DRSC/TRiP Functional Genomics Resources

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Protein Alignment POLG2 and grs1

DIOPT Version :10

Sequence 1:NP_009146.2 Gene:POLG2 / 11232 HGNCID:9180 Length:485 Species:Homo sapiens
Sequence 2:NP_593935.1 Gene:grs1 / 2543181 PomBaseID:SPAC3F10.03 Length:652 Species:Schizosaccharomyces pombe


Alignment Length:626 Identity:112/626 - (17%)
Similarity:197/626 - (31%) Gaps:264/626 - (42%)


- Green bases have known domain annotations that are detailed below.


Human    71 EICQRRHFLSGSKQQLSRDSLLSGCHPGFGPLGVELRKNLAAEWWTSVVVFREQVFPVDALHHKP 135
            |:.::|.|.|.|.|....   :||.: .:||.|..|:.|| .:.|....|..|.:..||.....|
pombe    17 ELMKKRFFFSPSFQIYGG---ISGLY-DYGPPGSALQSNL-VDIWRKHFVIEESMLEVDCSMLTP 76

Human   136 GPLL---------------------------------------------------PGDSAFRLVS 149
            ..:|                                                   |.:|..:...
pombe    77 HEVLKTSGHVDKFADWMCKDPATGEIFRADHLVEEVLEARLKGDKEARGQNSNDQPEESDDKKKR 141

Human   150 AETLREI----LQDKELSK-EQLVAFLEN--------VLK--------TSGKLRE----NLL--- 186
            .:.::||    |.||.:.: |.::|.::|        ::|        |:|:|..    ||:   
pombe   142 KKKVKEIRATRLDDKTVEEYEFILAQIDNYDGDQLGELMKKYDIRNPATNGELETPRQFNLMFET 206

Human   187 ----HGALEHYV-------------NCLDLVNKRLPYGLAQIGVCFHPVFDTKQIRNGVKSIGEK 234
                .|.|:.|:             ..|:..|.::|:..|.:|..|......   |:|:..:.|.
pombe   207 QIGPSGGLKGYLRPETAQGQFLNFSRLLEFNNGKVPFASAMVGKAFRNEISP---RSGLLRVREF 268

Human   235 TEASLVWFTPPR-------------------------------------------TSNQWLDFWL 256
            ..|.:..|..|:                                           ..|..|.:::
pombe   269 LMAEVEHFVDPKNKEHDRFDEVSHMPLRLLPRGVQLEGKTDILEMPIGDAVKKGIVDNTTLGYFM 333

Human   257 -------------RHRLQWWRKFAMSPSNFSSSDCQDEEGRKGNKLYYNFPWGKELIE------- 301
                         .:|:::.:..:...::: :.||.|.|      :..::.|    ||       
pombe   334 ARISLFLEKIGIDMNRVRFRQHMSNEMAHY-ACDCWDAE------IQCSYGW----IECVGCADR 387

Human   302 TLWNLGDH-----------ELLHMYPGNVSKLHGRDGRKNVVP---------------------- 333
            :.::|..|           |.| ..|..|.:......||...|                      
pombe   388 SAYDLSVHSKATKTPLVVQEAL-PEPVVVEQFEVEVNRKKFGPRFKRDAKAVEEAMISWPESEKV 451

Human   334 -----------CVLSVNG-------DL------------------------DRGMLAYLYDSFQL 356
                       .:::|||       ||                        ..|.:.|:     |
pombe   452 EKSAQLVAEGKIIVNVNGVEHTVESDLVTIEKRKHTEHIRTYTPNVIEPSFGLGRILYV-----L 511

Human   357 TENSF-TRKKNLHRKVLKLHPCLAPIKVALDVGRGPTLELRQVCQGLFNELLENGISVWPGYLET 420
            .|::: ||.::::|.||.....:|||| ||.|......|.....:.|..:|...|||   ..::.
pombe   512 MEHAYWTRPEDVNRGVLSFPASIAPIK-ALIVPLSRNAEFAPFVKKLSAKLRNLGIS---NKIDD 572

Human   421 MQSSLEQLYSKYDEMSILFTVLVTETTLENGLIHLRSRDTT 461
            ..:::.:.|::.||:...|.:.|...||:|..|.||.||:|
pombe   573 SNANIGRRYARNDELGTPFGLTVDFETLQNETITLRERDST 613

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
POLG2NP_009146.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 28..65
class_II_aaRS-like_core 69..350 CDD:444800 77/512 (15%)
Pol_gamma_b_Cterm 354..481 CDD:239106 34/109 (31%)
grs1NP_593935.1 PLN02734 3..644 CDD:178335 112/626 (18%)
Blue background indicates that the domain is not in the aligned region.

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