DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC6A14 and List

DIOPT Version :9

Sequence 1:	NP_009162.1	Gene:	SLC6A14 / 11254	HGNCID:	11047	Length:	642	Species:	Homo sapiens
Sequence 2:	NP_611364.2	Gene:	List / 37157	FlyBaseID:	FBgn0034381	Length:	564	Species:	Drosophila melanogaster

Alignment Length:	582	Identity:	210/582 - (36%)
Similarity:	312/582 - (53%)	Gaps:	59/582 - (10%)

- Green bases have known domain annotations that are detailed below.

Human    39 WSKKSDYLLSMIGYAVGLGNVWRFPYLTYSNGGGAFLIPYAIMLALAGLPLFFLECSLGQFASLG 103
            |....::|.|.|..:|||||:|||||:.:.||||.|:|||.|.|.:.|.|:::||.|||||...|
  Fly    21 WGNGLEFLFSCISLSVGLGNIWRFPYIAFQNGGGTFVIPYLIALLVIGRPVYYLEISLGQFTGRG 85

Human   104 PVSVWRILPLFQGVGITMVLISIFVTIYYNVIIAYSLYYMFASFQSELPWKNCSSWSDKNCSRSP 168
            .|..:.:.||.:||.:..||.:.....||:.|:|.:|.:..|||.|||||..|  |
  Fly    86 VVKAFDMAPLLKGVALGQVLATAASITYYSSIMALTLRFWLASFGSELPWSRC--W--------- 139

Human   169 IVTHCNVSTVNKGIQEIIQMNKSWVDINNFTCINGSEIYQPGQL-PSEQYWNKVALQRSSGM-NE 231
                                 :||    ...|.:|:.....|:: |::.|:.:..|.....: |.
  Fly   140 ---------------------ESW----GTDCHDGNAQNSSGKMSPAQLYFEREILHEVPNIDNG 179

Human   232 TGVIVWYLALCLLLAWLIVGAALFKGIKSSGKVVYFTALFPYVVLLILLVRGATLEGASKGISYY 296
            ..:..|.|..||.:|||::|..|.:|||||||..||..:||||||||||:|..||.||..||.|:
  Fly   180 LSLPNWQLVACLAIAWLVIGGVLIRGIKSSGKAAYFLGVFPYVVLLILLLRAVTLPGAIDGIIYF 244

Human   297 IGAQSNFTKLKEAEVWKDAATQIFYSLSVAWGGLVALSSYNKFKNNCFSDAIVVCLTNCLTSVFA 361
            ...|  :.:|....||..|.||:|:||::.:|.|:..:|||.|..|.::|.:::...:..:|:.|
  Fly   245 FKPQ--WRELLNPLVWYAAVTQVFFSLAICFGTLITYASYNNFNRNVYNDIVIITTMDSCSSIIA 307

Human   362 GFAIFSILGHMAHISGK-EVSQVVKSGFDLAFIAYPEALAQLPGGP-FWSILFFFMLLTLGLDSQ 424
            |...|.|||::|..:|. ::..|||.|..||||:||||:|:....| .:::|||.||..||:.|.
  Fly   308 GCITFGILGNLARETGNPDIGSVVKGGAGLAFISYPEAIAKFEYVPQMFAVLFFLMLFVLGIGST 372

Human   425 FASIETITTTIQDLF----PKVMKKMRVPITLGCCLVLFLLGLVCVTQAGIYWVHLIDHFCAGWG 485
            ......|...|:|.|    |.:.|     :..|..::.|.:.:|.:|..|.:.::|:|.:...:.
  Fly   373 VGMGSCILRVIRDQFGLRSPPIWK-----LASGLTVLGFSVSIVYMTPGGQFILNLVDFYGVSFT 432

Human   486 ILIAAILELVGIIWIYGGNRFIEDTEMMIGAKR-WIFWLWWRACWFVITPILLIAIFIWSLVQFH 549
            .||.||.|||.:.||||.|||.||.:.|:|.:. |    :||.||..|||.|:.|:.|:.|:...
  Fly   433 ALILAIGELVAVAWIYGVNRFCEDIKFMMGIETGW----YWRLCWRFITPGLMTAVLIYMLLDMS 493

Human   550 RPNYGAIPYPDWGVALGWCMIVFCIIWIPIMAIIKIIQAK---GNIFQRLISCCRPASNWGP 608
            ...|..:.||......|..:....:|.:|..||..|.:.:   |:.:||:.:.|:|:..|||
  Fly   494 ALEYKGVGYPTLAHVFGCFLATLGLIQLPGWAIYAIYKKRGHNGSFWQRIRAACKPSDTWGP 555

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC6A14	NP_009162.1	SLC6sbd_ATB0	36..641	CDD:271391	210/582 (36%)
SLC6A14	NP_009162.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	622..642
List	NP_611364.2	SLC6sbd	19..489	CDD:271359	192/514 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11616
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920