Protein Alignment SUPT16H and spt16

DIOPT Version :10

• Sequence 1: NP_009123.1
• Gene: SUPT16H / 11198
• HGNCID: 11465
• Length: 1047
• Species: Homo sapiens
• Sequence 2: NP_596526.1
• Gene: spt16 / 2541355
• PomBaseID: SPBP8B7.19
• Length: 1019
• Species: Schizosaccharomyces pombe
• Alignment Length: 1043
• Identity: 399/1043 - (38%)
• Similarity: 620/1043 - (59%)
• Gaps: 64/1043 - (6%)

Human     5 LDKDAYYRRVKRLYSNWRKGEDE---YANVDAIVVSVGV-DEEIVYAKSTALQTWLFGYELTDTI 65
            :|:..:::|:..|.::|:..||.   :.:.|:|:|:||. |:...|.|||||.|||.|||...|:
pombe     6 IDEITFHKRLGILLTSWKNEEDGKTLFQDCDSILVTVGAHDDTNPYQKSTALHTWLLGYEFPSTL 70

Human    66 MVFCDDKIIFMASKKKVEFLKQIANTKGNENANGAPAITLLIREKN-ESNKSSFDKMIEAIKESK 129
            ::....:|..:.|..|...|.::|.|||     .|..:.:|.|.|: |.||..|:|:||.|:.:
pombe    71 ILLEKHRITILTSVNKANMLTKLAETKG-----AAADVNILKRTKDAEENKKLFEKIIEYIRAT- 129

Human   130 NGKKIGVFSKDKFPGEFMKSWNDCLN--KEGFDKIDISAVVAYTIAVKEDGELNLMKKAASITSE 192
             .||:|||.|||..|:|:..|:....  |..|:.:|.|..:|..:|:|::.||..:|.|:.::..
pombe   130 -NKKVGVFPKDKTQGKFINEWDSIFEPVKSEFNLVDASLGLAKCLAIKDEQELANIKGASRVSVA 193

Human   193 VFNKFFKERVMEIVDADEKVRHSKLAESVEKAIEEKKY-------LAGADPSTVEMCYPPIIQSG 250
            |.:|:|.:.:...:|..:|:.|||.::.:|..|:.:.:       |...|...:|.||.||||||
pombe   194 VMSKYFVDELSTYIDQGKKITHSKFSDQMESLIDNEAFFQTKSLKLGDIDLDQLEWCYTPIIQSG 258

Human   251 GNYNLKFSVVSDKNHMHFGAITCAMGIRFKSYCSNLVRTLMVDPSQEVQENYNFLLQLQEELLKE 315
            |:|:||.|.::|..::|...:.|::|.|:||||||:.||.:.||..|.|:||:||:.||::|.:.
pombe   259 GSYDLKPSAITDDRNLHGDVVLCSLGFRYKSYCSNVGRTYLFDPDSEQQKNYSFLVALQKKLFEY 323

Human   316 LRHGVKICDVYNAVMDVVKKQKPELLNKITKNLGFGMGIEFREGSLVINSKNQYKLKKGMVFSIN 380
            .|.|..|.|:|..::.:::.::|:|.....:|||.|:||||||.||::|:||...|:.||..:::
pombe   324 CRDGAVIGDIYTKILGLIRAKRPDLEPNFVRNLGAGIGIEFRESSLLVNAKNPRVLQAGMTLNLS 388

Human   381 LGFSDLTNKEGKKPEEKTYALFIGDTVLVDEDGPATVLTSVKKKVKNVGIFLKNEDEEEEEEEKD 445
            :||.:|.|...|..:.|.|||.:.||:.:....| .|.|...|...::..|...:|...|:..|.
pombe   389 IGFGNLINPHPKNSQSKEYALLLIDTIQITRSDP-IVFTDSPKAQGDISYFFGEDDSSLEDGVKP 452

Human   446 EAEDLLGRGSRAALLTE---RTRNEM-----TAEEKRRAHQKELAAQLNEEAKRRLTEQKGEQQI 502
            ......|    .|.::.   :||:|.     :||::|..|||:||::...|..:|..:  |....
pombe   453 RKPPTRG----TATISSHKGKTRSETRDLDDSAEKRRVEHQKQLASRKQAEGLQRFAQ--GSVPS 511

