DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PKP3 and pkp3

DIOPT Version :9

Sequence 1:	NP_001289958.1	Gene:	PKP3 / 11187	HGNCID:	9025	Length:	812	Species:	Homo sapiens
Sequence 2:	XP_004913456.1	Gene:	pkp3 / 100498319	XenbaseID:	XB-GENE-489317	Length:	819	Species:	Xenopus tropicalis

Alignment Length:	858	Identity:	495/858 - (57%)
Similarity:	598/858 - (69%)	Gaps:	122/858 - (14%)

- Green bases have known domain annotations that are detailed below.

Human    27 RPEAGVCSLALPSDLQLDRRGAEGPEAERLRAARVQEQVRARLLQLGQQPRHNGAAEPEPEAETA 91
            :|...:.|||||:|.|||||..:  |:...|.|||||||||:|:|     :.:.|......:.:.
Frog    12 QPRNDITSLALPTDSQLDRRLRD--ESLVQRNARVQEQVRAKLMQ-----KTHTAPRVSSNSNSY 69

Human    92 RGTSRG-------QYHTLQAGFSSRSQGLSGD------KTSGFRPIAKPAYSP-----ASWSSRS 138
            ..:|.|       ||.|..|.:|||||.||.:      :|||        ||.     :.:||||
Frog    70 SVSSYGDVFLPRTQYGTGSASYSSRSQVLSSEPRMSAVRTSG--------YSTGGGMRSGYSSRS 126

Human   139 AVDLSCSRRLSSAHNGGSAFGAAGYGGAQPTPPMPTRPVSFHERGGVGSRADYDTLSLRSLRLGP 203
            |||:..::|:|.|              :|......|||.||||: ...:|.||||:||||||:|.
Frog   127 AVDVGGTQRISVA--------------SQQRSYATTRPTSFHEK-VYPARRDYDTMSLRSLRIGD 176

Human   204 GGLDDRYSLVSEQLEPAATSTYRAFAYERQASSSSS--------------RAGGLDWPEATEVSP 254
            |  ::||:       |...|  :|..|.||.|:||:              ..||..|.|..||:.
Frog   177 G--EERYN-------PGTAS--QASVYGRQISTSSAGPMLQRSLSGNIGQDVGGTSWVERAEVAQ 230

Human   255 SRTIRAPAVRTLQRFQSSHRSR----------------------------------GVGGAVPGA 285
            :|||||||:||||||||::|:|                                  |:|.:....
Frog   231 TRTIRAPAMRTLQRFQSTNRTRVGSVPYGTINTGSQQQMQQMQQIQQMQQMQQSSGGIGSSYVTN 295

Human   286 VLEPVARAPSVRSLSLSLADSGH-LPDVHGFNSYGSHRTL---QRLSSGFDDIDLPSAVKYLMAS 346
            ::|..:||||||    |||:||: :.::.|.:.:..:::|   ...:|||||:|:|.|||.|||.
Frog   296 MIEHNSRAPSVR----SLAESGNQVQEIRGIDMFDGNKSLMSQHSFTSGFDDMDMPMAVKNLMAP 356

Human   347 DPNLQVLGAAYIQHKCYSDAAAKKQARSLQAVPRLVKLFNHANQEVQRHATGAMRNLIYDNADNK 411
            ||||||||||||||:||||..||||||||||:|:||||||..|||||||||||||||||||.:||
Frog   357 DPNLQVLGAAYIQHRCYSDNEAKKQARSLQAIPKLVKLFNCDNQEVQRHATGAMRNLIYDNPENK 421

Human   412 LALVEENGIFELLRTLREQDDELRKNVTGILWNLSSSDHLKDRLARDTLEQLTDLVLSPLSGAGG 476
            :||||||||:|||..|.|.|||||||||||||||||||:||.|||||||..||..|||||||..|
Frog   422 IALVEENGIYELLTALEEHDDELRKNVTGILWNLSSSDNLKARLARDTLSPLTQKVLSPLSGTAG 486

