DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CHM and mrs6

DIOPT Version :10

Sequence 1:NP_000381.1 Gene:CHM / 1121 HGNCID:1940 Length:653 Species:Homo sapiens
Sequence 2:NP_595923.1 Gene:mrs6 / 2539612 PomBaseID:SPBC15C4.03 Length:459 Species:Schizosaccharomyces pombe


Alignment Length:630 Identity:127/630 - (20%)
Similarity:224/630 - (35%) Gaps:215/630 - (34%)


- Green bases have known domain annotations that are detailed below.


Human     6 PSEFDVIVIGTGLPESIIAAACSRSGRRVLHVDSRSYYGGNWASFSFSGLLSWLKEYQENSDIVS 70
            |:.:|||::||.|..||::||.|.:.:||||:|..|:||                          
pombe     4 PNSYDVIIVGTNLRNSILSAALSWANQRVLHIDENSFYG-------------------------- 42

Human    71 DSPVWQDQILENEEAIALSRKDKTIQHVEVFCYASQDLHEDVEEAGALQKNHALVTSANSTEAAD 135
                                        |:                                   
pombe    43 ----------------------------EI----------------------------------- 44

Human   136 SAFLPTEDESLSTMSCEMLTEQTPSSDPENALEVNGAEVTGEKENHCDDKTCVPSTSAEDMSENV 200
                   |.||:....|.:.|:....|....|..||                         |...
pombe    45 -------DGSLTLRDLEQINEKIKKVDSSQILNDNG-------------------------SHKS 77

Human   201 PIAEDTTEQPKKNRITY--SQIIKEGRRFNIDLVSKLLYSRGLLIDLLIKSNVSRYAEFK--NIT 261
            |:        |:..:.:  ..:|.:.:...|....:.:::...|:.||.::.:.:|...|  ...
pombe    78 PL--------KRFEVQFLNKDLIPKNKGSVIQFHPQEIFASSELVKLLSETKIYKYLLLKPARSF 134

Human   262 RILAFREGRVEQVPCSRADVFNSKQLTMVEKRMLMKFLTFCMEY--EKYPDEYKGYEEITFYEYL 324
            |:|...|..: :||.||||:||:|.|::..||::|:|:.|....  |:..:..|.:|...||::|
pombe   135 RLLTSNEEWI-KVPESRADIFNNKNLSLASKRIVMRFMKFVSNIADEQNQNLVKEWESKPFYKFL 198

Human   325 -KTQKLTPNLQYIVMHSIAMTSETASSTIDGLKATKNFLHCLGRYGNTPFLFPLYGQG-ELPQCF 387
             :..:|:..::..:::.:..:......|.|.|.....:.|..|.||:..:|..:||.| ||.|.|
pombe   199 EEVFQLSGAIEESIIYGLCQSLSKDIPTKDALDTVLKYFHSFGMYGDYSYLLAMYGTGSELCQGF 263

Human   388 CRMCAVFGGIYCLRHSV----QCLVVDKESRKCKAIIDQFGQRIISEHFLVEDSYFPENMCSRVQ 448
            ||..||.||.:.|..::    :..:|.|:.....|      ::|:|.   |::...|        
pombe   264 CRSSAVMGGTFMLGQAIDKIDESKIVLKDGSTLSA------KKIVSS---VDEGKLP-------- 311

Human   449 YRQISRAVLITDRSVLKTDSDQQISILTVPAEEPGTFAVRVIELC-------------------- 493
            ::||.:..|:     :|.|..|..       :|.|.||.....|.                    
pombe   312 HQQIQQRYLL-----VKGDCQQLF-------QEDGFFAALDASLIHFSPFSISENFGNSVQAKLY 364

Human   494 -SSTMTCMKGTYLVHLTCTSSKTAREDLESVVQKL--FVPYTEMEI---ENEQVEKPRILWALYF 552
             |.:..|.:|..:.:|...:.....|......:||  |....::||   .:|.:.:.|     :.
pombe   365 GSGSGDCPEGYCIWYLKTLNDSPCNEVFNLATKKLCSFSGCDDLEIIVQVDETLNQLR-----HI 424

Human   553 NMRDSSDISRSCYNDLPSNVYVCSGPDCGLGNDNAVKQAETLFQE 597
            :..|:...::|.:.::             ||.:|...|.|.||.|
pombe   425 DYDDTLHSAKSLFYEI-------------LGQNNTFLQREGLFDE 456

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CHMNP_000381.1 NAD_binding_8 13..>54 CDD:433218 16/40 (40%)
Rossmann-fold NAD(P)(+)-binding proteins 225..542 CDD:473865 82/352 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 606..653
mrs6NP_595923.1 MRS6 1..459 CDD:227377 127/630 (20%)
Blue background indicates that the domain is not in the aligned region.

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