Human   503 QKARKSNV----SYKNPSLMPKEPHIREMKIYIDKKYETVIMPVFGIATPFHIATIKNISMSVEG 563
            ....|..|    |||..|.:|:.  |.|::|.:|.:.:::|:|:||...||||:|:||.|.:.||
pombe   512 SGIEKPTVKRFESYKRDSQLPQA--IGELRILVDYRAQSIILPIFGRPVPFHISTLKNASKNDEG 574

Human   564 DYTYLRINFYCPGSALGRNEGNIFPNPEATFVKEITYRASNIKAPGEQTVPALNLQNAFRIIKEV 628
            ::.|||:||..||...|:.:...|.:|.|.|::..|:|:||..          .:...|:.|:::
pombe   575 NFVYLRLNFVSPGQIGGKKDELPFEDPNAQFIRSFTFRSSNNS----------RMSQVFKDIQDM 629

Human   629 QKRYKTREAEEKEKEGIVKQDSLVINLNRSNPKLKDLYIRPNIAQKRMQGSLEAHVNGFRFTS-V 692
            :|....||.|.||...:::||.|:...|:....:.|:|:||.|..||:.|.:|.|.||.|:.| :
pombe   630 KKAATKRETERKEFADVIEQDKLIEIKNKRPAHINDVYVRPAIDGKRLPGFIEIHQNGIRYQSPL 694

Human   693 RGDK-VDILYNNIKHALFQPCDGEMIIVLHFHLKNAIMFGKKRHTDVQFYTEVGEITTD-LG--K 753
            |.|. :|:|::|:||..||||:||:|:::|.|||..||.||::..|||||.||.:|..| .|  |
pombe   695 RSDSHIDLLFSNMKHLFFQPCEGELIVLIHVHLKAPIMVGKRKTQDVQFYREVSDIQFDETGNKK 759

Human   754 HQHMH-DRDDLYAEQMEREMRHKLKTAFKNFIEKVEALTKEELEFEVPFRDLGFNGAPYRSTCLL 817
            .::|: |.|:|..||.||..|.:|...||:|.||:...::..:|.::|||:|.|||.|:||..||
pombe   760 RKYMYGDEDELEQEQEERRRRAQLDREFKSFAEKIAEASEGRIELDIPFRELAFNGVPFRSNVLL 824

Human   818 QPTSSALVNATEWPPFVVTLDEVELIHFERVQFHLKNFDMVIVYKDYSKKVTMINAIPVASLDPI 882
            |||:..||..|:.|..|:||:|:|:.|.|||||.|||||:|.:::|:.:....||.||:..||.:
pombe   825 QPTTDCLVQLTDTPFTVITLNEIEIAHLERVQFGLKNFDLVFIFQDFRRPPIHINTIPMEQLDNV 889

Human   883 KEWLNSCDLKYTEGVQSLNWTKIMKTIVDDPEGFFEQGGWSFLEPEGEGSDAEEGDSESEIEDET 947
            ||||:|||:.:.||..:||||.||||:.:||..|||:|||.||   |..||.|..||..|:.:
pombe   890 KEWLDSCDICFYEGPLNLNWTTIMKTVNEDPIAFFEEGGWGFL---GAPSDDEGDDSVEEVSE-- 949

Human   948 FNPSEDDYEEEEEDSDEDYSSEAEESDYSKESLGSEEESGKDWDELEEEARKAD-RESRYEEEEE 1011
            :..|:.|..:|||:..|:||.:|.|.|...||...:||||:||||||.:||:.| :...:||...
pombe   950 YEASDADPSDEEEEESEEYSEDASEEDGYSESEVEDEESGEDWDELERKARQEDAKHDAFEERPS 1014

Human  1012 QSR 1014
            :.|
pombe  1015 KKR 1017

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SUPT16H	NP_009123.1	COG5406	5..1001	CDD:227693	395/1027 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	492..518		8/29 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	918..1047		42/98 (43%)
spt16	NP_596526.1	COG5406	1..1018	CDD:227693	399/1043 (38%)