Protein Alignment HPS5 and Hps5

DIOPT Version :10

• Sequence 1: NP_001427831.1
• Gene: HPS5 / 11234
• HGNCID: 17022
• Length: 1156
• Species: Homo sapiens
• Sequence 2: NP_001129084.1
• Gene: Hps5 / 308598
• RGDID: 1311916
• Length: 1126
• Species: Rattus norvegicus
• Alignment Length: 1124
• Identity: 893/1124 - (79%)
• Similarity: 985/1124 - (87%)
• Gaps: 9/1124 - (0%)

Human     1 MAFVPVIPESYSHVLAEFESLDPLLSALRLDSSRLKCTSIAVSRKWLALGSSGGGLHLIQKEGWK 65
            |..||||||:|||||||||||||||:|||||||||||:|||||||||||||:||||:||||:|||
  Rat     1 MTSVPVIPEAYSHVLAEFESLDPLLTALRLDSSRLKCSSIAVSRKWLALGSTGGGLNLIQKDGWK 65

Human    66 HRLFLSHREGAISQVACCLHDDDYVAVATSQGLVVVWELNQERRGKPEQMYVSSEHKGRRVTALC 130
            .|||||||||||||:|||.|||||||||||||||||||||||||||||:::||||||||:|||||
  Rat    66 QRLFLSHREGAISQIACCSHDDDYVAVATSQGLVVVWELNQERRGKPERIHVSSEHKGRKVTALC 130

Human   131 WDTAILRVFVGDHAGKVSAIKLNTSKQAKAAAAFVMFPVQTITTVDSCVVQLDYLDGRLLISSLT 195
            ||||:||||||||.||||||||||.|||||||||||||||||.|||||||||||||||||:||||
  Rat   131 WDTAVLRVFVGDHVGKVSAIKLNTLKQAKAAAAFVMFPVQTIITVDSCVVQLDYLDGRLLVSSLT 195

Human   196 RSFLCDTEREKFWKIGNKERDGEYGACFFPGRCSGGQQPLIYCARPGSRMWEVNFDGEVISTHQF 260
            |:||||||||||||||||||:||:|||||||||:|.|||||||||||||:|||:|||||:|||||
  Rat   196 RTFLCDTEREKFWKIGNKEREGEFGACFFPGRCAGSQQPLIYCARPGSRIWEVSFDGEVLSTHQF 260

Human   261 KKLLSLPPLPVITLRSEPQYDHTAGSSQSLSFPKLLHLSEHCVLTWTERGIYIFIPQNVQVLLWS 325
            |||||:|||||||..|||||||..|||||||||||||.||||||||||:||||||||||||||||
  Rat   261 KKLLSMPPLPVITASSEPQYDHAVGSSQSLSFPKLLHFSEHCVLTWTEKGIYIFIPQNVQVLLWS 325

Human   326 EVKDIQDVAVCRNELFCLHLNGKVSHLSLISVERCVERLLRRGLWNLAARTCCLFQNSVIASRAR 390
            ||||||||||.:|||||||.|||:|||||:|||||||||||||||:||||||||||||:|.||.|
  Rat   326 EVKDIQDVAVYKNELFCLHFNGKISHLSLLSVERCVERLLRRGLWDLAARTCCLFQNSIITSRGR 390

Human   391 KTLTADKLEHLKSQLDHGTYNDLISQLEELILKFEPLDSACSSRRSSISSHESFSILDSGIYRII 455
            |||:.|||||||||||....::|||||||:|.|||||||||||||||||||||||||||||||||
  Rat   391 KTLSTDKLEHLKSQLDLTACSELISQLEEVIFKFEPLDSACSSRRSSISSHESFSILDSGIYRII 455

Human   456 SSRRGSQSDEDSCSLHSQTLSEDERFKEFTSQQEEDLPDQCCGSHGNEDNVSHAPVMFETDKNET 520
            |||||||||||||||||||.|||||.|||.|.|||:.|:|.|.::.|.|:|||:|:|.|.||.|.
  Rat   456 SSRRGSQSDEDSCSLHSQTFSEDERLKEFASHQEEEQPEQGCCANRNGDSVSHSPMMSEIDKGEA 520

Human   521 FLPFGIPLPFRSPSPLVSLQAVKESVSSFVRKTTEKIGTLHTSPDLKVRPELRGDEQSCEEDVSS 585
            ||||.|||||||||||:||||||:|||||||||||||||||.||:||...|.|..:|..||:||:
  Rat   521 FLPFNIPLPFRSPSPLLSLQAVKDSVSSFVRKTTEKIGTLHASPELKETSEPRDADQVHEEEVSA 585

