Protein Alignment CHM and MRS6

DIOPT Version :10

• Sequence 1: NP_000381.1
• Gene: CHM / 1121
• HGNCID: 1940
• Length: 653
• Species: Homo sapiens
• Sequence 2: NP_015015.1
• Gene: MRS6 / 854552
• SGDID: S000005897
• Length: 603
• Species: Saccharomyces cerevisiae
• Alignment Length: 722
• Identity: 150/722 - (20%)
• Similarity: 258/722 - (35%)
• Gaps: 239/722 - (33%)

Human     4 TLPSEFDVIVIGTGLPESIIAAACSRSGRRVLHVDSRSYYGGNWASFSFSGLLSWLKEYQENSDI 68
            |.|.:.||::.|||:.||::|||.:..|..|||:|...|||...|:.:...:..|:.|..|.|
Yeast    42 TTPDKVDVLIAGTGMVESVLAAALAWQGSNVLHIDKNDYYGDTSATLTVDQIKRWVNEVNEGS-- 104

Human    69 VSDSPVWQDQILENEEAIALSRKDKTIQHVEVFCYASQDLHEDVEEAGALQKNHALVTSANSTEA 133
                                           |.||                ||..|..|
Yeast   105 -------------------------------VSCY----------------KNAKLYVS------ 116

Human   134 ADSAFLPTEDESLSTMSCEMLTEQTPSSDPENALEVNGAEVTGEKENHCDDKTCVPSTSAEDMSE 198
                                                                |.:.|..
Yeast   117 ----------------------------------------------------TLIGSGK------ 123

Human   199 NVPIAEDTTEQPKKNRITYSQIIKEGRRFNIDLVSKLLYSRGLLIDLLIKSNVSRYAEFKNITRI 263
                              ||     .|.|.|||..|:|:::..|:.:||||.|.:|.||::::..
Yeast   124 ------------------YS-----SRDFGIDLSPKILFAKSDLLSILIKSRVHQYLEFQSLSNF 165

Human   264 LAFREGRVEQVPCSRADVFNSKQLTMVEKRMLMKFLTFCMEYEKYPDEYKGYEEITFYEYLKTQ- 327
            ..:.....|::..::.::|..:.|.::.||.||||:.|.:.:|...:.::.|.|.|..::|..:
Yeast   166 HTYENDCFEKLTNTKQEIFTDQNLPLMTKRNLMKFIKFVLNWEAQTEIWQPYAERTMSDFLGEKF 230

Human   328 KLTPNLQYIVMHSIAMTSETASSTIDGLKATKNFLHCLGRYGNTPFLFPLY-GQGELPQCFCRMC 391
            ||.....:.::.||.:..:......:.|:..:.:|.....||..|.|...| |.|||.|.|||..
Yeast   231 KLEKPQVFELIFSIGLCYDLNVKVPEALQRIRRYLTSFDVYGPFPALCSKYGGPGELSQGFCRSA 295

Human   392 AVFGGIYCLRHSVQCLVVDKESRKCKAIIDQFGQRI-ISEHFLVEDSYFPENM--CSRVQYRQIS 453
            ||.|..|.|...   ||....:.|.....|  |.:: :||..::..:..|::.  ..:.|| |:.
Yeast   296 AVGGATYKLNEK---LVSFNPTTKVATFQD--GSKVEVSEKVIISPTQAPKDSKHVPQQQY-QVH 354

Human   454 RAVLITDRSVLKTDSDQQISILTV-PAEEPGTF------AVRVIELCSSTMTCMKGTYLVHLTCT 511
            |...|.:....:..::.:.:.:.| |   ||:.      .|:...|.:.:..|.:||.:.:|:.|
Yeast   355 RLTCIVENPCTEWFNEGESAAMVVFP---PGSLKSGNKEVVQAFILGAGSEICPEGTIVWYLSTT 416

Human   512 -----------------------SSKTAREDLESVVQ------------------KLFVPYTEME 535
                                   .|.:..|:.|.:||                  |.:||.
Yeast   417 EQGPRAEMDIDAALEAMEMALLRESSSGLENDEEIVQLTGNGHTIVNSVKLGQSFKEYVPR---- 477

Human   536 IENEQVEKPRILWALYFNMRDSS---DISRSCYNDLPSNV---YVCSGPDCG----------LGN 584
                  |:.:.|:.||:....|:   .:..|.:.|:..::   |:....|.|          :..
Yeast   478 ------ERLQFLFKLYYTQYTSTPPFGVVNSSFFDVNQDLEKKYIPGASDNGVIYTTMPSAEISY 536

Human   585 DNAVKQAETLFQEICPNEDFCPPPPNPEDIILDGDSLQPEASESSAIPEANSETFKESTNLG--- 646
            |..|..|:.|:::|.          ..:|...|.|....:..::|.:  ||:|.|:.:.:..
Yeast   537 DEVVTAAKVLYEKIV----------GSDDDFFDLDFEDEDEIQASGV--ANAEQFENAIDDDDDV 589

Human   647 NLEESSE 653
            |:|.|.|
Yeast   590 NMEGSGE 596

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CHM	NP_000381.1	NAD_binding_8	13..>54	CDD:433218	17/40 (43%)
		Rossmann-fold NAD(P)(+)-binding proteins	225..542	CDD:473865	87/369 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	606..653		11/49 (22%)
MRS6	NP_015015.1	MRS6	44..510	CDD:227377	129/620 (21%)