Human   477 PPLIQQNASEAEIFYNATGFLRNLSSASQATRQKMRECHGLVDALVTSINHALDAGKCEDKSVEN 541
            ..:||||.||||||||||||||||||||..||||||||.||:||||:..|:||.:||.|||||||
Frog   487 SAVIQQNVSEAEIFYNATGFLRNLSSASPETRQKMRECSGLLDALVSYTNNALQSGKSEDKSVEN 551

Human   542 AVCVLRNLSYRLYDEMPPSALQRLEG--RGRRDLAGAPPGEVVGCFTPQSRRLRELPLAADALTF 604
            |||||||||||||||||||.||||||  |||     ...|:.|||||||||:|:|....||..||
Frog   552 AVCVLRNLSYRLYDEMPPSNLQRLEGGQRGR-----ITAGDTVGCFTPQSRKLKEQQQGADIATF 611

Human   605 AEVSKDPKGLEWLWSPQIVGLYNRLLQRCELNRHTTEAAAGALQNITAGDRRWAGVLSRLALEQE 669
            .|:|:||||:|.||.||||.|||||||.||||::||||||||||||||||||||.|||::|||||
Frog   612 TEISRDPKGMELLWHPQIVNLYNRLLQHCELNKYTTEAAAGALQNITAGDRRWASVLSQVALEQE 676

Human   670 RILNPLLDRVRTADHHQLRSLTGLIRNLSRNARNKDEMSTKVVSHLIEKLPGSVGEKSPPAEVLV 734
            |||||:|||:|||||:||||||||||||||:|:||||||||:||||:||||....||.|||:|||
Frog   677 RILNPVLDRLRTADHNQLRSLTGLIRNLSRHAKNKDEMSTKLVSHLLEKLPSDSSEKCPPADVLV 741

Human   735 NIIAVLNNLVVASPIAARDLLYFDGLRKLIFIKKKRDSPDSEKSSRAASSLLANLWQYNKLHRDF 799
            ||||:||||.||.|:||||::||:||.||::|||.:||.|.||::|||.|||.|:|||:||||::
Frog   742 NIIAILNNLTVAGPLAARDIVYFNGLIKLMYIKKMKDSADGEKAARAACSLLTNMWQYSKLHREY 806

Human   800 RAKGYRKEDFLGP 812
            ::|||||:|||.|
Frog   807 KSKGYRKDDFLSP 819

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PKP3	NP_001289958.1	ARM	336..447	CDD:237987	91/110 (83%)
		armadillo repeat	336..361	CDD:293788	20/24 (83%)
		armadillo repeat	369..405	CDD:293788	31/35 (89%)
		armadillo repeat	411..445	CDD:293788	27/33 (82%)
		ARM	412..550	CDD:237987	108/137 (79%)
		armadillo repeat	464..500	CDD:293788	27/35 (77%)
		armadillo repeat	508..549	CDD:293788	31/40 (78%)
		ARM	639..744	CDD:237987	87/104 (84%)
		armadillo repeat	663..697	CDD:293788	28/33 (85%)
pkp3	XP_004913456.1	Keratin_2_head	83..>138	CDD:374433	24/62 (39%)
		armadillo repeat	346..371	CDD:293788	20/24 (83%)
		Syo1_like	350..>559	CDD:240521	168/208 (81%)
		ARM	375..415	CDD:214547	33/39 (85%)
		armadillo repeat	379..415	CDD:293788	31/35 (89%)
		ARM	417..457	CDD:214547	31/39 (79%)
		armadillo repeat	421..455	CDD:293788	27/33 (82%)
		armadillo repeat	670..704	CDD:293788	28/33 (85%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	537	1.000	Domainoid score	I3139
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H5200
Inparanoid	1	1.050	859	1.000	Inparanoid score	I3975
NCBI	1	1.000	-	-
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125744at33208
OrthoFinder	1	1.000	-	-		FOG0009035
OrthoInspector	1	1.000	-	-		oto159543
Panther	1	1.100	-	-	LDO	PTHR10372
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R9240
SonicParanoid	1	1.000	-	-		X6771
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	11.190