Protein Alignment POLG2 and Polg2

DIOPT Version :10

• Sequence 1: NP_009146.2
• Gene: POLG2 / 11232
• HGNCID: 9180
• Length: 485
• Species: Homo sapiens
• Sequence 2: NP_001100530.1
• Gene: Polg2 / 303612
• RGDID: 1305128
• Length: 459
• Species: Rattus norvegicus
• Alignment Length: 482
• Identity: 353/482 - (73%)
• Similarity: 398/482 - (82%)
• Gaps: 26/482 - (5%)

Human     1 MRSRVAVRACHKVCRCLLSGFGGRVDAGQPELLTERSSPKGGHVKSHAELEGNGEHPEAPGSGEG 65
            |.|....|||.:.|||.|||:.|..|..|                          .|..|.....
  Rat     1 MHSGGVARACRRACRCWLSGYAGPTDGTQ--------------------------QPTDPEHALA 39

Human    66 SEALLEICQRRHFLSGSKQQLSRDSLLSGCHPGFGPLGVELRKNLAAEWWTSVVVFREQVFPVDA 130
            .|||:::|:|||||||:.||||..:||||||.||||||||||||||::||:|:||||||||.||:
  Rat    40 REALVDLCRRRHFLSGTPQQLSTAALLSGCHSGFGPLGVELRKNLASQWWSSMVVFREQVFAVDS 104

Human   131 LHHKPGPLLPGDSAFRLVSAETLREILQDKELSKEQLVAFLENVLKTSGKLRENLLHGALEHYVN 195
            |||:||...|.||||||||.|.:||||||||||||||||||||:|||||||||.||||||||||:
  Rat   105 LHHEPGSSQPRDSAFRLVSPECIREILQDKELSKEQLVAFLENLLKTSGKLRETLLHGALEHYVH 169

Human   196 CLDLVNKRLPYGLAQIGVCFHPVFDTKQIRNGVKSIGEKTEASLVWFTPPRTSNQWLDFWLRHRL 260
            ||||||::|||||||||||||||.:.|:|.|.|..:|||||||||||||.|||:|||||||||||
  Rat   170 CLDLVNRKLPYGLAQIGVCFHPVLNPKEIPNSVTRVGEKTEASLVWFTPTRTSSQWLDFWLRHRL 234

Human   261 QWWRKFAMSPSNFSSSDCQDEEGRKGNKLYYNFPWGKELIETLWNLGDHELLHMYPGNVSKLHGR 325
            .||||||:|||||||.||||..||||.:|||:||||||.:||||:||:.|||::|||:||.:.||
  Rat   235 LWWRKFAVSPSNFSSVDCQDGSGRKGCRLYYSFPWGKEPLETLWDLGEQELLNVYPGDVSAIQGR 299

Human   326 DGRKNVVPCVLSVNGDLDRGMLAYLYDSFQLTENSFTRKKNLHRKVLKLHPCLAPIKVALDVGRG 390
            ||||||||.|||||||||.|.|||||||||.|||||:|||:|.||||||||||||||||||||:|
  Rat   300 DGRKNVVPSVLSVNGDLDLGTLAYLYDSFQFTENSFSRKKSLQRKVLKLHPCLAPIKVALDVGKG 364

Human   391 PTLELRQVCQGLFNELLENGISVWPGYLETMQSSLEQLYSKYDEMSILFTVLVTETTLENGLIHL 455
            ||:|||||||||.||||||||:||||||||.|||||||||||||||||||||:||||||:|||.|
  Rat   365 PTVELRQVCQGLLNELLENGIAVWPGYLETAQSSLEQLYSKYDEMSILFTVLITETTLESGLIQL 429

Human   456 RSRDTTMKEMMHISKLKDFLIKYISSA 482
            ||||||||||||||:|:|||:||::||
  Rat   430 RSRDTTMKEMMHISRLRDFLVKYLASA 456

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
POLG2	NP_009146.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	28..65		3/36 (8%)
		class_II_aaRS-like_core	69..350	CDD:444800	218/280 (78%)
		Pol_gamma_b_Cterm	354..481	CDD:239106	110/126 (87%)
Polg2	NP_001100530.1	class_II_aaRS-like_core	43..324	CDD:444800	218/280 (78%)
		Pol_gamma_b_Cterm	328..455	CDD:239106	110/126 (87%)