Protein Alignment SUPT16H and SPT16

DIOPT Version :10

• Sequence 1: NP_009123.1
• Gene: SUPT16H / 11198
• HGNCID: 11465
• Length: 1047
• Species: Homo sapiens
• Sequence 2: NP_011308.1
• Gene: SPT16 / 852665
• SGDID: S000003175
• Length: 1035
• Species: Saccharomyces cerevisiae
• Alignment Length: 1067
• Identity: 375/1067 - (35%)
• Similarity: 586/1067 - (54%)
• Gaps: 96/1067 - (8%)

Human     3 VTLDKDAYYRRVKRLYSNWRKGEDEYANVDAIVVSVG-VDEEIVYAKSTALQTWLFGYELTDTIM 66
            :.:|.|.:.:|::.|||.:.:.|   .:.::::..:| .:.|..|.|:|.|..||..||...|::
Yeast     4 LNIDFDVFKKRIELLYSKYNEFE---GSPNSLLFVLGSSNAENPYQKTTILHNWLLSYEFPATLI 65

Human    67 VFCDDKIIFMASKKKVEFL-KQIANTKGNENANGAPAITLLIREKN----ESNKSSFDKMIEAIK 126
            .....|:|.:.|..|.:.| |.|...|..|:     .|||.:.::|    |.||..||.:|..|.
Yeast    66 ALVPGKVIIITSSAKAKHLQKAIDLFKDPES-----KITLELWQRNNKEPELNKKLFDDVIALIN 125

Human   127 ESKNGKKIGVFSKDKFPGEFMKSWND----CLNKEGFDKIDISAVVAYTIAVKEDGELNLMKKAA 187
            .:  ||.:|:..||.:.|:||..||.    .:.:..|:.||||..::....||:..|...:
Yeast   126 SA--GKTVGIPEKDSYQGKFMTEWNPVWEAAVKENEFNVIDISLGLSKVWEVKDVNEQAFL---- 184

Human   188 SITSEVFNKF---FKERVMEIVDADEKVRHSKLAESVEKAIEEKKYLAGADPSTVEMC------- 242
            |::|:..:||   ....::..||.:.|:.::||::.:|..|::.|:|....|....:|
Yeast   185 SVSSKGSDKFMDLLSNEMVRAVDEELKITNAKLSDKIENKIDDVKFLKQLSPDLSALCPPNYKFN 249

Human   243 -------YPPIIQSGGNYNLKFSVVSDKNHMH-FGAITCAMGIRFKSYCSNLVRTLMVDPSQEVQ 299
                   |.||||||..::|:.|..|..:.:: .|.|..:.|||:.:||||:.||.::|||:|:.
Yeast   250 FDLLDWTYSPIIQSGKKFDLRVSARSTNDQLYGNGCILASCGIRYNNYCSNITRTFLIDPSEEMA 314

Human   300 ENYNFLLQLQEELLKE-LRHGVKICDVYNAVMDVVKKQKPELLNKITKNLGFGMGIEFREGSLVI 363
            .||:|||.||:|::.. |:.|....:||.:|::.::|.||||:...|||:|..:|:|||:.:.::
Yeast   315 NNYDFLLTLQKEIVTNILKPGRTPKEVYESVIEYIEKTKPELVPNFTKNIGSLIGLEFRDSNFIL 379

Human   364 NSKNQY-KLKKGMVFSINLGFSDLTNKEGKKPEEKTYALFIGDTVLV--DEDGPATVLTSVKKKV 425
            |.||.| |:::|..|:|:.||::|.:.:    ....|||.:.|||.:  ||..|...||:..|..
Yeast   380 NVKNDYRKIQRGDCFNISFGFNNLKDSQ----SANNYALQLADTVQIPLDETEPPRFLTNYTKAK 440

Human   426 KNVGIFLKNEDEEEEEEEKDEAEDLLGRGSR-AALLTERTRNEMTA-------EEKRRAHQKELA 482
            ..:..:..||:|:..:::...|..:..:..| :.:|..:.|.|...       |:.|:.:||:|.
Yeast   441 SQISFYFNNEEEDNNKKKSSPATKVPSKPDRNSKILRTKLRGEARGGAEDAQKEQIRKENQKKLH 505

