Protein Alignment CHM and Chm

DIOPT Version :10

• Sequence 1: NP_000381.1
• Gene: CHM / 1121
• HGNCID: 1940
• Length: 653
• Species: Homo sapiens
• Sequence 2: NP_001396596.1
• Gene: Chm / 12662
• MGIID: 892979
• Length: 674
• Species: Mus musculus
• Alignment Length: 655
• Identity: 532/655 - (81%)
• Similarity: 571/655 - (87%)
• Gaps: 21/655 - (3%)

Human    14 IGTGLPESIIAAACSRSGRRVLHVDSRSYYGGNWASFSFSGLLSWLKEYQENSDIVSDSPVWQDQ 78
            :.:|||||||||||||||:|||||||||||||||||||||||||||||||||||:|:::.:||:|
Mouse    26 VSSGLPESIIAAACSRSGQRVLHVDSRSYYGGNWASFSFSGLLSWLKEYQENSDVVTENSMWQEQ 90

Human    79 ILENEEAIALSRKDKTIQHVEVFCYASQDLHEDVEEAGALQKNHALVTS---------------A 128
            ||||||||.||.|||||||||||||||||||:|||||||||||.|.|.|               |
Mouse    91 ILENEEAILLSSKDKTIQHVEVFCYASQDLHKDVEEAGALQKNPASVMSAQATEAAEAAEAAEAA 155

Human   129 NSTEAADSAFLPTEDESLSTMSCEMLTEQTPSSDPENALEVNGAEVTGEKENHCDDKTCVPSTSA 193
            .:||||::|.|||.:|||||.|||:..||:..:.||::.:||.||| ||||...|.|     :|.
Mouse   156 EATEAAEAACLPTAEESLSTRSCELPAEQSQCTGPESSPQVNDAEV-GEKETQSDAK-----SST 214

Human   194 EDMSENVPIAEDTTEQPKKNRITYSQIIKEGRRFNIDLVSKLLYSRGLLIDLLIKSNVSRYAEFK 258
            |..||.:|..:|.||.||:|.||||||||||||||||||||||||||||||||||||||||||||
Mouse   215 EQSSEILPKVQDNTETPKRNVITYSQIIKEGRRFNIDLVSKLLYSRGLLIDLLIKSNVSRYAEFK 279

Human   259 NITRILAFREGRVEQVPCSRADVFNSKQLTMVEKRMLMKFLTFCMEYEKYPDEYKGYEEITFYEY 323
            |||||||||||.||||||||||||||||||||||||||||||||:|||.:|||||.|||.||.||
Mouse   280 NITRILAFREGTVEQVPCSRADVFNSKQLTMVEKRMLMKFLTFCVEYEDHPDEYKAYEETTFSEY 344

Human   324 LKTQKLTPNLQYIVMHSIAMTSETASSTIDGLKATKNFLHCLGRYGNTPFLFPLYGQGELPQCFC 388
            ||||||||||||.|:|||||||||.|||:|||||||.||.|||||||||||||||||||||||||
Mouse   345 LKTQKLTPNLQYFVLHSIAMTSETTSSTVDGLKATKKFLQCLGRYGNTPFLFPLYGQGELPQCFC 409

Human   389 RMCAVFGGIYCLRHSVQCLVVDKESRKCKAIIDQFGQRIISEHFLVEDSYFPENMCSRVQYRQIS 453
            |||||||||||||||||||||||||||||||:|||||||||:||::||||..||.||.|||||||
Mouse   410 RMCAVFGGIYCLRHSVQCLVVDKESRKCKAIVDQFGQRIISKHFVIEDSYLSENTCSGVQYRQIS 474

Human   454 RAVLITDRSVLKTDSDQQISILTVPAEEPGTFAVRVIELCSSTMTCMKGTYLVHLTCTSSKTARE 518
            |||||||.||||.|||||:|||||||||.|:||||||||||||||||||||||||||.|||||||
Mouse   475 RAVLITDGSVLKPDSDQQVSILTVPAEESGSFAVRVIELCSSTMTCMKGTYLVHLTCMSSKTARE 539

Human   519 DLESVVQKLFVPYTEMEIENEQVEKPRILWALYFNMRDSSDISRSCYNDLPSNVYVCSGPDCGLG 583
            |||.||||||.||||:|.||||||||||||||||||||||||||.|||||||||||||||||.||
Mouse   540 DLERVVQKLFTPYTEIEAENEQVEKPRILWALYFNMRDSSDISRDCYNDLPSNVYVCSGPDCNLG 604

Human   584 NDNAVKQAETLFQEICPNEDFCPPPPNPEDIILDGDSLQPEASESSAIPEANSETFKESTNLGNL 648
            |||||:||||:||:|||||||||.|||||||||||||.|.|.||||.|||.||||.||||.||:.
Mouse   605 NDNAVQQAETVFQKICPNEDFCPAPPNPEDIILDGDSSQQEVSESSVIPETNSETPKESTVLGDS 669

Human   649 EESSE 653
            ||.||
Mouse   670 EEPSE 674

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CHM	NP_000381.1	NAD_binding_8	13..>54	CDD:433218	35/39 (90%)
		Rossmann-fold NAD(P)(+)-binding proteins	225..542	CDD:473865	285/316 (90%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	606..653		35/46 (76%)
Chm	NP_001396596.1	Rossmann-fold NAD(P)(+)-binding proteins	246..554	CDD:473865	278/307 (91%)