Protein Alignment CHM and Chm

DIOPT Version :10

• Sequence 1: NP_000381.1
• Gene: CHM / 1121
• HGNCID: 1940
• Length: 653
• Species: Homo sapiens
• Sequence 2: NP_058763.2
• Gene: Chm / 24942
• RGDID: 2340
• Length: 650
• Species: Rattus norvegicus
• Alignment Length: 656
• Identity: 548/656 - (83%)
• Similarity: 585/656 - (89%)
• Gaps: 9/656 - (1%)

Human     1 MADTLPSEFDVIVIGTGLPESIIAAACSRSGRRVLHVDSRSYYGGNWASFSFSGLLSWLKEYQEN 65
            |||.|||:|||||||||||||||||||||||:|||||||||||||||||||||||||||||||||
  Rat     1 MADNLPSDFDVIVIGTGLPESIIAAACSRSGQRVLHVDSRSYYGGNWASFSFSGLLSWLKEYQEN 65

Human    66 SDIVSDSPVWQDQILENEEAIALSRKDKTIQHVEVFCYASQDLHEDVEEAGALQKNHALVTSANS 130
            :|:|:::.:||:|||||||||.||.|||||||||||||||||||:|||||||||||||.||||.|
  Rat    66 NDVVTENSMWQEQILENEEAIPLSSKDKTIQHVEVFCYASQDLHKDVEEAGALQKNHASVTSAQS 130

Human   131 TEAADSA---FLPTEDESLSTMSCEMLTEQTPSSDPENALEVNGAEVTGEKENHCDDKTCVPSTS 192
            .|||::|   .|||..|.||..|||:..||:....||::.|||.||.||:||| .|.|     :|
  Rat   131 AEAAEAAETSCLPTAVEPLSMGSCEIPAEQSQCPGPESSPEVNDAEATGKKEN-SDAK-----SS 189

Human   193 AEDMSENVPIAEDTTEQPKKNRITYSQIIKEGRRFNIDLVSKLLYSRGLLIDLLIKSNVSRYAEF 257
            .|:.|||||..:|.||.||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   190 TEEPSENVPKVQDNTETPKKNRITYSQIIKEGRRFNIDLVSKLLYSRGLLIDLLIKSNVSRYAEF 254

Human   258 KNITRILAFREGRVEQVPCSRADVFNSKQLTMVEKRMLMKFLTFCMEYEKYPDEYKGYEEITFYE 322
            ||||||||||||.||||||||||||||||||||||||||||||||:|||::||||:.||..||.|
  Rat   255 KNITRILAFREGTVEQVPCSRADVFNSKQLTMVEKRMLMKFLTFCVEYEEHPDEYRAYEGTTFSE 319

Human   323 YLKTQKLTPNLQYIVMHSIAMTSETASSTIDGLKATKNFLHCLGRYGNTPFLFPLYGQGELPQCF 387
            |||||||||||||.|:|||||||||.|.|:|||||||.||.||||||||||||||||||||||||
  Rat   320 YLKTQKLTPNLQYFVLHSIAMTSETTSCTVDGLKATKKFLQCLGRYGNTPFLFPLYGQGELPQCF 384

Human   388 CRMCAVFGGIYCLRHSVQCLVVDKESRKCKAIIDQFGQRIISEHFLVEDSYFPENMCSRVQYRQI 452
            |||||||||||||||||||||||||||||||:||||||||||:||::||||..||.|||||||||
  Rat   385 CRMCAVFGGIYCLRHSVQCLVVDKESRKCKAVIDQFGQRIISKHFIIEDSYLSENTCSRVQYRQI 449

Human   453 SRAVLITDRSVLKTDSDQQISILTVPAEEPGTFAVRVIELCSSTMTCMKGTYLVHLTCTSSKTAR 517
            ||||||||.||||||:|||:|||||||||||:||||||||||||||||||||||||||.||||||
  Rat   450 SRAVLITDGSVLKTDADQQVSILTVPAEEPGSFAVRVIELCSSTMTCMKGTYLVHLTCMSSKTAR 514

Human   518 EDLESVVQKLFVPYTEMEIENEQVEKPRILWALYFNMRDSSDISRSCYNDLPSNVYVCSGPDCGL 582
            ||||.||||||.||||:|.|||||||||:||||||||||||||||.||||||||||||||||.||
  Rat   515 EDLERVVQKLFTPYTEIEAENEQVEKPRLLWALYFNMRDSSDISRDCYNDLPSNVYVCSGPDSGL 579

Human   583 GNDNAVKQAETLFQEICPNEDFCPPPPNPEDIILDGDSLQPEASESSAIPEANSETFKESTNLGN 647
            ||||||||||||||:|||||||||.|||||||:|||||.|.|..|||..||.||||.||||.|||
  Rat   580 GNDNAVKQAETLFQQICPNEDFCPAPPNPEDIVLDGDSSQQEVPESSVTPETNSETPKESTVLGN 644

Human   648 LEESSE 653
            .||.||
  Rat   645 PEEPSE 650

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CHM	NP_000381.1	NAD_binding_8	13..>54	CDD:433218	39/40 (98%)
		Rossmann-fold NAD(P)(+)-binding proteins	225..542	CDD:473865	284/316 (90%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	606..653		33/46 (72%)
Chm	NP_058763.2	Rossmann-fold NAD(P)(+)-binding proteins	6..530	CDD:473865	441/529 (83%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	156..208		26/57 (46%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	603..650		33/46 (72%)