Protein Alignment HPS5 and W09G3.6

DIOPT Version :10

• Sequence 1: NP_001427831.1
• Gene: HPS5 / 11234
• HGNCID: 17022
• Length: 1156
• Species: Homo sapiens
• Sequence 2: NP_493417.1
• Gene: W09G3.6 / 173249
• WormBaseID: WBGene00012369
• Length: 1125
• Species: Caenorhabditis elegans
• Alignment Length: 1175
• Identity: 245/1175 - (20%)
• Similarity: 401/1175 - (34%)
• Gaps: 434/1175 - (36%)

Human     3 FVPVIPESYSHVLAEFESLDPLLSALRLDSS-RLKCTSIAVSRKWLALGSSGGGLHLIQKEGWKH 66
            |:..||   :|.|.|..|||.|  |...:|: |:|.|.:|.:.|.|.||:|.|.:::..:...|.
 Worm    18 FIDRIP---THFLVELTSLDEL--AFPANSTKRVKYTCVASTSKSLCLGTSTGSVYIFSRYAAKS 77

Human    67 R------------LFLSHREGAISQVACCLHDDDYVAVATSQGLVVVWELNQERRGKPEQMYVSS 119
            |            :|.: |:|.||.::.. ..::.:|:....|.|.|.:||   .|:|..:..|:
 Worm    78 RSRTNSGAPVPVQVFTT-RDGQISTISVS-PSEELMAIGGDSGRVSVAQLN---NGQPPTLIYST 137

Human   120 EHKGR---RVTALCWDTAILRVFVGDHAGKVSAIKLNTSKQAKAAAAFVMFPVQTITTVDSCVVQ 181
            ....|   |||||.|...:..|:.|..:|.:...:|.:....:||.       |.:...|..::|
 Worm   138 PGDARSPDRVTALSWSADLKTVYSGHSSGTLHCHRLTSRSVFRAAH-------QKLMKFDGEIIQ 195

Human   182 LDYLDGRLLISSLTRSFLCDTEREKFWKIGNKERD--GEYGACFFPGRCSGGQQPLIYCARPGSR 244
            :|.|...:||::...:.|...|.....::|.|.|.  ...|||:.     .|:...|..|||..|
 Worm   196 IDTLQSHVLIATSLAAHLFHVESGTIQQVGKKTRSSPAPLGACYV-----HGESAFIVAARPNGR 255

Human   245 MWEVNFDGEVISTHQFKKLLSLPPLPVITLRS-----EPQYDHTAGSSQSLSFPKL--LHL---- 298
            :||.|..|.|..|||:::...:|..|.|:.||     ..|:......:|.:|..|:  :|:
 Worm   256 LWEANLVGVVYRTHQYRQSGQIPRAPPISFRSAFPTDSAQFCGLHPDNQDVSLQKIHVIHVDNGG 320

Human   299 SEHCVLTWTERGIYIFIPQNVQVLLWSEVK-DIQDVAVCRNELFCLHLNGK-VSHLSLISVERCV 361
            ....|::.....|.:...:..:|...:|:. ||.||:.|.|::|.|..:.| :...|:...::.:
 Worm   321 GRSLVVSTAGSRICVVEMETSRVTCCAELDYDILDVSTCGNDIFVLLNDSKGLRKFSVFERQKTL 385

Human   362 ERLLRRGLWNLAARTCCLFQNSVIA----------------SRARKTLTADKLE-HLKSQLD--- 406
            |:|..:|::..:|: ..||.:..|.                ||.::|   :||: .|:..||
 Worm   386 EKLNLKGIFMQSAQ-LVLFCSPHITYPMPLLTTIIEGLGTLSRKKET---EKLQLALQKMLDERK 446

Human   407 --HGTYNDLISQLEELILKFEPLDSACSSRRSSI----SSHESFSILDSGIYRIISSRRGSQSDE 465
              ..||::.|.::|               |:.|:    .:.|| ..|.||::|::
 Worm   447 INQSTYDNNIEEME---------------RKESLKKLKKTPES-KKLPSGVHRVL---------- 485

