DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MAP4K1 and sid1

DIOPT Version :9

Sequence 1:	XP_011524705.1	Gene:	MAP4K1 / 11184	HGNCID:	6863	Length:	873	Species:	Homo sapiens
Sequence 2:	NP_593564.1	Gene:	sid1 / 2542746	PomBaseID:	SPAC9G1.09	Length:	471	Species:	Schizosaccharomyces pombe

Alignment Length:	362	Identity:	132/362 - (36%)
Similarity:	210/362 - (58%)	Gaps:	23/362 - (6%)

- Green bases have known domain annotations that are detailed below.

Human    17 YDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPD-DDVSTLQKEILILKTCRHANIVAYHGS 80
            |.||::||.|::|.|:|||:.||||::|:|.:.:|.. ||::.:::|:.:|..|..:|::.|:|.
pombe     9 YTLLRKLGSGSFGVVWKARENVSGDIIAIKQIDLETGIDDITDIEQEVFMLSNCNSSNVIQYYGC 73

Human    81 YLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLAYLHSQKKIHRDIKGANILI 145
            ::....|||.||....||:..:.:: |.|:|..||.:.||||.||.|||.|.|||||||.||||:
pombe    74 FVDGYTLWILMEHMDGGSVSGLLKM-GRLNEQVISIILREVLYGLNYLHGQNKIHRDIKAANILL 137

Human   146 NDA-GEVRLADFGISAQIGATLARRLSFIGTPYWMAPEVAAVALKGGYNELCDIWSLGITAIELA 209
            :.: |.|:|||||::||:....:||.:|:|||:||||||..   :..|....|||||||||||:|
pombe   138 SSSTGNVKLADFGVAAQLSNAASRRHTFVGTPFWMAPEVIQ---QTSYGLAADIWSLGITAIEMA 199

Human   210 ELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLV 274
            ...||...:||:||:|.:.:|  :||:|.:  .:|..|.:|:...|..:|..|.||.::|.|..:
pombe   200 NGIPPRATMHPMRVIFEIPQS--EPPKLDD--HFSPTFRDFVSCCLDLNPNMRWSAKELLQHPFI 260

Human   275 SQPGLNRGLILDLLDKLKNPGKGPSIGDIEDEEPELPPAIPRRIRSTHRSSSLGIPDADCCRRHM 339
            ...|..:. |:.||.:.:|     .:.|..|:.     .:...|.:|.:.....|.:.:......
pombe   261 KSAGTVKD-IIPLLVQKEN-----KLFDDSDQS-----VLEETINNTLKPFEEPIAEGNADIEDW 314

Human   340 EFRKLRGMETRPPANTARLQPPRDLRSSSPRKQLSES 376
            .|..::..::....||:  .|...:.||..:::|..|
pombe   315 TFETVKKSDSTVLGNTS--IPKNSIISSQNKEELPSS 349

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MAP4K1	XP_011524705.1	STKc_MAP4K3_like	16..274	CDD:270788	114/258 (44%)
		S_TKc	17..274	CDD:214567	114/258 (44%)
		CNH	540..847	CDD:214481
sid1	NP_593564.1	STKc_MST3_like	7..279	CDD:270786	119/283 (42%)
sid1	NP_593564.1	S_TKc	9..260	CDD:214567	114/258 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48012
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010