DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GPR45 and moody

DIOPT Version :9

Sequence 1:	NP_009158.3	Gene:	GPR45 / 11250	HGNCID:	4503	Length:	372	Species:	Homo sapiens
Sequence 2:	NP_001188534.1	Gene:	moody / 31168	FlyBaseID:	FBgn0025631	Length:	670	Species:	Drosophila melanogaster

Alignment Length:	384	Identity:	87/384 - (22%)
Similarity:	152/384 - (39%)	Gaps:	74/384 - (19%)

- Green bases have known domain annotations that are detailed below.

Human     7 SLE-AYTYLLLNTSNASDSGSTQLPAPLRISLAIVMLLMTVVGFLGNTVVCIIVYQRPAMRSAIN 70
            ||| .|..|...|:....:.:|.....|....|::..|:.:||..||.:..:.:.:.|.:|:...
  Fly     8 SLEDGYPPLEALTTMVPPADATGFSQSLLTFAAVMTFLIMIVGICGNLLTVVALLKCPKVRNVAA 72

Human    71 LLLATLAFSDIMLSLCCMPFTAVTLITVRWHFGDHFCRLSATLYWFFVLEGVAILLI--ISVDRF 133
            ..:.:|..:|::.....:||..:..:...|..|...|||...:.:..:  ||::|.|  |:::|:
  Fly    73 AFIISLCIADLLFCALVLPFQGLRFVQGTWRHGQVLCRLIPFIQYGNI--GVSLLCIAMITINRY 135

Human   134 LIIVQRQDKLNPRRAK-----VIIAVSWVLSFCIAGPSLTG-WTLVEVPARAPQCVLGYTELPAD 192
            ::|...  .|..|..|     |:||..|:.|:.:..|:|.| |......:|...|.:    :..|
  Fly   136 VMITHH--GLYARIYKRHWIAVMIAACWLFSYGMQLPTLLGEWGRFGYDSRLQTCSI----MTDD 194

Human   193 RAY--VVTLVVAVFFAPFGVMLCAYMCILNTVRKNAVRVH---NQSDSL--DLRQLTRAGLRRL- 249
            ..:  ..||.:..|..|..|::..|..|...|.|:..|:.   .:.:|:  :||.|...|...|
  Fly   195 HGHSSKTTLFITAFVIPCLVIIACYAKIFWVVHKSEQRLKRHATKQNSIPNNLRPLASTGSGALP 259

Human   250 -----QRQQQVSVDLSFK----------------------------------TKAFTTILILFVG 275
                 |...:||.|.|..                                  ||   .:|.:|:.
  Fly   260 SGAECQPSNRVSSDSSSSFSIDVPETAPSGKQQPTRVKDQREVRAKRNEWRITK---MVLAIFLS 321

Human   276 FSLCWLPHSVYSLLSVFSQRFYCGSSFYATSTCVLWLSYLKSVFNPIVYCWRIKKFREA 334
            |.:|:||.::..:...       .....:...|...|.||.:..|||:|....|::|:|
  Fly   322 FVVCYLPITIVKVADK-------NVEHPSLHICSYILLYLSACINPIIYVIMNKQYRKA 373

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GPR45	NP_009158.3	7tmA_GPR45	35..335	CDD:320525	79/355 (22%)
		TM helix 1	36..62	CDD:320525	6/25 (24%)
		TM helix 2	69..92	CDD:320525	4/22 (18%)
		TM helix 3	107..137	CDD:320525	9/31 (29%)
		TM helix 4	146..168	CDD:320525	8/26 (31%)
		TM helix 5	192..221	CDD:320525	8/30 (27%)
		TM helix 6	260..290	CDD:320525	9/63 (14%)
		TM helix 7	303..328	CDD:320525	8/24 (33%)
moody	NP_001188534.1	7tm_4	44..>167	CDD:304433	31/126 (25%)
		7tm_1	53..363	CDD:278431	71/327 (22%)
		7tm_4	<310..380	CDD:304433	19/74 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910