYIP 123

Human    94 YVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLL 158
            |||||.|..|||||||||||||:|||:|.|||||||:|||.|||:|||||.|:|.|:.||.|||.
Zfish   124 YVLTGEWRLGRGLCKLWLVVDYMLCTASVFNIVLISFDRFQSVTKAVSYRCQKGITKDAVLKMLC 188

Human   159 VWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYL 223
            ||:.|||||||||:|||:::|||.:|:|.|||||::|||||:||||:||||||:|||:||||||:
Zfish   189 VWLAAFLLYGPAIISWEHITGGSVVPDGECYAEFYFNWYFLMTASTVEFFTPFISVTYFNLSIYI 253

Human   224 NIQRRTRLRLDGAREAAGPEPPPEAQPS---------PPPPPGCWGCWQKGHGEAM------PLH 273
            ||:.|..:|              |.||:         .|          .|.|:..      |:.
Zfish   254 NIRNRCAMR--------------EEQPTYVRLRSFKMKP----------LGAGDVQRVFFVRPVE 294

Human   274 RYGVGEAAVGAEAGEATLGGGGGGGSVASPTSSSGSSSRGTERPRSLKRGSKP--------SASS 330
            ...|.:.|..:.....        .|.|..:::...:.|.::|..|......|        :||.
Zfish   295 ESRVADLASRSRCCRL--------ASTAKVSAAEFGNGRQSKRRDSTLADLPPLQVEERILAASE 351

Human   331 ASL----------EKRMKMVSQSFTQRFRLSRDRKVAKSLAVIVSIFGLCWAPYTLLMIIRAACH 385
            |..          ..|..||: |...|||||||:||||||||||.:|||||||||||||||||||
Zfish   352 AQFHYVDHSAGPHRHRPDMVA-SLANRFRLSRDKKVAKSLAVIVCVFGLCWAPYTLLMIIRAACH 415

Human   386 GHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLLCPQKLKIQPHS 438
            |.||..|.||.||||||.||::||:||||||.||:|||:|||||.|.||||.:
Zfish   416 GQCVQHYLYEISFWLLWINSSINPILYPLCHSSFKRAFSKLLCPSKTKIQPQN 468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HRH3	XP_005260323.1	7tm_1	51..412	CDD:278431	208/393 (53%)
hrh3	NP_001020689.1	7tm_1	81..442	CDD:278431	208/393 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	419	1.000	Domainoid score	I4177
eggNOG	1	0.900	-	-		E33208_3BA0J
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	479	1.000	Inparanoid score	I6791
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG43860
OrthoDB	1	1.010	-	-		D210951at7742
OrthoFinder	1	1.000	-	-		FOG0008030
OrthoInspector	1	1.000	-	-		otm28350
orthoMCL	1	0.900	-	-		OOG6_108667
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8330
SonicParanoid	1	1.000	-	-		X6932
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	14	14.270