Protein Alignment SUPT16H and spt-16

DIOPT Version :10

• Sequence 1: NP_009123.1
• Gene: SUPT16H / 11198
• HGNCID: 11465
• Length: 1047
• Species: Homo sapiens
• Sequence 2: NP_492821.1
• Gene: spt-16 / 172984
• WormBaseID: WBGene00018849
• Length: 1030
• Species: Caenorhabditis elegans
• Alignment Length: 1053
• Identity: 500/1053 - (47%)
• Similarity: 700/1053 - (66%)
• Gaps: 40/1053 - (3%)

Human     5 LDKDAYYRRVKRLYSNWRKGEDEYANVDAIVVSVGVDEEIVYAKSTALQTWLFGYELTDTIMVFC 69
            |:||.:::|.:|||.:|.||.|...::.::....| :.:..|.|::||.|||||:|:.||:::..
 Worm     8 LNKDLFFQRAERLYEHWEKGADGLDSIKSLAFVYG-ETDNPYTKTSALFTWLFGHEIADTVLLLL 71

Human    70 DDKIIFMASKKKVEFLKQIANTKGNENANGAPAITLLIREKNESNKSSFDKMIEAIKESKNGKKI 134
            .|.|..:.|.:||||...:  |..|:::...|.::.|:|:|.:.:..:|:|:|:.||.:  |..:
 Worm    72 KDHIYILGSNRKVEFFGSV--TGDNQSSGKVPTVSTLLRDKTDKDAGNFEKLIDHIKSA--GGDV 132

Human   135 GVFSKDKFPGEFMKSWNDCLNKEGFDKIDISAVVAYTIAVKEDGELNLMKKAASITSEVFNKFFK 199
            |.|.|:||..||:.|||..|.:.|.:|.|::....:..|||:|.|::|::|:|..|:..:.. .:
 Worm   133 GNFVKEKFSSEFVSSWNKALEEGGVNKNDVTLAFTHLFAVKDDKEMDLIRKSAQATTASWTA-AR 196

Human   200 ERVMEIVDADEKVRHSKLAESVEKAIEEKKYLAGADPSTVEMCYPPIIQSGGNYNLKFSVVSDKN 264
            .|.:||:|.:::||||.|:......:::.|..........:.||.||:.|||||:.|::..|.::
 Worm   197 ARYVEIIDQEKRVRHSVLSNEFAAFMKDSKVQQALAKYEADTCYDPIVMSGGNYSFKWNHESSES 261

Human   265 HMH--FGAITCAMGIRFKSYCSNLVRTLMVDPSQEVQENYNFLLQLQEELLKELRHGVKICDVYN 327
            |:|  ||.|..:.|.|...||:||.||:::.||.|::..|..:|..:..::..|:.|.|:.|||.
 Worm   262 HLHSQFGTIITSFGARLSEYCTNLTRTMLIFPSSELETAYEAILAAELAVIAALKPGAKLSDVYK 326

Human   328 AVMDVVKKQKPEL---LNKITKNLGFGMGIEFREGSLVINSKNQYKLKKGMVFSINLGFSDLTNK 389
            ..:|.:.::.|:|   |||  |.|||..||||||..|.|::|....:|.||||.:.:|...:.||
 Worm   327 IGIDTLTEKSPKLAETLNK--KELGFATGIEFRESRLAISAKCDEVVKAGMVFIVYIGVDSIPNK 389

Human   390 EGKKPEEKTYALFIGDTVLVDEDGPATVLT-SVKKKVKNVGIFLKNEDEEEEEEEKDEAEDLLGR 453
             .|..:.|..|:.|.||:||.|:|...:|| ..|.::|:..|..|.|.|..|.|:.::.:.:|||
 Worm   390 -NKGEKGKPAAIAISDTILVKEEGDNEILTEKAKSRLKSNVIKFKEEQENREAEKDNDQKKMLGR 453

Human   454 GSRAALLTERTRNEMTAEEKRRAHQKELAAQLNEEAKRRLTEQKGEQQIQKARKSNVSYKNPSLM 518
            |.|:.:||::|||:.|.||.|:..||||..||||.||.||::|.|....:|::|||||||.....
 Worm   454 GQRSVVLTDQTRNKTTNEELRKERQKELGVQLNELAKARLSKQGGGTDEKKSKKSNVSYKTEERF 518

