Protein Alignment POLG2 and gars-1

DIOPT Version :10

• Sequence 1: NP_009146.2
• Gene: POLG2 / 11232
• HGNCID: 9180
• Length: 485
• Species: Homo sapiens
• Sequence 2: NP_498093.1
• Gene: gars-1 / 175703
• WormBaseID: WBGene00001744
• Length: 742
• Species: Caenorhabditis elegans
• Alignment Length: 641
• Identity: 116/641 - (18%)
• Similarity: 198/641 - (30%)
• Gaps: 221/641 - (34%)

Human    33 LTERSSPKGGHVKSHAELEG------NGEHPEAPGSGEGSEALLE-ICQRRHFLSGSKQQLSRDS 90
            |..:.:||....|:..||:.      :.|...||.........|| :.:||.|..   |..:...
 Worm    91 LKAKGAPKIDIDKAVVELKARKRLLEDTEIALAPKEASFDRLKLEDLLKRRFFYD---QSFAIYG 152

Human    91 LLSGCHPGFGPLGVELRKNLAAEWWTSVVVFREQVFPVDALHHKPGPLLPGD------------- 142
            .::|.: .|||:|..|:.|:..| |....:..|.:..||.....|.|:|...
 Worm   153 GVTGLY-DFGPMGCSLKANMLQE-WRKHFILEEGMLEVDCTSLTPEPVLKASGHVDRFADWMVKD 215

Human   143 ----SAFRL--VSAETLREILQDKELSK------EQLVAFLEN---------VLKTSGK------ 180
                ..||.  :...::.::|.||:.|.      :.::|.||.         :.:.:.|
 Worm   216 MKNGECFRADHLIKNSIEKLLNDKKTSAAVKQDGQDVLARLEGFDNKDMHEVITRFNFKSPITGN 280

Human   181 -------------------------LRENLLHGALEHYVNCLDLVNKRLPYGLAQIGVCFHPVFD 220
                                     ||.....|...::...|:....:||:..||||:.|.....
 Worm   281 DLTEPIAFNLMFPTQIGPTGDFKAFLRPETAQGIFVNFKRLLEFNQGKLPFAAAQIGLGFRNEIS 345

Human   221 TKQIRNGVKSIGEKTEASLVWFTPPR--------------------------------------- 246
            .:|   |:..:.|.|...:..|..|.
 Worm   346 PRQ---GLIRVREFTMCEIEHFVDPEDKSLAKFAKVADQKLVLFSACNQLDGAPAQEVAIGEAVA 407

Human   247 ---TSNQWLDFWLRHRLQWWRK---------FAMSPSN---FSSSDCQDEE-----------GRK 285
               .:|:.|.:::....|:..|         |....||   ..:.||.|.|           |..
 Worm   408 KKTVANETLGYYMARCHQFLMKVGIDGRRLRFRQHLSNEMAHYAQDCWDAEILTSYGWIECVGNA 472

Human   286 GNKLY------------------------YNFP--------WGKE-------------------- 298
            ....|                        .||.        .||.
 Worm   473 DRACYDLQQHYKATNVKLVAEKKLPEPVDVNFVEAQANMALLGKSFKKDAKKIQTSLQQLTSEQV 537

Human   299 -------LIETLWNL---GDHELLHMYPGNVSKLHGRDGRKNVVPCVLSVNGDLDRGMLAYLYDS 353
                   |.:.|:||   |.:..|.....|:.|...:...:.:.|.|:..:..:.|.|.|.|..|
 Worm   538 SALEEELLAKKLYNLSVDGQNYALTPEHLNIKKYTKKIHVQEITPSVIEPSYGIGRIMYALLEHS 602

Human   354 FQLTENSFTRKKNLHRKVLKLHPCLAPIKVA-LDVGRGPTLELRQVCQGLFNELLENGISVWPGY 417
            |:      .|:.:..|..|...|.:||||.: |.:....|  |..|...:..||....:|.   .
 Worm   603 FR------QREGDEQRTFLAFKPLVAPIKCSVLPISANDT--LIPVMDAVKEELSRFEMSY---K 656

Human   418 LETMQSSLEQLYSKYDEMSILFTVLVTETTLENG--LIHLRSRDTTMKEMMHISKL 471
            ::....::.:.|::.||:.|.|.:.|...:|:..  .:.:|..:|..:..:.:|:|
 Worm   657 VDDSSGTIGRRYARTDEIGIPFGITVDFDSLKTTPFTVTIRHAETMSQIRLEVSEL 712

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
POLG2	NP_009146.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	28..65		9/37 (24%)
		class_II_aaRS-like_core	69..350	CDD:444800	78/473 (16%)
		Pol_gamma_b_Cterm	354..481	CDD:239106	27/121 (22%)
gars-1	NP_498093.1	PLN02734	69..742	CDD:178335	116/641 (18%)