Protein Alignment ADCY6 and Ac78C

DIOPT Version :10

• Sequence 1: NP_056085.1
• Gene: ADCY6 / 112
• HGNCID: 237
• Length: 1168
• Species: Homo sapiens
• Sequence 2: NP_001262138.1
• Gene: Ac78C / 40333
• FlyBaseID: FBgn0024150
• Length: 1727
• Species: Drosophila melanogaster
• Alignment Length: 1403
• Identity: 411/1403 - (29%)
• Similarity: 635/1403 - (45%)
• Gaps: 359/1403 - (25%)

Human    73 RGGPGKGKELGLRAVAL-------------------GFEDTEVTTTAGGTAEVAPDAVPRSGRSC 118
            |||..|...|.:::|.:                   |..:.|....:|.:....|.   :|.|..
  Fly   220 RGGVAKQTPLRVQSVRIVEAKRAYGPKRRTESCSIFGNSNFEHDLESGNSLASIPG---QSQRPL 281

Human   119 WRRLVQVFQS-------------KQFRSAKLERLYQRYFFQMNQSSLTLLMAVLVLLTAVLLAF- 169
            ...:...|:|             ..|:.:.|||.|..|..:..|.|| :::.|:..:..::|||
  Fly   282 NNEMYSAFKSGNVVKGILCPSLTNSFKQSSLERSYLTYTHRQRQKSL-IIVNVVDFVLKIVLAFV 345

Human   170 ------HAAPARPQPAYVALLACAAALFVGL--MVVC---------NRHSFRQDSMW--VVSYVV 215
                  ...|...........|...::..|:  |.:|         |.:..     |  |.::|:
  Fly   346 WIMRRSELGPIESDDGTSMATAITWSVCCGIANMAICFLGYWRCFANNYLH-----WAAVCTWVL 405

Human   216 LGILAAVQVGGALAADPRSPSAGLWCPVFFVYIAYTLLPIRMRAAVLSGLGLSTLHL--ILAWQL 278
            ..|...|..|...|    .....:|..:|.:::.|.:||:.::..|:.|...::.||  |...:|
  Fly   406 FNIQGFVGQGVGFA----DREYLVWYILFVIFVPYAMLPLPLKWCVVGGTITASCHLAVITIIKL 466

Human   279 NRGDAFL-----WKQLGANVLLFLCTNVIGICTHYPAEVSQRQAFQETRGYIQARLHLQHENRQQ 338
            ..|:|.:     ..|:.||.:|:...||.|:.|.|..:..||.||.||...::.:...:.|.::.
  Fly   467 QHGEATINPECVLFQIFANFILYTAINVAGMYTKYLTDRGQRLAFIETHKAMEHKKESEKELQRT 531

Human   339 ERLLLSVLPQHVAMEMKEDINTKKE---DMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQEL 400
            ::||.|:||..|..:::.::....:   :..|:|:|:...||||||||||:|||.|||:.:||:|
  Fly   532 QKLLDSILPNIVNNQIRSEMYKGTDPTVETQFNKLYVYPMDNVSILFADIKGFTELASKTSAQQL 596

Human   401 VMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLP----EARADHAHCCVEMGVDMIEAISLV 461
            |..||:||||||::|.:|||||:|:|||||||||...    :.|.|||.|.||.|:.||:||..|
  Fly   597 VKILNDLFARFDRIAEDNHCLRVKLLGDCYYCVSQFESDNWKTRPDHAVCSVETGLHMIKAIKDV 661

Human   462 REVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNG 526
            |..|.|::|||:|||||.|.|||||.:||.||||||||.:|||||:||..||:||:.|||:.||.
  Fly   662 RLHTHVDLNMRIGIHSGSVMCGVLGNKKWHFDVWSNDVIIANHMESGGIPGRVHISEATLKCLND 726

Human   527 DYEVEPGRGGERNAYLKEQHIETFLIL-------------------------------------- 553
            .||||||.||.|:.:||..:::|:||.
  Fly   727 AYEVEPGNGGCRDNHLKMLNVKTYLIKRTEPLRPKRRFGTRSSAHLAGSVATAAPPCATPTALPK 791

Human   554 -------------------GAS-------------------------QKRK-----------EEK 563
                               |||                         |::|           |..
  Fly   792 SISASGSGSIGGVTATGNDGASIDGRSLEYAATIAVPAQQPTQLLQQQQKKNISLNSLPNVVEGV 856

Human   564 AMLAKLQRTRANSMEG-------------------------------LMPR-------------- 583
            ||.::..|.....|.|                               |.||
  Fly   857 AMDSRRIRNGCGVMGGAGGTGGGGTGPCGMSTVSSPTAMMSAPLEVQLRPRNGACSIQNLAEAID 921

