DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GPR45 and gpr45

DIOPT Version :9

Sequence 1:	NP_009158.3	Gene:	GPR45 / 11250	HGNCID:	4503	Length:	372	Species:	Homo sapiens
Sequence 2:	XP_005167494.1	Gene:	gpr45 / 795372	ZFINID:	ZDB-GENE-070912-629	Length:	375	Species:	Danio rerio

Alignment Length:	374	Identity:	235/374 - (62%)
Similarity:	292/374 - (78%)	Gaps:	4/374 - (1%)

- Green bases have known domain annotations that are detailed below.

Human     2 ACNSTSLEAYTYLLLNTSNASDSGSTQLPAPLRISLAIVMLLMTVVGFLGNTVVCIIVYQRPAMR 66
            |||.:||||...|....:...::.:..:|..||::||.:|:.|..:|||||.:||:||||:||||
Zfish     3 ACNGSSLEACGLLEPTETEMQEADTALMPTTLRVALAAIMIFMITIGFLGNGIVCLIVYQKPAMR 67

Human    67 SAINLLLATLAFSDIMLSLCCMPFTAVTLITVRWHFGDHFCRLSATLYWFFVLEGVAILLIISVD 131
            |||||||||||||||||||.|||||||||.|..|.||..|||:|..|||.||||||:||||||||
Zfish    68 SAINLLLATLAFSDIMLSLLCMPFTAVTLATTDWSFGMGFCRVSVMLYWLFVLEGVSILLIISVD 132

Human   132 RFLIIVQRQDKLNPRRAKVIIAVSWVLSFCIAGPSLTGWTLVEVPARAPQCVLGYTELPADRAYV 196
            ||||||||||||.|.|||::|..||.||.|::.|||.||....:.|:.|||:|||:|..|||.|.
Zfish   133 RFLIIVQRQDKLTPHRAKILIGASWALSLCVSLPSLVGWRTAGIGAQVPQCILGYSESLADRGYT 197

Human   197 VTLVVAVFFAPFGVMLCAYMCILNTVRKNAVRVHNQSD--SLDLRQLTRAGLRRLQRQQQVSVDL 259
            |.|.|||||.||||||.:|:|||||||:||:|:||.:.  |:.:..:::.||..||| .||::|:
Zfish   198 VLLAVAVFFVPFGVMLYSYLCILNTVRRNALRIHNHTSEGSVAISHVSKLGLTGLQR-PQVNIDM 261

Human   260 SFKTKAFTTILILFVGFSLCWLPHSVYSLLSVFSQRFYCGSSFYATSTCVLWLSYLKSVFNPIVY 324
            ||||:|||||||||:|||:|||||:|.|||||||:|||...:||..|...|||||||:||||::|
Zfish   262 SFKTRAFTTILILFIGFSVCWLPHTVVSLLSVFSRRFYLSPAFYPVSIGALWLSYLKAVFNPVIY 326

Human   325 CWRIKKFREACIELLPQTFQILPKVPERIRRRIQPSTVYVC-NENQSAV 372
            ||||:||||||:|.:|:||.:.||:|.|.||||:||.:||| :|.||:|
Zfish   327 CWRIRKFREACLEFMPKTFHLCPKIPGRSRRRIRPSNIYVCSSETQSSV 375

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GPR45	NP_009158.3	7tmA_GPR45	35..335	CDD:320525	201/301 (67%)
		TM helix 1	36..62	CDD:320525	14/25 (56%)
		TM helix 2	69..92	CDD:320525	21/22 (95%)
		TM helix 3	107..137	CDD:320525	24/29 (83%)
		TM helix 4	146..168	CDD:320525	11/21 (52%)
		TM helix 5	192..221	CDD:320525	20/28 (71%)
		TM helix 6	260..290	CDD:320525	24/29 (83%)
		TM helix 7	303..328	CDD:320525	16/24 (67%)
gpr45	XP_005167494.1	7tm_4	43..>161	CDD:304433	89/117 (76%)
gpr45	XP_005167494.1	7tm_1	52..326	CDD:278431	185/274 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194334022
Domainoid	1	1.000	382	1.000	Domainoid score	I5069
eggNOG	1	0.900	-	-		E33208_3BEH2
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5228
Inparanoid	1	1.050	485	1.000	Inparanoid score	I6691
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG51083
OrthoDB	1	1.010	-	-		D244591at7742
OrthoFinder	1	1.000	-	-		FOG0011960
OrthoInspector	1	1.000	-	-		oto43848
orthoMCL	1	0.900	-	-		OOG6_117130
Panther	1	1.100	-	-	LDO	PTHR24245
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6796
SonicParanoid	1	1.000	-	-		X7403
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	1	1.500	-	-
	17	17.340