DRSC/TRiP Functional Genomics Resources

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Protein Alignment POLG2 and PolG2

DIOPT Version :10

Sequence 1:NP_009146.2 Gene:POLG2 / 11232 HGNCID:9180 Length:485 Species:Homo sapiens
Sequence 2:NP_001027262.1 Gene:PolG2 / 3772064 FlyBaseID:FBgn0004407 Length:361 Species:Drosophila melanogaster


Alignment Length:351 Identity:85/351 - (24%)
Similarity:130/351 - (37%) Gaps:77/351 - (21%)


- Green bases have known domain annotations that are detailed below.


Human   183 ENLLHGALEHYVNCLDLVNKRLPYGLAQIGVCFHPVF----------DTKQIRNG----VKSIGE 233
            |.|.||  ..|...|.....||....|.:|....|:.          .::|.||.    ||....
  Fly    26 ELLSHG--REYAKLLQQHWTRLRPLAAHLGATKEPINPVNIQRFSFPQSQQFRNNFQKLVKDHPR 88

Human   234 K----------------TEASLVWFTPPRTSNQWLDFWLR-HR-------LQ-----WWRKFAMS 269
            |                |..||.....| |.:...||.:. ||       :|     ||.:.:.:
  Fly    89 KAKCPTLLKHQSTCSGPTSNSLFGIKGP-TLHLTTDFLVEPHRALEHFYNMQRESKIWWMRLSSN 152

Human   270 PSNFSSSDCQDEEGRKGNKLYYNFPWGKELIETLWNLGDH--------ELLHMYPGNVSKLHGRD 326
            ||.:....|...|....|..        :.|:...:.||.        .|:.:......:|....
  Fly   153 PSRYRIVPCDLAEDLNPNDY--------QAIDIRTSYGDAGEVTVEQLSLVRIVDDKDFRLPDAR 209

Human   327 GRKNVVPCVLSVNGDLDRGMLAYLYDSFQLTENSFTRKKNLHRKVLKLHPCLAPIK---VALDVG 388
            ..:.|.|.|:....:|:....|.|.|......:|         :.|.||..|||.:   ..::..
  Fly   210 TGEIVQPTVIRSVIELETTTCALLLDGCDHGRDS---------QSLLLHRVLAPYQCGIACVESD 265

Human   389 RGPTLELRQVCQGLFNELLENG--ISVWPGYLETMQSS-LEQLYSKYDEMSILFTVLVTETTLEN 450
            ...:.:|..:||.|.:.|...|  :|...|...|..:| |.:...:.|.:.|.:|:::.|.||.|
  Fly   266 SELSADLSDLCQHLKHVLNHAGLRLSEGDGIRTTKNASHLAEHLLETDMLGIPYTLVINEQTLRN 330

Human   451 GLIHLRSRDTTMKEMMHISKLKDFLI 476
            ||:.||||||.:.|.:|||.:.|:|:
  Fly   331 GLMQLRSRDTRLAETIHISDVPDYLL 356

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
POLG2NP_009146.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 28..65
class_II_aaRS-like_core 69..350 CDD:444800 44/217 (20%)
Pol_gamma_b_Cterm 354..481 CDD:239106 39/129 (30%)
PolG2NP_001027262.1 Pol_gamma_b_Cterm 228..361 CDD:239106 42/138 (30%)
Blue background indicates that the domain is not in the aligned region.

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