Human   466 DSCSLHSQTLSEDERFKEFTSQQEEDLPDQCCGSHGNEDNVSHAPVMFETDKNETFLPFG----I 526
                   ||.::                   |..:.::.|.|....:.|..::.   |.|    |
 Worm   486 -------QTAAQ-------------------CSGYDDDFNFSTPQALRERSRSS---PCGPESPI 521

Human   527 PLPFRSPSPLVSLQAVKESVSSFVRKTTEKIGTLHTSPDLKVRPELRGDEQSCEEDVSSDTCPKE 591
            ||..|:..| .||:..:|    :.||.    ||    ||:            ||||:........
 Worm   522 PLEKRASEP-ASLELRQE----YWRKN----GT----PDV------------CEEDILHRARQIL 561

Human   592 EDTEEEKEVTSPPPEEDRFQELKVATAEAMTKLQDPLVLFESESLRMVLQEWLSHLEKTFAMKDF 656
            ||...||                               |.|.||||.:||  |..::|
 Worm   562 EDENSEK-------------------------------LVEKESLRTLLQ--LEGIKK------- 586

Human   657 SGVSDTDNSSMKLNQDVLLVNESKKGILDEDNEKEKRDSLGNEESVDKTACECVRSPRESLDDLF 721
                    ..::....|.:.|.:|.
 Worm   587 --------DEIRFTPTVTIANAAKA---------------------------------------- 603

Human   722 QICSPCAIASGLRNDLAELT-TLCLELNVLNSKIKSTSGHVDHTLQQYSPEILACQFLKKYFFLL 785
                           ||||. .:.::|..:     ..||:..::....:||
 Worm   604 ---------------LAELALAVPVDLTAI-----WNSGNSQNSQNPQNPE-------------- 634

Human   786 NLKRAKESIKLSYSNSPSVWDTFIEG-------LKEMASSNPVYMEMEKGD---------LPTRL 834
                 |...|:| .|.|.:......|       .|.:|:..|:.:.:...|         :...:
 Worm   635 -----KNGSKIS-KNPPQIVKVIRPGHRLQTTTTKPIATVTPITVPVANADDVAVNNMGMISEEM 693

Human   835 KLLDDEVPFDSPLLVVYATRLYEKFGESALRSLIKFFPSILPSDIIQLCHH---HPAEFLAYLDS 896
            :...||:..|                                   ::|..|   |.:.  |..|.
 Worm   694 RRKQDEMWLD-----------------------------------LRLTQHIKKHSSH--ANDDV 721

Human   897 LVKSRPEDQRSSFLESLLQPESLRLDWLLLAVSLDAPPS----TSTMDDEGYPRPHSHLLSWGYS 957
            ::.|.|..                        |.:.|.|    |.|...|| |.|.|.
 Worm   722 IITSSPTS------------------------SNNVPKSDTDYTLTTGSEG-PTPTSE------- 754

Human   958 QLILHLIKLPA--DFITKEKMTDICRSCGF---WPGYLIL---CLELERRREAFTNIVYLNDMSL 1014
                |:...|.  |.||....:: |.:||.   |....:|   |......|:.|..
 Worm   755 ----HIWTNPLDDDVITPTSSSN-CATCGMHRSWAATSLLMAVCGGANVLRDEFQR--------- 805

Human  1015 MEGDNGWIPETVEEWKLLL-HLIQSKSTRPA--PQ----------------ESLNGSLSDGPSPI 1060
                ||.||::...|..|| |:....|::.|  |:                ::.||...||..|
 Worm   806 ----NGAIPQSHVAWSTLLRHVASVTSSQEAICPKCEMSLSTVERVCSDAWKTANGMAEDGVRP- 865

Human  1061 NVENV 1065
            |||.:
 Worm   866 NVERI 870

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HPS5	NP_001427831.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	483..503		1/19 (5%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	561..609		10/47 (21%)
W09G3.6	NP_493417.1	WD40	<88..210	CDD:441893	34/133 (26%)
		WD40 repeat	99..134	CDD:293791	10/38 (26%)
		WD40 repeat	147..187	CDD:293791	12/46 (26%)
		RING-H2_Vps	1050..>1088	CDD:438147