Protein Alignment SLC6A14 and CG8850

DIOPT Version :10

• Sequence 1: NP_009162.1
• Gene: SLC6A14 / 11254
• HGNCID: 11047
• Length: 642
• Species: Homo sapiens
• Sequence 2: NP_725122.2
• Gene: CG8850 / 36331
• FlyBaseID: FBgn0033708
• Length: 629
• Species: Drosophila melanogaster
• Alignment Length: 625
• Identity: 219/625 - (35%)
• Similarity: 343/625 - (54%)
• Gaps: 50/625 - (8%)

Human    14 EKEKVSASSENFHVGENDENQDRGNWSKKSDYLLSMIGYAVGLGNVWRFPYLTYSNGGGAFLIPY 78
            |.|:::.:.|    .|::.:..|..||:..::|.|.|..:||||||||||::...||||||||||
  Fly    39 EGEELTINCE----AESESSGQRDQWSRGVEFLFSCIALSVGLGNVWRFPFIALENGGGAFLIPY 99

Human    79 AIMLALAGLPLFFLECSLGQFASLGPVSVWRILPLFQGVGITMVLISIFVTIYYNVIIAYSLYYM 143
            .|:|.|.|.|:::||..:|||:|.|.:..:.:.|:.:|:....|..:...|.||..|:|.::.|:
  Fly   100 VIVLLLIGRPVYYLEVIIGQFSSRGCIRAFDMAPIMRGIAYGQVYSTALATTYYACIMALTIRYL 164

Human   144 FASFQSELPWKNCSSWSDKNCSRSPIVTHCNVSTVNKGIQEIIQMNKSWVDINNFTCINGSEIYQ 208
            .|||...|||                 |:|           :::..||.| ....|..|.|.|.|
  Fly   165 VASFSEVLPW-----------------TYC-----------LVEWGKSCV-ATGATAANDSSIVQ 200

Human   209 PGQLPSEQYWNKVALQRSSGMNETGVIV--WYLALCLLLAWLIVGAALFKGIKSSGKVVYFTALF 271
             |...:|.::.:..|:....:::.|:..  |.|.||||..|:|:|..|.|||:||||..||.|||
  Fly   201 -GVSSAELFFTQTVLREPESLDDNGLGTPSWDLVLCLLATWVIIGTILSKGIRSSGKASYFLALF 264

Human   272 PYVVLLILLVRGATLEGASKGISYYIGAQSNFTKLKEAEVWKDAATQIFYSLSVAWGGLVALSSY 336
            |||::::||:|..||.||.:||.|::..|  :::|....||..|.||:|:||::.:|.||..:|:
  Fly   265 PYVIMIVLLIRAVTLPGAWQGIVYFLKPQ--WSQLLNPHVWYAAITQMFFSLAICFGTLVMYASF 327

Human   337 NKFKNNCFSDAIVVCLTNCLTSVFAGFAIFSILGHMA-HISGKEVSQVVKSGFDLAFIAYPEALA 400
            |.|..|...|.|::...:.|||:.||..||.|||::| ..:.|::|||||.|..||||:||||:|
  Fly   328 NDFNKNVHKDVIIITTIDSLTSILAGCIIFGILGNLAFETNTKDISQVVKGGAGLAFISYPEAIA 392

Human   401 QLPGGP-FWSILFFFMLLTLGLDSQFASIETITTTIQDLFPKVMKKMRVPITLGCCLVLFLLGLV 464
            :....| .:::|||||||.||:.|.......:...::|.|..:...:   :.:...::.||.|||
  Fly   393 KFKYLPQLFAVLFFFMLLVLGIGSNIGMASAVVNVVKDRFTHLPHWL---LAVSASIIGFLCGLV 454

Human   465 CVTQAGIYWVHLIDHFCAGWGILIAAILELVGIIWIYGGNRFIEDTEMMIGAKRWIFWLWWRACW 529
            .:|..|.:.::|:|.:...:..|:.||.||:.:.||||..|...|.|.|:..|...:   ||.||
  Fly   455 YMTPGGQFVLNLVDFYGCTFIALVLAIAELLAVGWIYGVKRICSDIEFMLNVKTSFY---WRICW 516

Human   530 FVITPILLIAIFIWSLVQFHRPNYGAIPYPDWGVALGWCMIVFCIIWIPIMAIIKIIQAKGNIF- 593
            .::.|.|:..:.::.|..:....|..:.||......||.:....::.:|..|::.|.|..|..|
  Fly   517 AIVAPGLMFLVLVYMLFSYEPLTYRGVQYPPVYYMAGWIIWGLGVLQLPFWALVTIYQQPGKTFG 581

Human   594 QRLISCCRPASNWGPYLEQHRGERYKDMVDPKKEADHEIP 633
            .:.....:|.:|||| |:..:.|.|  ::..|:|||.:.|
  Fly   582 SKFGLAMQPTANWGP-LQTQKFEAY--IIHRKREADFKSP 618

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC6A14	NP_009162.1	SLC6sbd_ATB0	36..641	CDD:271391	215/603 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	622..642		5/12 (42%)
CG8850	NP_725122.2	SLC6sbd	58..532	CDD:271359	189/511 (37%)