Protein Alignment CHM and Rep

DIOPT Version :10

• Sequence 1: NP_000381.1
• Gene: CHM / 1121
• HGNCID: 1940
• Length: 653
• Species: Homo sapiens
• Sequence 2: NP_477420.1
• Gene: Rep / 37246
• FlyBaseID: FBgn0026378
• Length: 511
• Species: Drosophila melanogaster
• Alignment Length: 660
• Identity: 199/660 - (30%)
• Similarity: 310/660 - (46%)
• Gaps: 159/660 - (24%)

Human     1 MADTLPSEFDVIVIGTGLPESIIAAACSRSGRRVLHVDSRSYYGGNWASFSFSGLLSWLKEYQEN 65
            |.|.||.:||::|||||..||.||||.||.|:.|||:||..|||..|:|||...|.:.|
  Fly     1 MLDDLPEQFDLVVIGTGFTESCIAAAGSRIGKSVLHLDSNEYYGDVWSSFSMDALCARL------ 59

Human    66 SDIVSDSPVWQDQILENEEAIALSRKDKTIQHVEVFCYASQDLHEDVEEAGALQKNHALVTSANS 130
                       ||.:|...|:..:|            |....:
  Fly    60 -----------DQEVEPHSALRNAR------------YTWHSM---------------------- 79

Human   131 TEAADSAFLPTEDESLSTMSCEMLTEQTPSSDPENALEVNGAEVTGEKENHCDDKTCVPSTSAED 195
                                                          |||:..|.::.
  Fly    80 ----------------------------------------------EKESETDAQSW-------- 90

Human   196 MSENVPIAEDTTEQPKKNRITYSQIIKEGRRFNIDLVSKLLYSRGLLIDLLIKSNVSRYAEFKNI 260
                             ||   ..::.:.|||::||..::||:.|.|:.||||||:.|||||:.:
  Fly    91 -----------------NR---DSVLAKSRRFSLDLCPRILYAAGELVQLLIKSNICRYAEFRAV 135

Human   261 TRILAFREGRVEQVPCSRADVFNSKQLTMVEKRMLMKFLTFCMEY--EKYPDEYKGYEEITFYEY 323
            ..:.....|.:..|||||:||||:|.||:||||:||||||.|.:|  :|..::...:...||.||
  Fly   136 DHVCMRHNGEIVSVPCSRSDVFNTKTLTIVEKRLLMKFLTACNDYGEDKCNEDSLEFRGRTFLEY 200

Human   324 LKTQKLTPNLQYIVMHSIAMTSETASSTIDGLKATKNFLHCLGRYGNTPFLFPLYGQGELPQCFC 388
            |:.|::|..:...||.:|||...:.|.. :|::.|:.||..||||||||||||:||.||||||||
  Fly   201 LQAQRVTEKISSCVMQAIAMCGPSTSFE-EGMQRTQRFLGSLGRYGNTPFLFPMYGCGELPQCFC 264

Human   389 RMCAVFGGIYCLRHSVQCLVVDKESRKCKAIIDQFGQRIISEHFLVEDSYFPENMCSRVQYR-QI 452
            |:|||:||||||:.:|..:.:|..|.  :.::...|:.:.:::.:....|.|  :...::.: .|
  Fly   265 RLCAVYGGIYCLKRAVDDIALDSNSN--EFLLSSAGKTLRAKNVVSAPGYTP--VSKGIELKPHI 325

Human   453 SRAVLITDRSVLKTDSDQ---QISILTVPAEEPGTFAVRVIELCSSTMTCMKGTYLVHLTCTS-S 513
            ||.:.|:...:...:.::   .:::|.:...|.|..|. :|:|...|..|.:|.|:.|||..: |
  Fly   326 SRGLFISSSPLGNEELNKGGGGVNLLRLLDNEGGREAF-LIQLSHYTGACPEGLYIFHLTTPALS 389

Human   514 KTAREDLESVVQKLFVPYTEMEIENEQVEKPRILWALYFNMRDSSDISRSCYNDLPSNVYVCSGP 578
            :....||.....:||          :|.: .:|:::.||.:...|..|.:.     .::|....|
  Fly   390 EDPASDLAIFTSQLF----------DQSD-AQIIFSSYFTIAAQSSKSPAA-----EHIYYTDPP 438

Human   579 DCGLGNDNAVKQAETLFQEICPNEDFCPPPPNPEDIILDGDSLQPEASESSAIPE---ANSETFK 640
            ...|..|.|:..|..:|.::.|:.||.|..|:||:|::||:  .|.|.....:||   |.....:
  Fly   439 TYELDYDAAIANARDIFGKMFPDADFLPRAPDPEEIVVDGE--DPSALNEHTLPEDLRAQLHDMQ 501

Human   641 ESTNLGNLEE 650
            ::|...:::|
  Fly   502 QATQEMDIQE 511

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CHM	NP_000381.1	NAD_binding_8	13..>54	CDD:433218	26/40 (65%)
		Rossmann-fold NAD(P)(+)-binding proteins	225..542	CDD:473865	124/323 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	606..653		14/48 (29%)
Rep	NP_477420.1	Rossmann-fold NAD(P)(+)-binding proteins	4..397	CDD:473865	164/523 (31%)