Protein Alignment FZD10 and fz2

DIOPT Version :10

• Sequence 1: NP_009128.1
• Gene: FZD10 / 11211
• HGNCID: 4039
• Length: 581
• Species: Homo sapiens
• Sequence 2: NP_001401042.1
• Gene: fz2 / 40090
• FlyBaseID: FBgn0016797
• Length: 826
• Species: Drosophila melanogaster
• Alignment Length: 653
• Identity: 271/653 - (41%)
• Similarity: 350/653 - (53%)
• Gaps: 153/653 - (23%)

Human     8 LWLVLQVMGSCAA----------ISSMDM--------ERPGDG----------KCQPIEIPMCKD 44
            |.||| ::.||.|          :..|.|        ..||.|          :|:.|.||||:.
  Fly    11 LGLVL-LLTSCRADGPLHSADHGMGGMGMGGHGLDASPAPGYGVPVIPKDPNLRCEEITIPMCRG 74

Human    45 IGYNMTRMPNLMGHENQREAAIQLHEFAPLVEYGCHGHLRFFLCSLYAPMCTEQVSTPIPACRVM 109
            ||||||..||.|.||.|.||.:::|:|.||||..|...|:|||||:|.|:|.|....|:|.||.:
  Fly    75 IGYNMTSFPNEMNHETQDEAGLEVHQFWPLVEIKCSPDLKFFLCSMYTPICLEDYHKPLPVCRSV 139

Human   110 CEQARLKCSPIMEQFNFKWPDSLDCRKLPNKNDPNYLCMEAP------NNGSDEPTRGSGLFPPL 168
            ||:||..|:|||:|::|:||:.:.|..||...||:.||||.|      :.||...:.|||
  Fly   140 CERARSGCAPIMQQYSFEWPERMACEHLPLHGDPDNLCMEQPSYTEAGSGGSSGGSGGSG----- 199

Human   169 FRPQRPHSAQEHPLKDGGPGRGG----------------------CDNP---------------- 195
                 ..|......|.||.|.||                      |.||
  Fly   200 -----SGSGSGGKRKQGGSGSGGSGAGGSSGSTSTKPCRGRNSKNCQNPQGEKASGKECSCSCRS 259

Human   196 -----GK------------FHH---------VEKSASCAPLC-TPGVDVYWSREDKRFAVVWLAI 233
                 ||            .||         |::.|. .|.| .|....::|.::|.||.:|:|:
  Fly   260 PLIFLGKEQLLQQQSQMPMMHHPHHWYMNLTVQRIAG-VPNCGIPCKGPFFSNDEKDFAGLWIAL 323

Human   234 WAVLCFFSSAFTVLTFLIDPARFRYPERPIIFLSMCYCVYSVGYLIRLFAGAESIACD----RDS 294
            |:.|||.|:..|:.||:||..||:||||||:|||.||.:.:||||.|.|...|.||||    |:|
  Fly   324 WSGLCFCSTLMTLTTFIIDTERFKYPERPIVFLSACYFMVAVGYLSRNFLQNEEIACDGLLLRES 388

Human   295 GQLYVIQEGLESTG---CTLVFLVLYYFGMASSLWWVVLTLTWFLAAGKKWGHEAIEANSSYFHL 356
                       |||   ||||||:.|:||||||:|||:|:.|||||||.|||:|||..:|.||||
  Fly   389 -----------STGPHSCTLVFLLTYFFGMASSIWWVILSFTWFLAAGLKWGNEAITKHSQYFHL 442

Human   357 AAWAIPAVKTILILVMRRVAGDELTGVCYVGSMDVNALTGFVLIPLACYLVIGTSFILSGFVALF 421
            |||.||.|:::.:|::..|.||.:.|:||||:::.:.|..|||.||..||||||:|:::|||:||
  Fly   443 AAWLIPTVQSVAVLLLSAVDGDPILGICYVGNLNPDHLKTFVLAPLFVYLVIGTTFLMAGFVSLF 507

Human   422 HIRRVMKT-----GGENTDKLEKLMVRIGLFSVLYTVPATCVIACYFYERLNMDYWKILAAQHKC 481
            .||.|:|.     .|...|||||||:|||:||||||||||.||.||.||....:.|
  Fly   508 RIRSVIKQQGGVGAGVKADKLEKLMIRIGIFSVLYTVPATIVIGCYLYEAAYFEDW--------- 563

Human   482 KMNNQTKTLDCLMA-----ASIPAVEIFMVKIFMLLVVGITSGMWIWTSKTLQSWQQVCSRRLKK 541
                 .|.|.|..|     ...|...:.|:|.||.|.||||||:|||:.|||:||::...|.|..
  Fly   564 -----IKALACPCAQVKGPGKKPLYSVLMLKYFMALAVGITSGVWIWSGKTLESWRRFWRRLLGA 623

Human   542 KSR 544
            ..|
  Fly   624 PDR 626

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FZD10	NP_009128.1	CRD_FZ10	30..156	CDD:143571	66/141 (47%)
		7tmF_FZD10	217..535	CDD:320165	169/334 (51%)
		TM helix 1	226..251	CDD:320165	12/24 (50%)
		TM helix 2	260..281	CDD:320165	13/20 (65%)
		TM helix 3	310..336	CDD:320165	18/25 (72%)
		TM helix 4	353..369	CDD:320165	10/15 (67%)
		TM helix 5	391..420	CDD:320165	16/28 (57%)
		TM helix 6	440..467	CDD:320165	21/26 (81%)
		TM helix 7	497..522	CDD:320165	12/24 (50%)
		Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family members. /evidence=ECO:0000250	526..531		3/4 (75%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	560..581
		PDZ-binding	579..581
fz2	NP_001401042.1	CRD_FZ5_like	63..182	CDD:143565	62/118 (53%)
		7tmF_FZD5_FZD8-like	307..618	CDD:320163	169/335 (50%)
		TM helix 1	316..341	CDD:320163	12/24 (50%)
		TM helix 2	350..371	CDD:320163	13/20 (65%)
		TM helix 3	396..422	CDD:320163	18/25 (72%)
		TM helix 4	439..455	CDD:320163	10/15 (67%)
		TM helix 5	477..506	CDD:320163	16/28 (57%)
		TM helix 6	531..558	CDD:320163	21/26 (81%)
		TM helix 7	579..604	CDD:320163	12/24 (50%)