DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment HPS5 and p

DIOPT Version :9

Sequence 1:XP_011518164.1 Gene:HPS5 / 11234 HGNCID:17022 Length:1156 Species:Homo sapiens
Sequence 2:NP_001303455.1 Gene:p / 41025 FlyBaseID:FBgn0086679 Length:826 Species:Drosophila melanogaster


Alignment Length:568 Identity:152/568 - (26%)
Similarity:250/568 - (44%) Gaps:116/568 - (20%)


- Green bases have known domain annotations that are detailed below.


Human    12 SHVLAEFESLDPLLSALRLDSSRLKCTSIAVSRKWLALGSSGGGLHLIQKEGWKHRLFLSHREGA 76
            ::.|..|......||......:|:|.|...:|..::..|:|.|.|:|..:.| |..|.:.::.||
  Fly     4 AYCLTNFIDFSLSLSLPLKHHNRIKYTCFDISDSYIIFGASSGSLYLFNRNG-KFLLLIPNKHGA 67

Human    77 ISQVACCLHDDDYVAVATSQGLVVVWELNQERRGKPEQMYVSSEHKGRRVTALCWDTAILRVFVG 141
            |:.::... :..|||.||.:.|:.|:.:|...:..|:.::...: :..:||.:.|.....:.:.|
  Fly    68 ITSLSISA-NSKYVAFATQRSLICVYAVNLSAQATPQVIFTHLD-QSVQVTCIHWTQDEKQFYYG 130

Human   142 DHAGKVSAIKLNTSKQAKAAAAFV----MF--PVQTITTVDSCVVQLDYLDGRLLISSLTRSFLC 200
            |..|:||.:.|         ::|:    :|  .|..:..:||.:||:|..:..||:|:.|:..||
  Fly   131 DSRGQVSLVLL---------SSFIGHSLLFNMTVHPLLYLDSPIVQIDDFEYLLLVSNCTKCILC 186

Human   201 DTEREKFWKIGNKERDGEYGACFFPGRCSGGQQPLIYCARPGSRMWEVNFDGEVISTHQFKKLLS 265
            :||.|.:.:|||:.|||.:|||||.......|...|||||||||:|||:|:||||.|||||..|:
  Fly   187 NTEYEDYKQIGNRPRDGAFGACFFVSPQESLQPSRIYCARPGSRVWEVDFEGEVIQTHQFKTALA 251

Human   266 LPPLPVITLRSEP-----QYDHTAG----SSQSLSFPKLLHLSEHCVLTWTERGIYIFIPQNVQV 321
            ..|..:    ..|     :.|..|.    ..|:|.|.|:..|::..:|.:||.|:|||..:...|
  Fly   252 TAPARI----QRPGSGTDELDANAELLDYQPQNLQFAKVQRLNDDFLLAFTELGLYIFDIRRSAV 312

Human   322 LLWSEVKDIQDVAVCR---NELFCLHLNGKVSHLSLISVERCVERLLRRGLWNLAARTCCLFQNS 383
            :|||  ...:.:|.||   :|:|....:|     :|.||:          |..|.:....|.|.|
  Fly   313 VLWS--NQFERIADCRSSGSEIFVFTQSG-----ALYSVQ----------LQTLQSHAVSLIQQS 360

Human   384 VI--------------ASRARKTLTADKLEHLKSQL----DHGTYNDL------ISQLEELILKF 424
            .:              |.:||:.....:|..||..|    ::...||:      |:|.....|..
  Fly   361 KLLPCANLLRQHVRYFADKAREDYELKQLNPLKQLLIERQEYELLNDISVIFDAITQCTGSALDT 425

Human   425 EPLDSACSSRRSSISSHESFSILDSGIYRIISS---------RRGSQSD---------------- 464
            .....:.::...|:|...|......|:|.:.::         :.|...|                
  Fly   426 HSSGGSSATTERSLSGGSSSRAPPKGVYVLENAFCDNLKQPLKTGHFKDALLTVTGKFGKNIIKY 490

Human   465 ------EDSCSLHSQTLSEDER---FKEF-------TSQQEEDLPDQC 496
                  |:...|..:.:...||   ||:.       :..|||::..:|
  Fly   491 KFNIFAEEQQQLVRELIPASERSLPFKDIKARYESGSEDQEEEIVRRC 538

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HPS5XP_011518164.1 WD40 repeat 37..75 CDD:293791 10/37 (27%)
WD40 repeat 81..118 CDD:293791 9/36 (25%)
WD40 repeat 126..165 CDD:293791 9/38 (24%)
WD40 repeat 173..210 CDD:293791 14/36 (39%)
WD40 repeat 218..257 CDD:293791 23/38 (61%)
pNP_001303455.1 WD40 <17..>132 CDD:225201 30/117 (26%)
WD40 <21..128 CDD:295369 27/109 (25%)
WD40 repeat 25..63 CDD:293791 12/38 (32%)
WD40 repeat 68..107 CDD:293791 10/39 (26%)
WD40 repeat 116..154 CDD:293791 10/46 (22%)
WD40 repeat 161..196 CDD:293791 14/34 (41%)
WD40 repeat 204..245 CDD:293791 24/40 (60%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165154191
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3621
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S7859
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0004653
OrthoInspector 1 1.000 - - oto90558
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - LDO PTHR23287
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4159
SonicParanoid 1 1.000 - - X5011
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
109.780

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