Protein Alignment POLG2 and polg2

DIOPT Version :10

• Sequence 1: NP_009146.2
• Gene: POLG2 / 11232
• HGNCID: 9180
• Length: 485
• Species: Homo sapiens
• Sequence 2: XP_031750242.1
• Gene: polg2 / 100493143
• XenbaseID: XB-GENE-1009985
• Length: 459
• Species: Xenopus tropicalis
• Alignment Length: 428
• Identity: 223/428 - (52%)
• Similarity: 290/428 - (67%)
• Gaps: 10/428 - (2%)

Human    59 APGSGEGSEALLEICQRRHFLSGSKQQLSRDSLLSGCHPGFGPLGVELRKNLAAEWWTSVVVFRE 123
            |.|:....::||.:||.|||:||...  |..|||.|.| ..||||||||:||.::||.|||:.||
 Frog    41 AAGTAHKQDSLLRLCQERHFISGGAP--SHTSLLQGGH-SLGPLGVELRRNLLSQWWNSVVLHRE 102

Human   124 QVFPVDALHHKPGPLLPGDSAFRLVSAETLREILQDKELSKEQLVAFLENVLKTSGKLRENLLHG 188
            ||..:|.....|.|.:..::....:..:.|      ..|..:|....|...:...|.||..||:|
 Frog   103 QVLAIDTALQLPNPSIAPEAPLLAICTQHL------LGLPPQQRGTCLGGPVGKCGVLRHELLYG 161

Human   189 ALEHYVNCLDLVNKRLPYGLAQIGVCFHPVFDTKQIRNGVKSIGEKTEASLVWFTPPRTSNQWLD 253
            ||..||..::|:||:||:|||:||.||||:.:..........|||:|.||||||..|::|.||.|
 Frog   162 ALMEYVPSMELLNKKLPFGLAEIGKCFHPIPEVANEGTIPPRIGERTVASLVWFISPKSSGQWQD 226

Human   254 FWLRHRLQWWRKFAMSPSNFSSSDCQDE-EGRKGNKLYYNFPWGKELIETLWNLGDHELLHMYPG 317
            :|||||||||:|||.|||.|...:.:.| :|.|.:.:.|.||||:|.||||.::.|..||.|:.|
 Frog   227 YWLRHRLQWWQKFAQSPSGFGCREIEQEGQGGKISVIQYEFPWGRETIETLCSMDDSALLQMHSG 291

Human   318 NVSKLHGRDGRKNVVPCVLSVNGDLDRGMLAYLYDSFQLTENSFTRKKNLHRKVLKLHPCLAPIK 382
            :.:||..|||||.|||.||.|:||||||:||||.|:.|.||....|.:...|:||||||.|||||
 Frog   292 SSTKLQARDGRKWVVPHVLWVSGDLDRGLLAYLSDALQQTEGPPVRGRYQQREVLKLHPTLAPIK 356

Human   383 VALDVGRGPTLELRQVCQGLFNELLENGISVWPGYLETMQSSLEQLYSKYDEMSILFTVLVTETT 447
            ||:|:|:|||.|||.|||||..||.|:|:.|||||.|::|.||||||:|||:|.:||||||:|.|
 Frog   357 VAVDMGKGPTGELRLVCQGLSTELREHGVYVWPGYQESLQGSLEQLYTKYDQMGVLFTVLVSEAT 421

Human   448 LENGLIHLRSRDTTMKEMMHISKLKDFLIKYISSAKNV 485
            |||||:..|||||.:||.:|:|||||||:.||::|.::
 Frog   422 LENGLLQARSRDTALKETVHVSKLKDFLLTYIAAATHL 459

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
POLG2	NP_009146.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	28..65		2/5 (40%)
		class_II_aaRS-like_core	69..350	CDD:444800	135/281 (48%)
		Pol_gamma_b_Cterm	354..481	CDD:239106	82/126 (65%)
polg2	XP_031750242.1	class_II_aaRS-like_core	54..324	CDD:444800	133/278 (48%)
		Pol_gamma_b_Cterm	328..455	CDD:239106	82/126 (65%)