Protein Alignment RASSF8 and RASSF8

DIOPT Version :10

• Sequence 1: NP_001158218.1
• Gene: RASSF8 / 11228
• HGNCID: 13232
• Length: 419
• Species: Homo sapiens
• Sequence 2: NP_651411.1
• Gene: RASSF8 / 43096
• FlyBaseID: FBgn0261986
• Length: 607
• Species: Drosophila melanogaster
• Alignment Length: 628
• Identity: 147/628 - (23%)
• Similarity: 241/628 - (38%)
• Gaps: 230/628 - (36%)

Human     1 MELKVWVDGVQRIVCGVTEVTTCQEVVIALAQAIGRTGRYTLIEKWRDTERHLAPHENPIISLNK 65
            |||||||:|:||||||||..||||:||.|||.|.|:.||:||||:||:.||||||:|||:..|.|
  Fly     1 MELKVWVEGIQRIVCGVTVNTTCQDVVFALAHATGKVGRFTLIERWRNNERHLAPNENPMKLLLK 65

Human    66 WGQYASDVQLILRRT----------------------------------GPS------------- 83
            ||:||:|||.||:|:                                  ||:
  Fly    66 WGEYANDVQFILQRSENKTQQQQQQQQQQQQNNNNNNNYAVMTTTKKPLGPNNNNNNKPAPTLLK 130

Human    84 ------LSERPTS-------------DS---VARIPER--------TLYRQSLPPLAKLRPQIDK 118
                  ||.|...             |:   |..||::        .:...:.||..:|.||.:.
  Fly   131 QKSNVELSYRTKELKKSFGGHDAKQFDNIGIVKGIPQQQQLQSQQTAMGAPASPPQEQLTPQDNN 195

Human   119 SIKRREPK-RKSL------TFTGG-----AKGLMDIFGKGKETE--------------------- 150
            ::....|| .|||      |.||.     ..|..|.:.....:.
  Fly   196 NVAPLVPKHEKSLSNPLDMTSTGSNPPAPTNGYNDFYNNNSSSNQHIYSQLSKSSNELRRSSPNE 260

Human   151 -------------------FKQ------------------------------------------- 153
                               :||
  Fly   261 MYYNNNNNIVNNNNNSPELYKQTPTISANGALVPPPYRDPPPPRNSPMCQGQRLASSNADTMSNA 325

Human   154 --------------------KVLNNCK-----------TTADELKKLIRLQTEKLQSIEKQLESN 187
                                .:.||.:           |..::|.:||:.|.||:.:.:.:|:..
  Fly   326 SSSTNPFLSDYDQHSSHNTNSINNNSQAMEEGEPMFQTTQYNDLLQLIKFQREKITAQQMELQKF 390

Human   188 EIEIRFWEQKYNSNLEE------EIVRLEQKIKRNDVEIEEEEFWENELQIEQENEKQLKDQLQE 246
            :.||.:.|.|...:..|      ||.:.:|..::...:::..::.|.|.::.::.||.||.::..
  Fly   391 DTEIVYLESKERDHAHELDAISREISKADQIFRQGSEQLQTLQYVEEENELVKQQEKTLKSEIAL 455

Human   247 IRQKITECENKLKDYLAQIRTMESGLEAEKLQREVQEAQVNEEEVKGKIGKVKGEIDIQGQQSLR 311
            :|.|:..||.:|.....::|.:...:|.|:..::....|..|.:...::.:::.|||.....:..
  Fly   456 LRSKLANCETELLQCKNKMRLLMDDIELEQQHQQQTNRQTVERDFLMEMERIQSEIDQALHNTDT 520

Human   312 LENGIKAVERSLGQATKRLQDKEQELEQLTKELRQVNLQQFIQQTGTKVTVLPAEPIEIEASHAD 376
            ......::::.|......:.||::::|||..|:::||||        .:||...|    |..|.
  Fly   521 SNKTADSLKKELLMIEHAIADKKRQVEQLVNEMKEVNLQ--------SLTVTTTE----EIKHL- 572

Human   377 IEREAPFQSGSLKRPGSSRQLPSNLRILQNPISSGFNPEGIYV 419
              .|.|      .:.||||::..:.|.|:..:.:..||.|::|
  Fly   573 --LEGP------NKQGSSRRIIGSPRQLETAVPTSKNPHGVWV 607

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RASSF8	NP_001158218.1	RA_RASSF8	2..83	CDD:340551	56/114 (49%)
		SMC_prok_B	<164..>384	CDD:274008	52/225 (23%)
RASSF8	NP_651411.1	RA_RASSF8	2..83	CDD:340551	56/114 (49%)
		DR0291	386..>556	CDD:441187	10/34 (29%)