Protein Alignment CEP250 and Root

DIOPT Version :10

• Sequence 1: NP_009117.2
• Gene: CEP250 / 11190
• HGNCID: 1859
• Length: 2442
• Species: Homo sapiens
• Sequence 2: NP_651216.2
• Gene: Root / 42860
• FlyBaseID: FBgn0039152
• Length: 2048
• Species: Drosophila melanogaster
• Alignment Length: 2534
• Identity: 534/2534 - (21%)
• Similarity: 975/2534 - (38%)
• Gaps: 732/2534 - (28%)

Human    27 LQQQMAENQAASWRKLKNSQEAQQRQATLVRKLQAKVLQYRSWCQELEKRL------------EA 79
            |:|::|:...:..|:|...::||..||.||.:||:|:.|||..|.:||:|:            :.
  Fly    98 LRQRLADESHSYRRRLDTYKQAQHNQANLVSRLQSKIQQYRQRCSDLEERMHETIKPTAGVGPKL 162

Human    80 TGGPIPQRW---------------ENVEEP-------NLDELLV------------RLEEEQQRC 110
            |.||..|..               .:::.|       .:|::||            :||||.|||
  Fly   163 TTGPTNQVLCSTSLTLGQSSLPCSSSLDSPPPSCSRDYVDDVLVTGGGAGAAELCRKLEEEHQRC 227

Human   111 ESLAEVNTQLRLHMEKADVVNKALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHG 175
            |.:...|:.||..:|:::..|:||..|::|||.||:..||||:.||.:::.|::.||.|...||.
  Fly   228 EQIVAQNSALRQQLEESNRTNEALTNDLQKLTNDWASLRDELLIKEDEFKEEEQAFKDYYNSEHN 292

Human   176 RLLSLWREVVTFRRHFLEMKSATDRDLMELKAE------HVRLSGSLLTCCLRLTVGAQSREPNG 234
            |||.:|||||..:|.|.||::|...::.::..|      .:..|.:.:...::....|...|...
  Fly   293 RLLKMWREVVAVKRSFKEMQTAMKAEVAKMGQEINCVGKDINGSNATVAFAVQQAKRAADDELKQ 357

Human   235 SGRMDGREPAQLLLLLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQN 299
            |.|.:.....||..|..:.:....|..||.|.|::|.:|  |:|  |:||..:..:....:.:.:
  Fly   358 SQRSNDELQNQLATLKVQYESARHEIMERDQRLLELMNQ--LKK--LEDRCAQAESQAALASRYS 418

Human   300 EDYEKMIKALRETVE-ILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGS 363
            ::.|::..::||..: :::.......|.:|.::....:.    ..:.:|...|:...|...:...
  Fly   419 DEIERLNNSMREIAQAVVQDAENADREADAEVTGGVMQH----MHLTRDAASVVGGAGGAGSTAG 479

Human   364 GHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEE 428
            |...|...:|:..||   ..|:..::.|::.|.:.:.|:.|::.:.....|.:...:.|.:..|.
  Fly   480 GGGKSPRRNSTRASQ---AFAEGTISAVQAALHKYQLALHDMQVKFQNTSETLRTTKAQLETSEG 541

Human   429 EGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQ--------------L 479
            ..:.|..::|:||.:.|:       ...::..|.:|||.||:..:::|.|              .
  Fly   542 TKQLLTTKMQQLTEKLDS-------SNSKLSELLQERESLQRGLDDIRVQKQQSEMGRADINSAF 599

Human   480 EVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELIT 544
            |.|..:..:::....:||.:.||.:..|:..:.|:...::::...:..|...|.:.|....|.|:
  Fly   600 ENLSSDYEKMQLNCGKLQKRIDSMEEDKKAVELEIQRILKDKNITELNLRSEEDRSSRLREETIS 664

Human   545 LREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALA 609
            |||.|....|..:||.|::.|....:...|:..::|....:.|..|..||:....|||. |....
  Fly   665 LREELNRVSLNRDLLEQQRIESDNLINLLEKQKSDLEYDLDKLLLEKCDLQEKHEKLSN-NSCST 728

Human   610 LDKVGLNQQLLQ-LEEENQSVCSRMEAAEQAR--NALQVDLAEAEKRREALWEKNTHLEAQLQKA 671
            .|::...|..|| .:||.:.:  |:::.:|..  ..|:.:||..:|.|..|...|.....:|:..
  Fly   729 SDELKSVQNCLQEAQEERKKL--RIQSVDQCNEIGELKKELAILDKARLELETDNLSAGEKLKCL 791

