Protein Alignment PKP3 and pkp3a

DIOPT Version :10

• Sequence 1: NP_001289958.1
• Gene: PKP3 / 11187
• HGNCID: 9025
• Length: 812
• Species: Homo sapiens
• Sequence 2: NP_001038745.1
• Gene: pkp3a / 368397
• ZFINID: ZDB-GENE-060512-114
• Length: 869
• Species: Danio rerio
• Alignment Length: 874
• Identity: 365/874 - (41%)
• Similarity: 511/874 - (58%)
• Gaps: 114/874 - (13%)

Human    27 RPEAGVCSLALPSDLQLDRRGAEGPEAERLRAARVQEQVRARLLQLGQQPRHNGAAEPEPEAETA 91
            :|.:.|.:.|:||:.:|      |...|..|..|:|:||..||.:....||.||::.....:|:.
Zfish    16 QPNSTVSTYAVPSENEL------GSHKEESRFKRMQQQVSMRLAEKSTLPRQNGSSSQYASSESG 74

Human    92 RGTSRGQYHTLQAGFSSRSQGLSGDKTSGFRPIA-KPA-YSPASWSSRSAVDLSCSRRLSSAHNG 154
            ..::..:|.|:...|.......|...:||.:.:| :|: |....:||||||:.:...::|....|
Zfish    75 NYSTMTKYSTVGQNFIPSFSSKSFVNSSGRQMMAQRPSQYLSGGFSSRSAVEFTPRAKMSYTAGG 139

Human   155 GSA---------FGAAGYGGA---------------QPTPPMPTRPVSFHERGGVGSRADYDTLS 195
            |..         |.:..|||.               |......||.:|  ..||     |.:|||
Zfish   140 GGGGGSSYYQEDFASGDYGGGGYQSGGYQISGGQVQQQQVNKVTRSLS--RMGG-----DPETLS 197

Human   196 LRSLRLG--PGGL--------DDRYSLVSEQ----LEPAATSTYRAFAYERQASSSSSRAGGLDW 246
            :.|:|:.  |..:        |...|:|||:    .:.:.::.|.|..|.||:..|:|...|.:.
Zfish   198 MHSMRVSAIPQQVVSSWVAQEDSDGSMVSERDATYTQRSMSNGYAANTYPRQSMYSNSNMNGFES 262

Human   247 PE-------------------AT------------EVSPSR-TIRAPAVRTLQRFQSSHRSR--- 276
            .:                   ||            ||..|| :.:.||.||:.|..:....|
Zfish   263 AQQQVSSMTLPTMKRSLSGTLATSSGGGGGGAVEQEVYVSRQSFKGPAHRTISRINNRQTLRTSS 327

Human   277 ------GVGGAVPGA-----VLEP--VARAPSVRSLSLSLADSGHLPDV-HGFNSYGSHRTLQRL 327
                  |.||...|:     :::.  ::||.||||:.    ..|...|| .|.:..||...|
Zfish   328 VQSGMFGSGGGFSGSQGNLYMMQQGRLSRAGSVRSIH----SVGRGKDVFDGMDMAGSMGNL--- 385

Human   328 SSGFDDIDLPSAVKYLMASDPNLQVLGAAYIQHKCYSDAAAKKQARSLQAVPRLVKLFNHANQEV 392
             ||.:.:|:|:|:.||..||..||:|||||:||:|||:..||||...|:.:||||:|||..||||
Zfish   386 -SGLNSLDMPTAINYLDQSDQELQMLGAAYVQHECYSNKDAKKQVNQLKGIPRLVQLFNSDNQEV 449

Human   393 QRHATGAMRNLIYDNADNKLALVEENGIFELLRTLREQDDELRKNVTGILWNLSSSDHLKDRLAR 457
            ||.||||.|||||:|.:||:||:|..||.:|::.|:.:||||.||:|||||||||.|:||:||||
Zfish   450 QRFATGATRNLIYENMENKVALIEAGGIPKLIQALKVEDDELHKNITGILWNLSSKDNLKERLAR 514

