Protein Alignment CHM and chm

DIOPT Version :10

• Sequence 1: NP_000381.1
• Gene: CHM / 1121
• HGNCID: 1940
• Length: 653
• Species: Homo sapiens
• Sequence 2: NP_982286.2
• Gene: chm / 402935
• ZFINID: ZDB-GENE-030318-2
• Length: 666
• Species: Danio rerio
• Alignment Length: 665
• Identity: 368/665 - (55%)
• Similarity: 471/665 - (70%)
• Gaps: 35/665 - (5%)

Human     2 ADTLPSEFDVIVIGTGLPESIIAAACSRSGRRVLHVDSRSYYGGNWASFSFSGLLSWLKEY--QE 64
            |:.|||:|||:::||||.||:|||||||.|:.|||:|.|:||.||||||:|:|||||::||  |:
Zfish     3 AEDLPSQFDVVILGTGLTESVIAAACSRVGQSVLHLDRRNYYAGNWASFTFNGLLSWIEEYKNQQ 67

Human    65 NSDIVSDSPVWQDQILENEEAIALSRKDKTIQHVEVFCYASQDLHEDVEEAGALQKNHALV---- 125
            ...|......|:..|.:.|||:.|:..|.:|.::|||||||::..::.|....|...:|..
Zfish    68 ELQITESEQEWRSLIEDGEEAVPLNSVDSSISNLEVFCYASEEEEQEEETKDLLTCPNAETVSEE 132

Human   126 TSANSTEAADSAFLPTEDESLSTMSCEMLTEQTPSSDPENALEVNGAEVTGEKENHCDDKTCVPS 190
            |:::|||..|:.   |.|: ::..:.::..|:...|.|:..|             |..| ....|
Zfish   133 TNSDSTETQDTV---TSDD-VTESNVKVQNEENEDSAPKEQL-------------HASD-ISEHS 179

Human   191 TSAEDMSENVPIAEDTTEQPKKNRITYSQIIKEGRRFNIDLVSKLLYSRGLLIDLLIKSNVSRYA 255
            .|.|:...|...|:...|..||  |||.:::||||||||||||||:||||.|:||||||||||||
Zfish   180 QSVEEKQPNRSPADPPAELQKK--ITYQKLLKEGRRFNIDLVSKLMYSRGALVDLLIKSNVSRYA 242

Human   256 EFKNITRILAFREGRVEQVPCSRADVFNSKQLTMVEKRMLMKFLTFCMEYEKYPDEYKGYEEITF 320
            |||||.|||..|.|:||||||||||||.|||||:|||||||||||||:::|::|:||:.|.|..|
Zfish   243 EFKNIGRILTCRNGKVEQVPCSRADVFASKQLTVVEKRMLMKFLTFCLDFEQHPEEYQDYSEKPF 307

Human   321 YEYLKTQKLTPNLQYIVMHSIAMTSETASSTIDGLKATKNFLHCLGRYGNTPFLFPLYGQGELPQ 385
            .|:||.:|||.|||..|:.||||.:: .:.|.:|||||::||.||||||||||||||||.||:||
Zfish   308 SEFLKNKKLTENLQDFVLLSIAMVTQ-QTLTEEGLKATQHFLRCLGRYGNTPFLFPLYGLGEIPQ 371

Human   386 CFCRMCAVFGGIYCLRHSVQCLVVDKESRKCKAIIDQFGQRIISEHFLVEDSYFPENMCSRVQYR 450
            ||||||||||||||||||||||||||||.|.||:||..||:|...||:|||||..|.....:.||
Zfish   372 CFCRMCAVFGGIYCLRHSVQCLVVDKESNKVKAVIDTRGQKIGCSHFVVEDSYIREEQRESINYR 436

Human   451 QISRAVLITDRSVLKTDSDQQISILTVPAEEPGTFAVRVIELCSSTMTCMKGTYLVHLTCTSSKT 515
            ||||||||||||||.::||||||::|||..|....|||::|||||:||||.||.||||||:||.|
Zfish   437 QISRAVLITDRSVLPSESDQQISLVTVPPVESSGPAVRMVELCSSSMTCMPGTCLVHLTCSSSGT 501

Human   516 AREDLESVVQKLF-VPYTEMEIENE---QVEKPRILWALYFNMRDSSDISRSCYNDLPSNVYVCS 576
            |::||..||.:|| :|.|..|..:|   ::.||.:||.:||||||:|.:..|||: |||||:||:
Zfish   502 AQQDLAPVVSQLFHIPTTPGEDPSEGTGEISKPAVLWVMYFNMRDTSAMDSSCYS-LPSNVHVCT 565

Human   577 GPDCGLGNDNAVKQAETLFQEICPNEDFCPPPPNPEDIILDGDSLQPEA---SESSAIPEANSET 638
            |||.|||:|.::|.||::|..:.|:|:||||.|||||||.|||:.|.|.   .||:......|:.
Zfish   566 GPDAGLGSDYSIKLAESVFHCLLPDEEFCPPAPNPEDIIYDGDAPQAEGRGFDESNDTEADKSQA 630

Human   639 FKESTNLGNLEESSE 653
            .:|.|......|:||
Zfish   631 EEEGTTNETNPENSE 645

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CHM	NP_000381.1	NAD_binding_8	13..>54	CDD:433218	28/40 (70%)
		Rossmann-fold NAD(P)(+)-binding proteins	225..542	CDD:473865	221/320 (69%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	606..653		20/49 (41%)
chm	NP_982286.2	None