Human   672 EEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVR 736
            :....::..||..:..::.:|..:|:....::||...:|.:..|..::..|..:|..:..|.:|:
  Fly   792 QLEKEKILQDLACVTRDRGDIHNQLTAMCRKKEALNEELMRTRQRLEQTTETNSRLNRNLEEMVK 856

Human   737 EKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAK 801
            :....:|.:...|:|...|.|.|..|.|.||.|||.||:........|..:.|||..:|.....:
  Fly   857 DVEEKQVVIDLHEKDTHRLNELLAALRSEKESLESVLFDTNTSLEATEERRSQLERDLQEALVRE 921

Human   802 EVIQGEVRCLKLELDTERSQAEQERDAA--ARQLAQAEQEGKTA-----LEQQKAAHEKEVNQLR 859
            |.::..|..|:.||:..:.:|::.:...  |.:.|:::...|.|     .|:....|.:|:.|||
  Fly   922 ESLKNHVARLQKELEQCQRKAQETKTQLLNAARAAESDFNQKIANLQACAEEAAKRHGEEILQLR 986

Human   860 EKWEKERSWHQQELAKALESLEREKME-LEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLET 923
            ...||    ..|:..:||::.:.:::| |:.||...|..:|::..|.||...:|||...|..|..
  Fly   987 NALEK----RMQQALQALQTAKDDEIEKLQERLATLQAHLESLVQQHEEALIRAESEKQQALLIA 1047

Human   924 EKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGIL-------QTQLQEAQRELK 981
            .:::.::.|.|....::|....:.|:|.|::...:..|::.....|       :|:.:|.:.:|:
  Fly  1048 HRDKQAVAERLEAVSRDLKTEQESLDRSRREANARDEKQRAAIAQLKDEMVQMRTKEEEHKIKLE 1112

Human   982 EAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRI 1046
            |..|:....|::|:||..||.       :..|:||.::..::|.......|:|:.||:::|....
  Fly  1113 ECIRKQELQLSSLREERESLC-------RVSEELKMEIRLKEDRMESTNNELQDALRKSKEGEGF 1170

Human  1047 QKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVK 1111
                                       .||:| :||:..|:.:.::..|:.:.|...:.||..||
  Fly  1171 ---------------------------IDSLR-KELTDCRRQLADSNIERDKYSGSNKELRDHVK 1207

Human  1112 EKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQA 1176
            ..|:                               ||..|
  Fly  1208 RVES-------------------------------AKREQ------------------------- 1216

Human  1177 QAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAV 1241
                                                                         |.|:
  Fly  1217 -------------------------------------------------------------ARAI 1220

Human  1242 ASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEG 1306
            ..||.|                  :..||:.....|.|::::.|.|::.:...::..:
  Fly  1221 EEALQK------------------ISNLEDTKNSLENERTRLSTILKETENHFTKTTQ------- 1260

Human  1307 KQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQA 1371
                      :|:.|.|.||.                           ||||..|
  Fly  1261 ----------DLNATKAQLQK---------------------------AQVEFAQ---------- 1278

Human  1372 SAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEE 1436
                                              :::|      ||.||..|....:.....::|
  Fly  1279 ----------------------------------KDEG------GKELQCKLVAEVELKERAQQE 1303

Human  1437 VETLRGQIQELE-----KQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAV 1496
            :..::.|:.:||     .::|:.:|..:        .|||                  ||   ..
  Fly  1304 LCQIKKQLSDLEANLCATRQELGRARCQ--------NNQE------------------EH---RF 1339

Human  1497 QEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQ----RGQVQDLKKQLVTLEC 1557
            ..|||:|..:.|:.|..||..|.|::.||..|.:..::.|.::::    .|:::.|.:|   |.|
  Fly  1340 HAREQELAQRLEEGRGREKRLEDQKHNLEVCLADATQQIQELKARLGGAEGRIRALDEQ---LSC 1401

Human  1558 LALELEENHHKMECQQKL------IKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLES 1616
            :.|      ||.:.:|||      ::.:.|.:....|.|:|..|....|.    :.|....|.::
  Fly  1402 VEL------HKRDTEQKLSSVVHTLRRIAGIQVDGSVNLSHRLLSPSRRF----SPSRSCGDYDN 1456

Human  1617 HSTV------------LARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQV 1669
            .||.            |.|      :.|::...|:.:|:|:|:..       ..:|...|:::|.
  Fly  1457 RSTSQCPDGPIDVDPDLVR------KGVRNLMHQVAQLEREKDDY-------KSQLGAAKKQLQD 1508

Human  1670 LEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDK 1734
            ..||:.|                                        ..|:.|.|:.|
  Fly  1509 AADQQLR----------------------------------------CDAKLGKLQAM------- 1526