Human   458 DTLEQLTDLVLSPLSGAGGPPLIQQNASEAEIFYNATGFLRNLSSASQATRQKMRECHGLVDALV 522
            :.|.:|||.:|.||||.|...:|:.|.||::||:|.||.|||:||.::.|||.|||..||:||||
Zfish   515 EILPELTDKILIPLSGTGDQDIIEMNPSESDIFFNTTGCLRNMSSVNEKTRQLMRETKGLIDALV 579

Human   523 TSINHALDAGKCEDKSVENAVCVLRNLSYRLYDEMPPSALQRLEGRGRRDLAGAPPGEVVGCFTP 587
            ..|...:...|.|:|.|||.|||||||||::|:|:|||...||:|..|..  .:...|.:|||||
Zfish   580 GYIQKCVVDSKVEEKGVENCVCVLRNLSYQVYNEIPPSIASRLDGPRRAQ--SSSKAEPIGCFTP 642

Human   588 QSRRLRELPLAADALTFAEVSKDPKGLEWLWSPQIVGLYNRLLQRCELNRHTTEAAAGALQNITA 652
            .|::.:|.. ..|..||.|||:.||.:||||.|:|:.|||::|.|||:|..|.||||||||||||
Zfish   643 NSKKAKERK-NQDLTTFTEVSRTPKDIEWLWHPKIIELYNQVLTRCEINSTTREAAAGALQNITA 706

Human   653 GDRRWAGVLSRLALEQERILNPLLDRVRTADHHQLRSLTGLIRNLSRNARNKDEMSTKVVSHLIE 717
            ||:|||.:||.:||||.|:|..:||.::|....:||||||.:|||||:.::|::|:||||:.|:.
Zfish   707 GDKRWASILSLVALEQNRMLPVILDLLKTDKDLELRSLTGFLRNLSRHTKDKNDMATKVVNTLVL 771

Human   718 KLPGSVGEKSPPAEVLVNIIAVLNNLVVASPIAARDLLYFDGLRKLIFIKKKRD-SPDSEKSSRA 781
            |||....:|.|.::|:|||...|||||..|.:||||:.||||||||..||...| |||..|:::|
Zfish   772 KLPADGRQKQPSSDVVVNICGALNNLVTGSMLAARDITYFDGLRKLFEIKNNHDNSPDKLKAAKA 836

Human   782 ASSLLANLWQYNKLHRDFRAKGYRKEDFL 810
            |.::|:|::||.|||:|::.||:.||.||
Zfish   837 AVTVLSNMFQYKKLHKDYKEKGFEKEAFL 865

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PKP3	NP_001289958.1	armadillo repeat	336..361	CDD:293788	14/24 (58%)
		ARM	365..405	CDD:214547	25/39 (64%)
		armadillo repeat	369..405	CDD:293788	24/35 (69%)
		ARM	407..447	CDD:214547	23/39 (59%)
		armadillo repeat	411..445	CDD:293788	19/33 (58%)
		armadillo repeat	464..500	CDD:293788	19/35 (54%)
		armadillo repeat	508..549	CDD:293788	23/40 (58%)
pkp3a	NP_001038745.1	armadillo repeat	393..418	CDD:293788	14/24 (58%)
		ARM	422..462	CDD:214547	25/39 (64%)
		armadillo repeat	426..462	CDD:293788	24/35 (69%)
		Arm	464..504	CDD:425727	23/39 (59%)
		armadillo repeat	468..502	CDD:293788	19/33 (58%)
		armadillo repeat	508..557	CDD:293788	27/48 (56%)
		armadillo repeat	717..753	CDD:293788	18/35 (51%)
		armadillo repeat	763..797	CDD:293788	16/33 (48%)
		armadillo repeat	805..844	CDD:293788	21/38 (55%)