Protein Alignment SLC6A14 and ine

DIOPT Version :9

• Sequence 1: NP_009162.1
• Gene: SLC6A14 / 11254
• HGNCID: 11047
• Length: 642
• Species: Homo sapiens
• Sequence 2: NP_001162871.1
• Gene: ine / 33659
• FlyBaseID: FBgn0011603
• Length: 943
• Species: Drosophila melanogaster
• Alignment Length: 631
• Identity: 229/631 - (36%)
• Similarity: 366/631 - (58%)
• Gaps: 66/631 - (10%)

Human    18 VSASSENFHVGENDENQD----RGNWSKKSDYLLSMIGYAVGLGNVWRFPYLTYSNGGGAFLIPY 78
            :....::.::..:||...    :.:|:.|..::|:.|||:|||||||||||:.|.:|||.||:||
  Fly   315 LGVDDDDSYLDMSDETAQLKPRQQHWANKMQFVLACIGYSVGLGNVWRFPYMCYKSGGGVFLVPY 379

Human    79 AIMLALAGLPLFFLECSLGQFASLGPV-SVWRILPLFQGVGITMVLISIFVTIYYNVIIAYSLYY 142
            .|:|.:..:||.|:|.|:||:...||: ::.::.|||:|.|:..|::|..::.||:|||.||:||
  Fly   380 CIILFICSIPLLFMELSVGQYTGRGPIGALGQLCPLFKGAGLASVVVSFLMSTYYSVIIGYSIYY 444

Human   143 MFASFQSELPWKNCSS-WSDKNC---SRSPIVTHCNVSTVNKGIQEIIQMNKSWVDINNFTCING 203
            .|.||::|:||.:|:: |:..:|   .|             |||      |.|..|.:
  Fly   445 FFTSFKTEMPWIDCNNRWNTPDCWVPQR-------------KGI------NASAPDTS------- 483

Human   204 SEIYQPGQLPSEQYWNKVALQRSSGMNETGVIVWYLALCLLLAWLIVGAALFKGIKSSGKVVYFT 268
                   :.|||:::....||.|.|:...|::.|.|..||:.|||:|..|.:|.||||.||.|||
  Fly   484 -------RTPSEEFFENKVLQISGGLEYPGMMRWELFACLICAWLMVYFATWKSIKSSAKVRYFT 541

Human   269 ALFPYVVLLILLVRGATLEGASKGISYYIGAQSNFTKLKEAEVWKDAATQIFYSLSVAWGGLVAL 333
            |.||:|:::||:||..||:||::|:.::.  :..:::||.|.||.:||:|.|.||.:.:|.:::.
  Fly   542 ATFPFVLIIILMVRAVTLDGAAEGLRFFF--RPKWSELKNANVWINAASQNFNSLGITFGSMISF 604

Human   334 SSYNKFKNNCFSDAIVVCLTNCLTSVFAGFAIFSILGHMAHISGKEVSQVVKSGFDLAFIAYPEA 398
            :||||:.||...|.:.|...|.:||:..|...||.||::|......|..|:..|..:.|:.||:|
  Fly   605 ASYNKYNNNILRDTVAVSAVNMITSLLVGIFAFSTLGNLALEQNTNVRDVIGDGPGMIFVVYPQA 669

Human   399 LAQLPGGPFWSILFFFMLLTLGLDSQFASIETITTTIQDLFPKVMKK---MRVPITLGCCLVLFL 460
            :|::|....|:::||||||.|||:||||.:|.:.|:|||.||:.:|:   ....:.|..|::..|
  Fly   670 MAKMPYAQLWAVMFFFMLLCLGLNSQFAIVEVVVTSIQDGFPRWIKRHLGYHEIVVLFVCVISCL 734

Human   461 LGLVCVTQAGIYWVHLIDHFCAGWGILIAAILELVGIIWIYGGNRFIEDTEMMIGAKRWIFWLWW 525
            .|:..:.|.|||:..|:||:.|...|:..|..:::.|.|.||..|..::.:.|.| |...|:|
  Fly   735 FGMPNIIQGGIYYFQLMDHYAASVTIMFLAFCQMIAIAWFYGTGRLSKNVKQMTG-KAPSFYL-- 796

Human   526 RACWFVITPILLIAIFIWSLVQFHRPNY--GAIPYPDWGVALGWCMIVFCIIWIPIMAIIKIIQA 588
            |:||.|:.|.||.||::.||:.:|.|.|  |...||||...:||....|.:|.||..|:|..:::
  Fly   797 RSCWLVLGPCLLFAIWVLSLINYHEPTYHNGRYTYPDWAYGIGWMFASFSLICIPGYAVINFLRS 861

Human   589 KGNIF-QRLISCCRPASNWGPYLEQHRGERYKDMVDPKKEADHEIP 633
            .|:.| :|:.:..||             ..|:..:..:...:|:.|
  Fly   862 SGDTFWERIRNTLRP-------------NIYECKICGEHHCEHDYP 894

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC6A14	NP_009162.1	SLC6sbd_ATB0	36..641	CDD:271391	227/609 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	622..642		2/12 (17%)
ine	NP_001162871.1	SLC5-6-like_sbd	337..876	CDD:294310	222/576 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820