Human   584 -------------WVPDRAFSRTKDSKAFRQMGID-------DSSKDNRGTQDALNPEDEVDEFL 628
                         |:|:..|......    :.|::       |:.:|:|.:...|  ::|:|||:
  Fly   922 GKGLIIEDESTTDWIPEIPFKNLNSP----EDGLNRADSILVDTKEDHRVSVAVL--DEEIDEFI 980

Human   629 SRAIDARSIDQLRKDHVRRFLLTFQREDLEKKYSRKVDPRFGAYVACALLVFCFICFIQLLIFPH 693
            .:.|...|..::|::::..:.|.|:.:..|:|:.:..:..|.:.:.|..:::.|:...|::|.|.
  Fly   981 EQNIQINSNKEIRREYLNPWTLKFKDKSQEQKFCQLREDMFRSNMLCVFVIWIFMVLCQVIIIPR 1045

Human   694 ST-LMLGIYASIFLLLLITVLICAVYSCGSLFPKALQRLSRSIVRSRAHST-------------- 743
            .| |::.:.....:|....||:.|....|  .|:.|:..|..:|..|...|
  Fly  1046 CTRLIICLSVGTVILTFCCVLVMAEEFPG--LPRCLKTNSAKLVHQRQRRTLFICGVIVSMCMLS 1108

Human   744 AVGI--------------FSVLLVFTSAIANM--------------FTCNH------------TP 768
            |:|:              .|..|...|..:|:              .|.:|            ||
  Fly  1109 AIGLVLCPSSTYIGTADEHSRFLRMVSPYSNISMTEKEFKLNVYLSATIHHNITISTPASGGPTP 1173

Human   769 -------------IRSCA-ARMLNLTPADITACH-------------LQQLNYSLGLDAPLCEGT 806
                         :||.. |..||||| .:...|             |..|:||   ||.:.:.:
  Fly  1174 LVDITSSGPSDEFVRSTLNALTLNLTP-PLPQSHRPYTLTTNGHSVSLSNLSYS---DASVMQSS 1234

Human   807 MPT---CSFPEYFIGNMLLSLLASSVFLHISSIGKLAMIFVLGLIYLVLLLLGPPATIFDNYDLL 868
            ...   |:.|||.:...:|.|::.:..|.:..:.|..|...:...|..|:::
  Fly  1235 SDVEGQCAHPEYLVFTWVLCLVSLATALKLYYLVKALMALAMVAFYTTLIMM------------- 1286

Human   869 LGVHGLASSNETFDGLDCPAAGRVALKYMTPVILLVFALALYLHAQQVESTARLDFLWKLQATGE 933
                 ...|.::|..::....| :.|.....::|:.|.:.:..||:.||.|:||||:||.||..|
  Fly  1287 -----KFGSGDSFSLVELSRLG-MPLGVQMLILLISFLVMVCYHARLVEVTSRLDFIWKEQAERE 1345

Human   934 KEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEAN 998
            ...|:..:|.|..|:.||||..||.::|:.| ..||||.:......||||||.||.:||.| :.:
  Fly  1346 LTNMKSNRALNDTLIKNILPDHVATYYLSDE-HTDELYSKMHNLCGVMFASIPNFQDFYSE-DID 1408

Human   999 NEGVECLRLLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASGLN---ASTYDQVGRSHITALA 1060
            | |..|:|:|||||.||||::.|.||..:|||||:|:|||||:|||   .....:.....:..|.
  Fly  1409 N-GKACIRILNEIICDFDELLEEPRFASVEKIKTVGATYMAAAGLNHEHLRLRGETSEDSVCDLV 1472

Human  1061 DYAMRLMEQMKHINEHSFNNFQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDR 1125
            ::|..:.::::.||..:|||||:::|:..||:|:||||||||.||||||||||:|||||||...|
  Fly  1473 EFAFAMKQKLEEINGDAFNNFQLRVGICSGPLVSGVIGARKPVYDIWGNTVNVASRMDSTGENWR 1537

Human  1126 IQVTTDLYQVLAAKGYQLECRGVVKVKGKGEMTTYFLN 1163
            :||..:..::|.::||....||.:.|||||.|||::::
  Fly  1538 VQVPENTAELLCSRGYTCVKRGEIAVKGKGMMTTFYVH 1575

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ADCY6	NP_056085.1	AC_N	<16..368	CDD:318454	75/356 (21%)
		Guanylate_cyc	370..554	CDD:425528	115/244 (47%)
		Adcy_cons_dom	582..669	CDD:461877	21/120 (18%)
		Guanylate_cyc	970..1164	CDD:425528	97/197 (49%)
Ac78C	NP_001262138.1	AC_N	<216..551	CDD:318454	75/343 (22%)
		Guanylate_cyc	566..753	CDD:425528	114/186 (61%)
		Adcy_cons_dom	929..1021	CDD:461877	19/97 (20%)
		Guanylate_cyc	1381..1576	CDD:425528	97/197 (49%)