Protein Alignment HRH3 and gar-1

DIOPT Version :9

• Sequence 1: XP_005260323.1
• Gene: HRH3 / 11255
• HGNCID: 5184
• Length: 453
• Species: Homo sapiens
• Sequence 2: NP_001024402.1
• Gene: gar-1 / 180922
• WormBaseID: WBGene00001517
• Length: 713
• Species: Caenorhabditis elegans
• Alignment Length: 690
• Identity: 130/690 - (18%)
• Similarity: 211/690 - (30%)
• Gaps: 310/690 - (44%)

Human    36 VLAALMALLIVATVLGNALVMLAFVADSSLRTQ-NNFFLLNLAISDFLVGAFCIPLYVPYVLTG- 98
            |:..::.:|.:.|::|||:|::|:..:.::..| :|.::::|||||.::|....|.:..|||.|
 Worm    26 VVWIIIIVLSLETIIGNAMVVMAYRIERNISKQVSNRYIVSLAISDLIIGIEGFPFFTVYVLNGD 90

Human    99 RWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLV--WV 161
            ||..|...|:.||.:||.||..|...::||:.||:|||.....|...|..|:   .::|:|  |:
 Worm    91 RWPLGWVACQTWLFLDYTLCLVSILTVLLITADRYLSVCHTAKYLKWQSPTK---TQLLIVMSWL 152

Human   162 LAFLLYGPAILSWEYLSGGSSIPEG-HCYAEFFYNWYFLITASTLEFFTPFLSV----------- 214
            |..:::|..|..|:.::|.|:...| .|.|.|..|.|..:......::|..:::
 Worm   153 LPAIIFGIMIYGWQAMTGQSTSMSGAECSAPFLSNPYVNMGMYVAYYWTTLVAMLILYKGIHQAA 217

Human   215 ------------------------TFFNLSIYL---------------------------NIQR- 227
                                    |...:|:.|                           |::|
 Worm   218 KNLEKKAKAKERRHIALILSQRLGTQVGVSLMLQSKAEKEKAEEAQKDSGYTSNQAGDANNLRRF 282

Human   228 ----------------RTRLRLDGA-------------REAAG------------PEPPPEAQ-- 249
                            ...|.::|:             .|.:|            |.|.|.|.
 Worm   283 GFSEPETSQFRVDPNSNNNLNVEGSLNTENDQNLGVIEEERSGFLSRRESNESYYPGPHPTAANS 347

Human   250 ------------------PSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGE-------- 288
                              ||..|        .|.:|......||...|:.......:
 Worm   348 RRCSEMEKVSLLSESDGVPSTRP--------AKSYGRLSLRSRYSASESITTTHENDEKEVEKAD 404

Human   289 --ATLGGGGGGGSVAS---------------------------------PTSS------------ 306
              ..|......|||.:                                 |.||
 Worm   405 SLQKLFADDELGSVLNFKEEKLKNTDSNNDSDTTSVILQRSRKYKKNKRPRSSRRSEHSTPRQIA 469

Human   307 --------------------------------------------------------SGSSS---- 311
                                                                    .||||
 Worm   470 KVKQAEGTAAQLIEESVPDDDQTETIEVKRTDRWVVSMKKRIARALIRRRSTTRPERGSSSNSDD 534

Human   312 -----RGTERPRSLKRG-----------------SKP---------------SASSASLE----- 334
                 .|.|:|.....|                 |:|               |||..|.:
 Worm   535 SSSEVEGEEKPEVRNNGLKIPQLTVNNENRGETSSQPGRDRLAPPNKTDTFLSASGVSRKISTIS 599

Human   335 ---KRMKMVSQSFTQRFRLSRDRKVAK----------SLAVIVSIFGLCWAPYTLLMIIRAACHG 386
               .|.|::|..|......:|.||..|          ::..||..|.:.|:||.::..:...|.|
 Worm   600 TVITREKVISSIFAPIAVFNRGRKQTKAEKRAHKAFRTITFIVGFFAILWSPYYIMATVYGFCKG 664

Human   387 HCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKL 426
            .|:|.:.|..|:::.:.||:.||..|.|.:..||.||.::
 Worm   665 ECIPSFLYTLSYYMCYLNSSGNPFAYALANRQFRSAFMRM 704

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HRH3	XP_005260323.1	7tm_1	51..412	CDD:278431	121/659 (18%)
gar-1	NP_001024402.1	7tm_4	39..>163	CDD:304433	44/126 (35%)
		7tm_1	41..>236	CDD:278431	55/197 (28%)
		7tm_4	<586..705	CDD:304433	34/119 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910