Human   483 AQLNEEAKRRLTEQKGEQQIQKAR---KSNVSYKNPSLMPKEPHIREMKIYIDKKYETVIMPVFG 544
            .:|.:....|.:.........:.|   |...||...|.:|  .:||:::|::|.|.:|:|:|::|
Yeast   506 EKLEKNGLLRFSAADANGPDSEPRQYFKKYESYVRDSQLP--TNIRDLRIHVDWKSQTIILPIYG 568

Human   545 IATPFHIATIKNISMSVEGDYTYLRINFYCPGSALG-RNEGNIFPNPEAT---FVKEITYRASNI 605
            ...||||.:.||.|.:.||:|||||:||..|||:.| ..:....|..|:.   ||:.||.|:.:
Yeast   569 RPVPFHINSYKNGSKNEEGEYTYLRLNFNSPGSSGGISKKVEELPYEESADNQFVRSITLRSKD- 632

Human   606 KAPGEQTVPALNLQNAFRIIKEVQKRYKTREAEEKEKEGIVKQDSLVINLNRSNPKLKDLYIRPN 670
               |::      :...|:.|.:::|....||.|.|....:|:||.|:.|......:|..:::|||
Yeast   633 ---GDR------MSETFKQIADLKKEATKREQERKALADVVQQDKLIENKTGRTKRLDQIFVRPN 688

Human   671 IAQKRMQGSLEAHVNGFRFTS-VRGD-KVDILYNNIKHALFQPCDGEMIIVLHFHLKNAIMFGKK 733
            ...||:..::..|.||.||.| :|.| ::|||::|||:.:||.|.||:|:|:|.||||.|:.|||
Yeast   689 PDTKRVPSTVFIHENGIRFQSPLRTDSRIDILFSNIKNLIFQSCKGELIVVIHIHLKNPILMGKK 753

Human   734 RHTDVQFYTEVGEITTD--------LGKHQHMHDRDDLYAEQMEREMRHKLKTAFKNFIEKVEAL 790
            :..|||||.|..:::.|        ..:.:...|.|:|..||.||..|..|...||.|.:.:...
Yeast   754 KIQDVQFYREASDMSVDETGGGRRGQSRFRRYGDEDELEQEQEERRKRAALDKEFKYFADAIAEA 818

Human   791 TKEELEFEVPFRDLGFNGAPYRSTCLLQPTSSALVNATEWPPF-VVTLDEVELIHFERVQFHLKN 854
            :...|..|..||||||.|.|.||.....||:..||...| ||| |:.|:|||:...|||||.|||
Yeast   819 SNGLLTVENTFRDLGFQGVPNRSAVFCMPTTDCLVQLIE-PPFLVINLEEVEICILERVQFGLKN 882

Human   855 FDMVIVYKDYSKKVTMINAIPVASLDPIKEWLNSCDLKYTEGVQSLNWTKIMKTIVDDPEGFFEQ 919
            ||||.||||::|.||.||.:|:.|||.:|:||...|:.||....:|||..|||::.|||..||..
Yeast   883 FDMVFVYKDFNKPVTHINTVPIESLDFLKQWLTDMDIPYTVSTINLNWATIMKSLQDDPYQFFLD 947

Human   920 GGWSFLEPEGEGSDAEEGDSESEIEDETFNPSEDDYEEEEEDSDEDYSSEAEE---SDYSKESLG 981
            |||:||   ..|||.|..| |||.|...:..||||..:|...|:::..||.::   .|.|::..|
Yeast   948 GGWNFL---ATGSDDEASD-ESEEEVSEYEASEDDVSDESAFSEDEEGSEVDDDISGDESEDYTG 1008

Human   982 SEEESGKDWDELEEEARKADRESRYEE 1008
            .|.|.|:||||||::|.:|||.:.:.:
Yeast  1009 DESEEGEDWDELEKKAARADRGANFRD 1035

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SUPT16H	NP_009123.1	COG5406	5..1001	CDD:227693	372/1056 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	492..518		6/28 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	918..1047		38/94 (40%)
SPT16	NP_011308.1	COG5406	1..1035	CDD:227693	375/1065 (35%)