Human   519 PKEPHIREMKIYIDKKYETVIMPVFGIATPFHIATIKNISMSVEGDYTYLRINFYCPGSALGRNE 583
            |::..:::|.|::|:||::|::|:|||..||||:.|||.|.|||||:|||||||..|||.:|::.
 Worm   519 PQDADVQKMLIFVDRKYDSVVVPIFGIPVPFHISMIKNCSQSVEGDFTYLRINFATPGSQVGKDS 583

Human   584 GNIFPNPEATFVKEITYRASNIK-APGEQTVPALNLQNAFRIIKEVQKRYKTREAEEKEKEGIVK 647
            |. ||:|.|.::||:|:|||||| ...:.|.|:.||..|||:|||:|||:||.||||:||||.||
 Worm   584 GQ-FPHPLAHYMKELTFRASNIKDHHSDSTAPSHNLSTAFRLIKEMQKRFKTEEAEEREKEGAVK 647

Human   648 QDSLVINLNRSNPKLKDLYIRPNIAQKRMQGSLEAHVNGFRFTSVRGDKVDILYNNIKHALFQPC 712
            ||.|:::.|:.|||||||.|||||.|||:.||||||.||||:||:|||::|:||||||||.||||
 Worm   648 QDKLILSQNKLNPKLKDLLIRPNIIQKRITGSLEAHTNGFRYTSLRGDRIDVLYNNIKHAFFQPC 712

Human   713 DGEMIIVLHFHLKNAIMFGKKRHTDVQFYTEVGEITTDLGKHQHMHDRDDLYAEQMEREMRHKLK 777
            |.||||:|||||||.:::|||::.|||||||||||||||||:.||.||||:.:||.|||||.:|.
 Worm   713 DNEMIILLHFHLKNPVLWGKKKYKDVQFYTEVGEITTDLGKYHHMQDRDDMQSEQQEREMRRRLN 777

Human   778 TAFKNFIEKVEALTKEELEFEVPFRDLGFNGAPYRSTCLLQPTSSALVNATEWPPFVVTLDEVEL 842
            .||.:|.|||..||.::.||:.||..|||.|.||||...|:||:|.|||.||||.|:|||.||||
 Worm   778 AAFNSFCEKVSRLTNDQFEFDSPFAGLGFFGVPYRSATTLKPTASCLVNLTEWPTFIVTLSEVEL 842

Human   843 IHFERVQFHLKNFDMVIVYKDYSKKVTMINAIPVASLDPIKEWLNSCDLKYTEGVQSLNWTKIMK 907
            :|||||...|||||||.::|||..|..|:..||::|:|.|||||::||:.|:||:|||||.|:||
 Worm   843 VHFERVSLQLKNFDMVFIFKDYKIKPQMVAQIPMSSIDKIKEWLHTCDIWYSEGIQSLNWAKVMK 907

Human   908 TIVDDPEGFFEQGGWSFLEPEGEGSDAEEGDSESEIEDETFNPSEDDYEE---EEEDSDEDYSSE 969
            ||.||.|.|||:||||||..|   ||.||...:|: :.:.::|.|:|...   .|.|.||....|
 Worm   908 TITDDLEAFFEEGGWSFLNVE---SDNEEAMDDSD-DSDAYDPEEEDASAGSGSESDEDESEGEE 968

Human   970 AEESDYSKESLGSEEESGKDWDELEEEARKADRESRYEEEEEQSRSMSRKRKASVHSSGRGSNRG 1034
            .|..|..:.||.|:|..||||.:|||||..||:.   .|.||.||...|||.   |||
 Worm   969 TESDDDDEGSLDSDESEGKDWSDLEEEAANADKR---REVEEPSRDRDRKRP---HSS------- 1020

Human  1035 SRHSSAPPKKKRK 1047
               .|.|..|:||
 Worm  1021 ---KSGPSHKRRK 1030

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SUPT16H	NP_009123.1	COG5406	5..1001	CDD:227693	482/1005 (48%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	492..518		12/25 (48%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	918..1047		52/131 (40%)
spt-16	NP_492821.1	COG5406	8..1013	CDD:227693	489/1021 (48%)