Protein Alignment POLG2 and GRS2

DIOPT Version :10

• Sequence 1: NP_009146.2
• Gene: POLG2 / 11232
• HGNCID: 9180
• Length: 485
• Species: Homo sapiens
• Sequence 2: NP_015406.1
• Gene: GRS2 / 856196
• SGDID: S000006285
• Length: 618
• Species: Saccharomyces cerevisiae
• Alignment Length: 596
• Identity: 98/596 - (16%)
• Similarity: 180/596 - (30%)
• Gaps: 263/596 - (44%)

Human   100 GPLGVELRKNLAAEWWTSVVVFREQVFPVDALHHKPGPLL-PGD--------------------- 142
            ||.|.:|:.|| ...|....:..|.:..||      ||:| |.|
Yeast    39 GPPGCQLQNNL-IRLWREHFIMEENMLQVD------GPMLTPYDVLKTSGHVDKFTDWMCRNPKT 96

Human   143 ----SAFRLVSAETLREILQDKELSKEQLVAFLENVLKT-------------------------- 177
                .|..|:. :||::.|.||:::.:.: ..:|.:|.|
Yeast    97 GEYYRADHLIE-QTLKKRLLDKDVNPQDM-KNMEKILTTIDGFSGPELNLVMQEYNINDPVTNDV 159

Human   178 -----------------SGK----LRENLLHGALEHYVNCLDLVNKRLPYGLAQIGVCF------ 215
                             ||:    ||.....|...::...|::...::|:..|.||..|
Yeast   160 LDALTSFNLMFETKIGASGQLKAFLRPETAQGQFLNFNKLLEINQGKIPFASASIGKSFRNEISP 224

Human   216 -------------------------HPVF----------------DTKQIRNGVK-SIGEKTEAS 238
                                     |..|                ::.:::..|| :|||...:.
Yeast   225 RSGLLRVREFLMAEIEHFVDPLNKSHAKFNEVLNEEIPLLSRRLQESGEVQLPVKMTIGEAVNSG 289

Human   239 LVWFTPPRTSNQWLDFWLRHRLQWWRKFAMSPSNFS------------SSDCQDEE--------- 282
            :|       .|:.|.:::....|:.....::...|.            ::||.|.|
Yeast   290 MV-------ENETLGYFMARVHQFLLNIGINKDKFRFRQHLKNEMAHYATDCWDGEILTSYGWIE 347

Human   283 -------------------GR-------------------KGNKLYY--NFPWGKELIET-LWNL 306
                               ||                   :.||.::  .|....:|||: |...
Yeast   348 CVGCADRAAFDLTVHSKKTGRSLTVKQKLDTPKERTEWVVEVNKKFFGSKFKQKAKLIESVLSKF 412

Human   307 GDHELLHMYP-------------GNVSKL--------------HGRDGRKNVVPCVLSVNGDLDR 344
            ...||:..:.             |.:.||              |.|:    .:|.|:..:..|.|
Yeast   413 SQDELIRRHEELEKNGEFTCQVNGQIVKLDSSLVTIKMKTTLQHIRE----YIPNVIEPSFGLGR 473

Human   345 GMLAYLYDSFQLTENSFTRKKNLHRKVLKLHPCLAPIKV---ALDVGRGPTLELRQVCQGLFNEL 406
            .:.......||:..:|.:      |........:|||||   .:....|....|:::.|.|....
Yeast   474 IIYCIFDHCFQVRVDSES------RGFFSFPLQIAPIKVFVTTISNNDGFPAILKRISQALRKRE 532

Human   407 LENGISVWPGY--LETMQSSLEQLYSKYDEMSILFTVLVTETTLENGLIHLRSRD---------- 459
            :         |  ::...:|:.:.|::.||:...|.:.:...|:::..:.||.|:
Yeast   533 I---------YFKIDDSNTSIGKKYARNDELGTPFGITIDFETIKDQTVTLRERNSMRQVRGTIT 588

Human   460 ---TTMKEMMH 467
               :|:.:|:|
Yeast   589 DVISTIDKMLH 599

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
POLG2	NP_009146.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	28..65
		class_II_aaRS-like_core	69..350	CDD:444800	72/459 (16%)
		Pol_gamma_b_Cterm	354..481	CDD:239106	26/132 (20%)
GRS2	NP_015406.1	glyS_dimeric	7..598	CDD:273051	96/593 (16%)