Protein Alignment CHM and chm

DIOPT Version :10

• Sequence 1: NP_000381.1
• Gene: CHM / 1121
• HGNCID: 1940
• Length: 653
• Species: Homo sapiens
• Sequence 2: XP_002938593.1
• Gene: chm / 100488898
• XenbaseID: XB-GENE-956389
• Length: 641
• Species: Xenopus tropicalis
• Alignment Length: 656
• Identity: 369/656 - (56%)
• Similarity: 478/656 - (72%)
• Gaps: 23/656 - (3%)

Human     1 MADTLPSEFDVIVIGTGLPESIIAAACSRSGRRVLHVDSRSYYGGNWASFSFSGLLSWLKEYQE- 64
            |||.||:||||:::|||||||||||||:|.|:||||:|:|:|||||||||:||||.:|::..::
 Frog     1 MADDLPTEFDVVILGTGLPESIIAAACTRIGQRVLHIDARNYYGGNWASFTFSGLQTWIENCKQE 65

Human    65 -NSDIVSDSPVWQDQILENEEAIALSRKDKTIQHVEVFCYASQDLHEDVEEAGALQKNHALVTSA 128
             |:::.:   ..:.|.|:|||.|..:::::|||::|||||:|.:..|.|||||||..|.||:|:.
 Frog    66 LNTELAA---ACKGQALDNEEIIPFNKRNQTIQNIEVFCYSSTEDGEAVEEAGALNINSALLTTV 127

Human   129 NSTEAADSAFLPTEDESLSTMSCEMLTEQTPSSDPENALEVNGAEVTGEKENHCDDKTCVPSTSA 193
            .|::.       .|:.|:........|||..|.:..:.||    |.|...:...|.     :...
 Frog   128 TSSDG-------QENSSIDISKNHTSTEQNDSPEGRSDLE----EATNSDQRSADS-----TLET 176

Human   194 EDMSENVPIAEDTTEQPKKNRITYSQIIKEGRRFNIDLVSKLLYSRGLLIDLLIKSNVSRYAEFK 258
            ..:.|..|......:|.....||||||:|||||||:|||||.||||||||:||||||||||.|||
 Frog   177 GTIVEVEPSLTQAIQQDSPKTITYSQIVKEGRRFNVDLVSKFLYSRGLLIELLIKSNVSRYTEFK 241

Human   259 NITRILAFREGRVEQVPCSRADVFNSKQLTMVEKRMLMKFLTFCMEYEKYPDEYKGYEEITFYEY 323
            |:||||.:..|::|||||||||||.||||:|||||:|||||...::||.:|::|:.||..||.|:
 Frog   242 NVTRILTYHNGKIEQVPCSRADVFASKQLSMVEKRILMKFLMHYIDYELHPEDYQDYENSTFLEF 306

Human   324 LKTQKLTPNLQYIVMHSIAMTSETASSTIDGLKATKNFLHCLGRYGNTPFLFPLYGQGELPQCFC 388
            ||:::|||.||:.|::||||..|.| .||:||||.::||.|||||||||||||:||.||:|||||
 Frog   307 LKSKQLTPTLQHFVLYSIAMVPENA-KTIEGLKAMQHFLRCLGRYGNTPFLFPMYGLGEIPQCFC 370

Human   389 RMCAVFGGIYCLRHSVQCLVVDKESRKCKAIIDQFGQRIISEHFLVEDSYFPENMCSRVQYRQIS 453
            ||||||||:|||.||::|||||.:|:.|||:||..|:|:..::.:|||||.||.:|:.|.|:|||
 Frog   371 RMCAVFGGVYCLHHSLECLVVDGDSKLCKAVIDHRGKRVDCKYVIVEDSYLPEQICANVSYKQIS 435

Human   454 RAVLITDRSVLKTDSDQQISILTVPAEEPGTFAVRVIELCSSTMTCMKGTYLVHLTCTSSK-TAR 517
            |||||||.|:|.|:|:|:||:||.|..:.|..||.:.|||||||||||.||||||||:|:| ||:
 Frog   436 RAVLITDCSILNTESNQEISVLTFPPADKGQTAVYITELCSSTMTCMKNTYLVHLTCSSTKPTAK 500

Human   518 EDLESVVQKLFVPYTEMEIENEQVEKPRILWALYFNMRDSSDISRSCYNDLPSNVYVCSGPDCGL 582
            ||||.|||:||...||.:||.....||::||||||||||||.:.|..|..||.|||||||||...
 Frog   501 EDLEPVVQQLFTLSTENDIEANDRTKPKVLWALYFNMRDSSGVPRQSYAGLPPNVYVCSGPDHCF 565

Human   583 GNDNAVKQAETLFQEICPNEDFCPPPPNPEDIILDGDSLQPEASESSAIPEANSETFKESTNLGN 647
            |||:||:|||.||.|:.|:|:||||.|||||||.||:..|.|.||||...::.:|...|:..:..
 Frog   566 GNDHAVQQAENLFHELYPSEEFCPPAPNPEDIIYDGECAQQEPSESSIPVDSKAEASAENETVVE 630

Human   648 LEESSE 653
            ..|.||
 Frog   631 SYEDSE 636

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CHM	NP_000381.1	NAD_binding_8	13..>54	CDD:433218	31/40 (78%)
		Rossmann-fold NAD(P)(+)-binding proteins	225..542	CDD:473865	209/317 (66%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	606..653		20/46 (43%)
chm	XP_002938593.1	Rossmann-fold NAD(P)(+)-binding proteins	4..510	CDD:473865	296/525 (56%)