DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FZD10 and Fzd10

DIOPT Version :9

Sequence 1:	NP_009128.1	Gene:	FZD10 / 11211	HGNCID:	4039	Length:	581	Species:	Homo sapiens
Sequence 2:	NP_780493.1	Gene:	Fzd10 / 93897	MGIID:	2136761	Length:	582	Species:	Mus musculus

Alignment Length:	582	Identity:	540/582 - (92%)
Similarity:	560/582 - (96%)	Gaps:	1/582 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     1 MQRPGPRLWLVLQVM-GSCAAISSMDMERPGDGKCQPIEIPMCKDIGYNMTRMPNLMGHENQREA 64
            ||.|||||||||||| |||.||||||:||||||||||:|||||||||||.|||||||||||||||
Mouse     1 MQHPGPRLWLVLQVMIGSCTAISSMDLERPGDGKCQPVEIPMCKDIGYNTTRMPNLMGHENQREA 65

Human    65 AIQLHEFAPLVEYGCHGHLRFFLCSLYAPMCTEQVSTPIPACRVMCEQARLKCSPIMEQFNFKWP 129
            ||||||||||||||||.|||||||||||||||||||||||||||||||||||||||||||.|:||
Mouse    66 AIQLHEFAPLVEYGCHSHLRFFLCSLYAPMCTEQVSTPIPACRVMCEQARLKCSPIMEQFKFRWP 130

Human   130 DSLDCRKLPNKNDPNYLCMEAPNNGSDEPTRGSGLFPPLFRPQRPHSAQEHPLKDGGPGRGGCDN 194
            |||||.|||||||||||||||||||||||:||||:|||||||||||||||||||||||||.||||
Mouse   131 DSLDCSKLPNKNDPNYLCMEAPNNGSDEPSRGSGMFPPLFRPQRPHSAQEHPLKDGGPGRAGCDN 195

Human   195 PGKFHHVEKSASCAPLCTPGVDVYWSREDKRFAVVWLAIWAVLCFFSSAFTVLTFLIDPARFRYP 259
            ||||||||||.||||||||||||||||:||||||||||||:||||||||||||||||||:|||||
Mouse   196 PGKFHHVEKSESCAPLCTPGVDVYWSRDDKRFAVVWLAIWSVLCFFSSAFTVLTFLIDPSRFRYP 260

Human   260 ERPIIFLSMCYCVYSVGYLIRLFAGAESIACDRDSGQLYVIQEGLESTGCTLVFLVLYYFGMASS 324
            ||||||||||||||||||:||||||||||||||||||||||||||||||||||||||||||||||
Mouse   261 ERPIIFLSMCYCVYSVGYIIRLFAGAESIACDRDSGQLYVIQEGLESTGCTLVFLVLYYFGMASS 325

Human   325 LWWVVLTLTWFLAAGKKWGHEAIEANSSYFHLAAWAIPAVKTILILVMRRVAGDELTGVCYVGSM 389
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   326 LWWVVLTLTWFLAAGKKWGHEAIEANSSYFHLAAWAIPAVKTILILVMRRVAGDELTGVCYVGSM 390

Human   390 DVNALTGFVLIPLACYLVIGTSFILSGFVALFHIRRVMKTGGENTDKLEKLMVRIGLFSVLYTVP 454
            ||||||||||:|||||||||||||||||||||||||||||||||||||||||||||:||:|||||
Mouse   391 DVNALTGFVLVPLACYLVIGTSFILSGFVALFHIRRVMKTGGENTDKLEKLMVRIGVFSLLYTVP 455

Human   455 ATCVIACYFYERLNMDYWKILAAQHKCKMNNQTKTLDCLMAASIPAVEIFMVKIFMLLVVGITSG 519
            |||||||||||||||||||:||.||||||||||||.||||..||||||:||||:.||||||||||
Mouse   456 ATCVIACYFYERLNMDYWKMLATQHKCKMNNQTKTPDCLMTTSIPAVEVFMVKVSMLLVVGITSG 520

Human   520 MWIWTSKTLQSWQQVCSRRLKKKSRRKPASVITSGGIYKKAQHPQKTHHGKYEIPAQSPTCV 581
            :|:||||||||||.||||.||:|||||||||:||.|||||||||||.|.||||:|||...||
Mouse   521 VWVWTSKTLQSWQHVCSRGLKRKSRRKPASVVTSAGIYKKAQHPQKPHLGKYELPAQPSACV 582

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FZD10	NP_009128.1	CRD_FZ10	30..156	CDD:143571	119/125 (95%)
		7tmF_FZD10	217..535	CDD:320165	299/317 (94%)
		TM helix 1	226..251	CDD:320165	23/24 (96%)
		TM helix 2	260..281	CDD:320165	19/20 (95%)
		TM helix 3	310..336	CDD:320165	25/25 (100%)
		TM helix 4	353..369	CDD:320165	15/15 (100%)
		TM helix 5	391..420	CDD:320165	27/28 (96%)
		TM helix 6	440..467	CDD:320165	24/26 (92%)
		TM helix 7	497..522	CDD:320165	20/24 (83%)
		Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250	526..531		4/4 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	560..581		14/20 (70%)
		PDZ-binding	579..581		0/1 (0%)
Fzd10	NP_780493.1	CRD_FZ	31..157	CDD:295308	119/125 (95%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	153..189		33/35 (94%)
		Frizzled	219..536	CDD:279827	298/316 (94%)
		Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250	527..532		4/4 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	561..582		14/20 (70%)
		PDZ-binding	580..582		0/1 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83965768
Domainoid	1	1.000	633	1.000	Domainoid score	I4668
eggNOG	1	0.900	-	-		E1_KOG3577
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H21411
Inparanoid	1	1.050	1147	1.000	Inparanoid score	I4707
Isobase	0	0.000	Not matched by this tool.
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG50792
OrthoDB	1	1.010	-	-		D102253at32523
OrthoFinder	1	1.000	-	-		FOG0013181
OrthoInspector	1	1.000	-	-		oto127034
orthoMCL	1	0.900	-	-		OOG6_108212
Panther	1	1.100	-	-	LDO	PTHR11309
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R10868
SonicParanoid	1	1.000	-	-		X126
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	18	18.300