Protein Alignment MAP4K1 and Stlk

DIOPT Version :10

• Sequence 1: XP_011524706.1
• Gene: MAP4K1 / 11184
• HGNCID: 6863
• Length: 861
• Species: Homo sapiens
• Sequence 2: NP_001036442.1
• Gene: Stlk / 3355135
• FlyBaseID: FBgn0046692
• Length: 346
• Species: Drosophila melanogaster
• Alignment Length: 325
• Identity: 89/325 - (27%)
• Similarity: 149/325 - (45%)
• Gaps: 64/325 - (19%)

Human    17 YDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKM-EPDDDVSTLQKEILILKTCRHANIVAYHGS 80
            |.||:.|..|..|.|:||.| ::...:|:|.|.| :|.:.::.|..|:|.::..:|.||......
  Fly    10 YKLLEILKNGMIGTVYKAED-INNKCLAVKKVSMDQPMEKLTLLFNEVLTVRRLQHRNINTIVSC 73

Human    81 YLWLQKLWICMEFCGAGS----LQDIYQVTGSLSELQISYVCREVLQGLAYLHSQKKIHRDIKGA 141
            :|:.|.:::..:|...|:    |:::|  |....|:.|:.:.::||..|.|:||:..:|..::..
  Fly    74 FLYKQYVYLTYKFMCFGNCEVLLKNVY--TSGFPEVAIALILKDVLSALTYIHSEHYVHGSVRAK 136

Human   142 NILIN----------------DAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPEVAAVALKG 190
            :||::                ..||.:...||.:..|...|          ||.||||....| .
  Fly   137 HILLSPRKAVLSNFSYCQSFISQGEKKTFIFGSTVGIEKEL----------YWTAPEVLYQNL-S 190

Human   191 GYNELCDIWSLGITAIELAELQPPLFDVH-----------PLRVLF----LMTKSG-----YQPP 235
            ||.|..||:|:|||..|:|....|..|..           .|:||.    |:...|     :...
  Fly   191 GYTEKIDIYSIGITCCEMANGFQPFKDTELTYMYIEKVRGSLQVLLDKNSLLENQGSLSLEHTNK 255

Human   236 RLKE----KGKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQPGLNRGLILDLLDKLKNPGK 296
            |:..    ...:|..||.|:::.|.|:|..|.:|:|:::|..:.|....     .|||:||:.|:
  Fly   256 RIARDVIVNKSFSENFHQFVELCLNKNPLSRWAASKLMTHSFLKQCRNT-----SLLDQLKDLGQ 315

Human   297  296
              Fly   316  315

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MAP4K1	XP_011524706.1	STKc_MAP4K3_like	16..274	CDD:270788	82/301 (27%)
		CNH	540..847	CDD:214481
Stlk	NP_001036442.1	PK_STRAD	7..312	CDD:270856	87/320 (27%)