Human  1735 EKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQ 1799
                      :..|||.|..||                 :.|:.:|..:|           ..|:
  Fly  1527 ----------LRNLQEEKSNLE-----------------TDRKMKISAIQ-----------ALEE 1553

Human  1800 SLQSQLDEAQ---RALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGEL 1861
            .|:.:.||.|   ..|||.:.:|.|..:|    .||.|...||:              :::..:|
  Fly  1554 KLKHRNDECQMLRERLAQTEMQLAATSEE----NGQNEERLEKS--------------RQQCSKL 1600

Human  1862 QDHKEQARRLEEELA-VEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQ 1925
            .:.|   |:|:|||| ||||                                 |.:.|::..|::
  Fly  1601 DNEK---RQLQEELAKVEGR---------------------------------ASKLELQRVAME 1629

Human  1926 DSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAEL 1990
            ....:.|..|:|:|..:                 |..||.|:            .:...|.|
  Fly  1630 GDLTRLQMALQEKDCSI-----------------RQMAERLE------------NQNRALTQ--- 1662

Human  1991 SRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQ 2055
               ||.....|::::|       ||:|  |:|:..:.:..||  .:::.||:.|:::....:..:
  Fly  1663 ---LEDRCTALKSTVD-------QLKE--RLQKSAVSETQLR--GEIKTLQKELSEQGHCSQANE 1713

Human  2056 EREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRN 2120
            ::.:|::||                                    |..|:.|:.||..|....:.
  Fly  1714 DKLKLVQKS------------------------------------LQTAENEKRILTERLDSAQT 1742

Human  2121 NLEALPHSHKTSPMEEQSLKLDSLEPRLQRELERL--QAALRQTEAREIEWREKA---QDLALSL 2180
            ||..|..|        |..:||. ..|||.::..|  |.:..:::.|..:|.:::   :|    |
  Fly  1743 NLNELRRS--------QQAQLDG-NQRLQEQVTDLEVQRSALESQLRIAKWNQESGGDKD----L 1794

Human  2181 AQTKASVSSLQEVAMFLQASVLERD---SEQQRLQD---ELELTRRA----------LEKERLHS 2229
            .......:..:|::..|::|..|:.   |:.|.|||   :||..|::          .||.....
  Fly  1795 TNGNGGGNGEEELSRQLKSSQREKSELRSKLQTLQDKVKQLECDRKSKFSGGNAYDRAEKSNSFY 1859

Human  2230 PGATSTAELGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNV 2294
            .||..:.|..| ....|..|...|....   .|::.....|....|:..|.|||...:..:....
  Fly  1860 GGAAESGEFDS-NRYDVGGGNAGGGSFN---CGLDHSVIEQETRDLRLKVRRLETLLAEKESELA 1920

Human  2295 QLRSTLEQVERERRKLKREAMRAAQAGSLEISKATASSPTQQDGRGQKNSDAKCVAELQKEVVLL 2359
            :.::.:....:....|..:..|:||..:.::..|...|..||            |..|:.::.:|
  Fly  1921 RCKARMNDSAKCHDGLDGDRYRSAQMHAEKLLDAREQSHRQQ------------VLRLENQISML 1973

Human  2360 QAQLTLERKQKQDYITRSAQTSRELAGLHHSLSHSLLAVAQAP-EATVLEAETRRLDESLTQSL 2422
            :.||..|.|::|.||.||::.:||:..|..:|..||..|:|.| :..:||:|:||||.:::.||
  Fly  1974 REQLAQEAKRRQQYILRSSKANREMQHLRSTLGDSLRNVSQHPVDPHLLESESRRLDSAVSMSL 2037

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CEP250	NP_009117.2	Rootletin	39..213	CDD:464459	73/225 (32%)
		EnvC	246..>491	CDD:443969	50/259 (19%)
		Smc	<429..1052	CDD:440809	156/654 (24%)
		SMC_prok_B	790..1552	CDD:274008	136/785 (17%)
		SMC_prok_B	1259..2019	CDD:274008	142/790 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1273..1308		4/34 (12%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1699..1725		2/25 (8%)
		Smc	<1746..>2313	CDD:440809	118/591 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1820..1839		5/18 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2223..2244		6/20 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2307..2345		8/37 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2416..2442		2/7 (29%)
Root	NP_651216.2	Rootletin	110..330	CDD:464459	73/219 (33%)
		Gp58	<336..>604	CDD:369586	56/285 (20%)
		SMC_prok_B	503..1314	CDD:274008	208/1088 (19%)
		SMC_prok_B	991..>1779	CDD:274008	237/1340 (18%)