Protein Alignment POLG2 and Polg2

DIOPT Version :10

• Sequence 1: NP_009146.2
• Gene: POLG2 / 11232
• HGNCID: 9180
• Length: 485
• Species: Homo sapiens
• Sequence 2: NP_056625.2
• Gene: Polg2 / 50776
• MGIID: 1354947
• Length: 459
• Species: Mus musculus
• Alignment Length: 485
• Identity: 354/485 - (72%)
• Similarity: 398/485 - (82%)
• Gaps: 26/485 - (5%)

Human     1 MRSRVAVRACHKVCRCLLSGFGGRVDAGQPELLTERSSPKGGHVKSHAELEGNGEHPEAPGSGEG 65
            ||.....|||.:.|||.|||:.|..|..|                          .|:||.....
Mouse     1 MRCGGGARACRRACRCWLSGYAGPADGTQ--------------------------QPDAPEHAVA 39

Human    66 SEALLEICQRRHFLSGSKQQLSRDSLLSGCHPGFGPLGVELRKNLAAEWWTSVVVFREQVFPVDA 130
            .|||:::|:||||.||:.||||..:||||||..|||||||||||||::||:|:||||||||.||:
Mouse    40 REALVDLCRRRHFFSGTPQQLSTAALLSGCHARFGPLGVELRKNLASQWWSSMVVFREQVFAVDS 104

Human   131 LHHKPGPLLPGDSAFRLVSAETLREILQDKELSKEQLVAFLENVLKTSGKLRENLLHGALEHYVN 195
            ||.:||...|.||||||||.|::||||||:|.|||||||||||:||||||||..|||||||||||
Mouse   105 LHQEPGSSQPRDSAFRLVSPESIREILQDREPSKEQLVAFLENLLKTSGKLRATLLHGALEHYVN 169

Human   196 CLDLVNKRLPYGLAQIGVCFHPVFDTKQIRNGVKSIGEKTEASLVWFTPPRTSNQWLDFWLRHRL 260
            ||||||::||:||||||||||||.::.|..:.|..:|||||||||||||.|||:|||||||||||
Mouse   170 CLDLVNRKLPFGLAQIGVCFHPVSNSNQTPSSVTRVGEKTEASLVWFTPTRTSSQWLDFWLRHRL 234

Human   261 QWWRKFAMSPSNFSSSDCQDEEGRKGNKLYYNFPWGKELIETLWNLGDHELLHMYPGNVSKLHGR 325
            .||||||||||||||:|||||.||||:||||:||||||.|||||||||.||||.||||||.:.||
Mouse   235 LWWRKFAMSPSNFSSADCQDELGRKGSKLYYSFPWGKEPIETLWNLGDQELLHTYPGNVSTIQGR 299

Human   326 DGRKNVVPCVLSVNGDLDRGMLAYLYDSFQLTENSFTRKKNLHRKVLKLHPCLAPIKVALDVGRG 390
            |||||||||||||:||:|.|.||||||||||.||||.|||:|.||||||||||||||||||||:|
Mouse   300 DGRKNVVPCVLSVSGDVDLGTLAYLYDSFQLAENSFARKKSLQRKVLKLHPCLAPIKVALDVGKG 364

Human   391 PTLELRQVCQGLFNELLENGISVWPGYLETMQSSLEQLYSKYDEMSILFTVLVTETTLENGLIHL 455
            ||:|||||||||.||||||||||||||.||:.||||||:|||||||:||:|||||||||||||.|
Mouse   365 PTVELRQVCQGLLNELLENGISVWPGYSETVHSSLEQLHSKYDEMSVLFSVLVTETTLENGLIQL 429

Human   456 RSRDTTMKEMMHISKLKDFLIKYISSAKNV 485
            ||||||||||||||||:|||:||::||.||
Mouse   430 RSRDTTMKEMMHISKLRDFLVKYLASASNV 459

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
POLG2	NP_009146.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	28..65		4/36 (11%)
		class_II_aaRS-like_core	69..350	CDD:444800	217/280 (78%)
		Pol_gamma_b_Cterm	354..481	CDD:239106	109/126 (87%)
Polg2	NP_056625.2	GlyRS-like_core	43..324	CDD:238397	217/280 (78%)
		Pol_gamma_b_Cterm	328..455	CDD:239106	109/126 (87%)