DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment POLG2 and GRS1

DIOPT Version :10

Sequence 1:NP_009146.2 Gene:POLG2 / 11232 HGNCID:9180 Length:485 Species:Homo sapiens
Sequence 2:NP_009679.2 Gene:GRS1 / 852418 SGDID:S000000325 Length:667 Species:Saccharomyces cerevisiae


Alignment Length:459 Identity:86/459 - (18%)
Similarity:144/459 - (31%) Gaps:177/459 - (38%)


- Green bases have known domain annotations that are detailed below.


Human   148 VSAETLREILQDKELSKEQLVAFLENVLKTSGK----LRENLLHGALEHYVNCLDLVNKRLPYGL 208
            |:.|||.        |........|..:..||:    ||.....|...::...|:..|.:.|:..
Yeast   196 VTGETLE--------SPRAFNLMFETAIGPSGQLKGYLRPETAQGQFLNFNKLLEFNNSKTPFAS 252

Human   209 AQIGVCF-------------------------------HPVF-DTKQIRNG-------------- 227
            |.||..|                               ||.| :.|.|:..              
Yeast   253 ASIGKSFRNEISPRAGLLRVREFLMAEIEHFVDPLDKSHPKFNEIKDIKLSFLPRDVQEAGSTEP 317

Human   228 -VKSIGEKTEASLVWFTPPRTSNQWLDFWLRHRLQWWRKFAMSPSNFS------------SSDCQ 279
             ||::||...:.:|       .|:.|.:::....|:..|..:..|...            ::||.
Yeast   318 IVKTVGEAVASRMV-------DNETLGYFIARIYQFLMKIGVDESKLRFRQHMANEMAHYAADCW 375

Human   280 DEEGRKGNKLYYNFPW-----------------GKELIE--------------TLWNLG------ 307
            |.|      |..::.|                 .|:..|              |.|.:.      
Yeast   376 DGE------LKTSYGWIECVGCADRSAYDLTVHSKKTKEKLVVRQKLDNPIEVTKWEIDLTKKLF 434

Human   308 -----------DHELLHMYPGNVS--------------KLHGRDGR------------------- 328
                       :..||:|...:::              |:.|.||.                   
Yeast   435 GPKFRKDAPKVESHLLNMSQDDLASKAELLKANGKFTIKVDGVDGEVELDDKLVKIEQRTKVEHV 499

Human   329 KNVVPCVLSVNGDLDRGMLAYLYDSFQLTENSF-TRKKNLHRKVLKLHPCLAPIKVALDVGRGPT 392
            :..||.|:..:..:.|    .:|..|   |:|| .|.::..|.||...|.:||.||.| |.....
Yeast   500 REYVPSVIEPSFGIGR----IIYSVF---EHSFWNRPEDNARSVLSFPPLVAPTKVLL-VPLSNH 556

Human   393 LELRQVCQGLFNELLENGISVWPGYLETMQSSLEQLYSKYDEMSILFTVLVTETTLENGLIHLRS 457
            .:|..|...:...|.::.|   |..::....|:.:.|::.||:...|.|.:...:.::..:.||.
Yeast   557 KDLVPVTTEVAKILRKSQI---PFKIDDSGVSIGKRYARNDELGTPFGVTIDFESAKDHSVTLRE 618

Human   458 RDTT 461
            ||:|
Yeast   619 RDST 622

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
POLG2NP_009146.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 28..65
class_II_aaRS-like_core 69..350 CDD:444800 54/345 (16%)
Pol_gamma_b_Cterm 354..481 CDD:239106 31/109 (28%)
GRS1NP_009679.2 glyS_dimeric 15..640 CDD:273051 86/459 (19%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.