DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment WIF1 and wif1

DIOPT Version :9

Sequence 1:	NP_009122.2	Gene:	WIF1 / 11197	HGNCID:	18081	Length:	379	Species:	Homo sapiens
Sequence 2:	NP_571304.1	Gene:	wif1 / 30476	ZFINID:	ZDB-GENE-990712-17	Length:	378	Species:	Danio rerio

Alignment Length:	381	Identity:	265/381 - (69%)
Similarity:	316/381 - (82%)	Gaps:	7/381 - (1%)

- Green bases have known domain annotations that are detailed below.

Human     1 MARRSAFPAAALWLWSILLCLLALRAEAGPPQEESLYLWIDAHQARVLIGFEEDILIVSEGKMAP 65
            ||.|:  ||..|.|.:.:|.||....||...:..::|:||||:|||:||||||||||||||||||
Zfish     1 MAFRT--PAVQLHLKACVLLLLGGLLEAAYQERGTMYMWIDANQARILIGFEEDILIVSEGKMAP 63

Human    66 FTHDFRKAQQRMPAIPVNIHSMNFTWQAAGQAEYFYEFLSLRSLDKGIMADPTVNVPLLGTVPHK 130
            ||||||||||||||||||||.:||||||..||||||||.:||||||.||.||||||||||:||||
Zfish    64 FTHDFRKAQQRMPAIPVNIHHVNFTWQATDQAEYFYEFQTLRSLDKDIMDDPTVNVPLLGSVPHK 128

Human   131 ASVVQVGFPCLGKQDGVAAFEVDVIVMNSEGNTILQTPQNAIFFKTCQQAECPGGCRNGGFCNER 195
            ||||||||||.|.|||||||||.::||::.||.||:||.|||||||||:|:|||||||||:||||
Zfish   129 ASVVQVGFPCRGDQDGVAAFEVTILVMDAGGNIILRTPHNAIFFKTCQRAKCPGGCRNGGYCNER 193

Human   196 RICECPDGFHGPHCEKALCTPRCMNGGLCVTPGFCICPPGFYGVNCDKANCSTTCFNGGTCFYPG 260
            ::|||.|||:|.|||||||:|||:|||||::||.||||||::|.:|::|||||||.||||||:||
Zfish   194 QVCECQDGFYGVHCEKALCSPRCLNGGLCMSPGVCICPPGYFGSSCERANCSTTCLNGGTCFHPG 258

Human   261 KCICPPGLEGEQCEISKCPQPCRNGGKCIGKSKCKCSKGYQGDLCSKPVCEPGCGAHGTCHEPNK 325
            ||||....||.:||:|||.|||||||||.|::||||||||.||||||.||||.|||||||.|||:
Zfish   259 KCICAVSFEGVRCELSKCRQPCRNGGKCTGRNKCKCSKGYHGDLCSKAVCEPSCGAHGTCVEPNR 323

Human   326 CQCQEGWHGRHCNKRYEASLIHALRPAGAQLRQHTPSL---KKAEERRDPPESNYI 378
            |||:|||||||||||:...:.::.|.:.:  :..:||:   |:|.|...|.|:||:
Zfish   324 CQCREGWHGRHCNKRFRGGVSNSQRVSPS--KHKSPSVAAAKEAPETSQPSETNYV 377

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
WIF1	NP_009122.2	WIF	35..179	CDD:128745	118/143 (83%)
WIF1	NP_009122.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	354..379		9/28 (32%)
wif1	NP_571304.1	WIF	34..177	CDD:295401	118/142 (83%)
wif1	NP_571304.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	343..378		10/37 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194343350
Domainoid	1	1.000	233	1.000	Domainoid score	I10566
eggNOG	1	0.900	-	-		E1_KOG1225
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H31430
Inparanoid	1	1.050	588	1.000	Inparanoid score	I5420
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG47613
OrthoDB	1	1.010	-	-		D1016037at2759
OrthoFinder	1	1.000	-	-		FOG0007895
OrthoInspector	1	1.000	-	-		oto50753
orthoMCL	1	0.900	-	-		OOG6_109902
Panther	1	1.100	-	-	LDO	PTHR14949
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4825
SonicParanoid	1	1.000	-	-		X8044
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	1	1.500	-	-
	18	18.340