Human   586 DTCPKEEDTEEEKEVTSPPPEEDRFQELKVATAEAMTKLQDPLVLFESESLRMVLQEWLSHLEKT 650
            .|||.|||| ||||: ..||||||.|.|:.|||||:|||.|||||||.:.||.||.||||.||||
  Rat   586 VTCPLEEDT-EEKEI-HQPPEEDRLQGLRAATAEAVTKLLDPLVLFEPKLLRAVLHEWLSQLEKT 648

Human   651 FAMKDFSGVSDTDNSSMKLNQDVLLVNESKKGILDEDNEKEKRDSLGNEESVDKTACECVRSPRE 715
            ||||.|:.:|:|.:...|.|.|..|:.||:|.:|.|::.:|:|.:||.||...:|.|:.|.|..|
  Rat   649 FAMKGFAAISNTSSLPEKSNLDTHLLGESEKRVLCEESGEERRVTLGTEEPGGQTTCDSVSSLSE 713

Human   716 SLDDLFQICSPCAIASGLRNDLAELTTLCLELNVLNSKIKSTSGHVDHTLQQYSPEILACQFLKK 780
            ...|.||:|.|.|||:.|:.||.||||||||||||.|.::|.|.|:|..|||.|||.|||:||||
  Rat   714 PSADSFQVCPPYAIANSLQKDLVELTTLCLELNVLTSAVESDSRHMDCALQQLSPETLACRFLKK 778

Human   781 YFFLLNLKRAKESIKLSYSNSPSVWDTFIEGLKEMASSNPVYMEMEKGDLPTRLKLLDDEVPFDS 845
            |||||:|||||||:|||: .||.|||||:|||||||||.|.||||.:.||||.|:|||..||..|
  Rat   779 YFFLLDLKRAKESVKLSH-YSPCVWDTFVEGLKEMASSTPAYMEMGERDLPTGLQLLDGSVPSHS 842

Human   846 PLLVVYATRLYEKFGESALRSLIKFFPSILPSDIIQLCHHHPAEFLAYLDSLVKSRPEDQRSSFL 910
            |||:.:|.|||::|||.|||:||||:|||.||||.|||..|||:||||||||||||||||..|||
  Rat   843 PLLIAFAARLYDRFGEPALRALIKFYPSISPSDIAQLCRRHPAQFLAYLDSLVKSRPEDQWPSFL 907

Human   911 ESLLQPESLRLDWLLLAVSLDAPPSTSTMDDEGYPRPHSHLLSWGYSQLILHLIKLPADFITKEK 975
            |.|||||||||:|||||||.||||||||:||||:|||||||||||||||||.||||||||.||||
  Rat   908 EFLLQPESLRLEWLLLAVSHDAPPSTSTVDDEGHPRPHSHLLSWGYSQLILLLIKLPADFATKEK 972

Human   976 MTDICRSCGFWPGYLILCLELERRREAFTNIVYLNDMSLMEGDNGWIPETVEEWKLLLHLIQSKS 1040
            |||||||.|||||||.||||||||||||||||||||:|||||||||||||:|||||||||:|:|:
  Rat   973 MTDICRSYGFWPGYLTLCLELERRREAFTNIVYLNDVSLMEGDNGWIPETLEEWKLLLHLLQNKN 1037

Human  1041 TRPAPQESLNGSLSDGPSPINVENVALLLAKAMGPDRAWSLLQECGLALELSEKFTRTCDILRIA 1105
            |||||||||||||||||:|||||||||||||||||||||||||||||||||||||||||||||||
  Rat  1038 TRPAPQESLNGSLSDGPTPINVENVALLLAKAMGPDRAWSLLQECGLALELSEKFTRTCDILRIA 1102

Human  1106 EKRQRHL------NCFHFL 1118
            |:|||.|      .|..||
  Rat  1103 ERRQRALIQGMLEKCDRFL 1121

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HPS5	NP_001427831.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	483..503		9/19 (47%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	561..609		27/47 (57%)
Hps5	NP_001129084.1	WD40 repeat	37..75	CDD:293791	32/37 (86%)
		WD40	<38..193	CDD:441893	138/154 (90%)
		WD40 repeat	81..117	CDD:293791	32/35 (91%)
		WD40 repeat	126..165	CDD:293791	35/38 (92%)
		WD40 repeat	173..210	CDD:293791	33/36 (92%)
		WD40 repeat	218..257	CDD:293791	32/38 (84%)