Protein Alignment MAP4K1 and gck-2

DIOPT Version :9

• Sequence 1: XP_011524705.1
• Gene: MAP4K1 / 11184
• HGNCID: 6863
• Length: 873
• Species: Homo sapiens
• Sequence 2: NP_504721.1
• Gene: gck-2 / 179072
• WormBaseID: WBGene00022603
• Length: 829
• Species: Caenorhabditis elegans
• Alignment Length: 931
• Identity: 316/931 - (33%)
• Similarity: 471/931 - (50%)
• Gaps: 173/931 - (18%)

Human     7 DIFNR-DPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCR 70
            |:..| :|.|.|:||||:|.||||||:||||..|..|.|:|:||:|..|:.:.:|:||::::.|.
 Worm     4 DVIKRSNPADDYELLQRVGSGTYGEVYKARDIRSDSLAAVKVVKLEAGDNFAVIQQEIMVIRECS 68

Human    71 HANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLAYLHSQKKIH 135
            |.||:||.|||:...:|||.||:||.|||||||.:||.||||||::||||.|:||.|||:..|||
 Worm    69 HPNIIAYFGSYIRRDRLWIVMEYCGGGSLQDIYHLTGPLSELQIAFVCRETLRGLNYLHNMGKIH 133

Human   136 RDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPYWMAPEVAAVALKGGYNELCDIWS 200
            |||||||||::.:|:|:|||||::|||.||:.:|.||||||||||||||.|..:|||...||:|:
 Worm   134 RDIKGANILLSSSGDVKLADFGVAAQITATIGKRKSFIGTPYWMAPEVACVEKRGGYGMQCDVWA 198

Human   201 LGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAAFHNFIKVTLTKSPKKRPSA 265
            .|||||||.|.||||||:||::||:|||||||:||.||:|.:|:..||:|::..|||:||||||.
 Worm   199 TGITAIELGECQPPLFDLHPMQVLYLMTKSGYKPPHLKDKHRWTPLFHDFVRQCLTKNPKKRPSP 263

Human   266 TKML-SHQLVSQPGLNRGLILDLLDKLKN------PGKGPSIGDIEDEEPEL--------PPAIP 315
            .|:| ||..| ...|:..:..|||||:..      .....::.|:.:||.::        |.|.|
 Worm   264 EKLLTSHPFV-LGSLSARMTRDLLDKVNGAPTDVYDRMSKTVDDLTEEESDMDDAPSLLTPDAAP 327

Human   316 RRIRSTHRSSSLGIP--------DADCCRRHMEFRKLRGMETRPPANTARLQPPRDLRSSSPRKQ 372
            .||         |:|        ||.|..:                           .||||
 Worm   328 IRI---------GLPAHLNGLRLDARCLEQ---------------------------LSSSP--- 353

Human   373 LSESSDDDYDDVDMLNLGTWKSPKDQILSPRSRPNSQPRPPYSPAHRPSQAPSSPTPAEDTPPPL 437
             :.||:.|                      |..|.:.||......|.....|:...|..
 Worm   354 -NTSSESD----------------------RRTPTATPRSLNRGYHSERTLPAKEMPLL------ 389

Human   438 PPKPKFRSPSDEGPGSMGDDGQLSPGVLVRCASG------PPPNSPRPGPPPSTSSPHLTA---- 492
                         |..:|.|      .|:.|.:|      ....:|| .||.:..:....|
 Worm   390 -------------PDVVGGD------ALLHCGNGVIHDDDETLRAPR-APPRTLRAAQKAAAGNS 434

Human   493 ---HSEPSLWNPPSRE----LDKPPLLPPKKEKMKRKGCALLVKLFNGCPLRIHSTAAWTHPSTK 550
               .|..|:.:.||.:    ....||:|    |:....|  ..|:.:...|:|:..|:|.||.|.
 Worm   435 KNRFSSTSIASTPSEDGLTTFFGMPLIP----KVPMGAC--FSKVMDRTELKINCAASWVHPLTG 493

Human   551 DQHLLLGAEEGIFILNRNDQ-EATLEMLFPSRTTWVYSINNVLMSLSGKTPHLYSHSILGLLERK 614
            ...||.|.|:||:..:.|.. :..|..:...|.:|::...:.|.::.|.||::|.|.::.|.::.
 Worm   494 AHLLLFGTEQGIYSFDTNCMPDGNLSKIHHRRCSWMFVYADRLTAIQGNTPYVYRHDLVALTQKN 558

Human   615 ETRAGNPIAHISPHRLLARKNMVSTKIQDTKGCRACCV--AEGASSGGPFLCGALETSVVLLQWY 677
            .|...:...:..|.:.:.::..::.::.:|:|...|.|  .:||.:...|||.|:..:|.|.|||
 Worm   559 LTLKMSKNLNKIPEKYVPKRLAITVRMPETRGALQCTVKRGQGAQANSLFLCCAVRKTVHLFQWY 623

Human   678 QPMNKFLLVRQ--VLFPLPTPLSVFALLTGPGSELPAVCIGVSPGRPGKSVLFHTVRF------- 733
            .|||:|:|||.  :...:..|:..|||:....|:.|.:||||..........|:.:.|
 Worm   624 NPMNQFVLVRSEPIREDIRFPIRPFALINSRTSDFPELCIGVGQMSGSNEYQFNMINFCSSTNNS 688

Human   734 ---GALSCWLGEMSTEHRGPV-QVTQVEEDMVMVLMDGSVKLVTPEGSPVRGLRTPE---IPMTE 791
               |.|:...|.::.:....| .:.|::.|.:.......|.|     :.::|...|:   .....
 Worm   689 ELSGDLNSSYGSLADDEMLEVGSMHQIDRDTLCFSFRNKVVL-----TDLQGFERPKPSIFTFNF 748

Human   792 AVEAVAMVGGQLQAFWKHGVQVWALGSDQLLQELRDPTLTFRLLGSPRLEC--SGTISPH----- 849
            .:|.:.:|.|.:.||..:|||...|.|:...|:|.|.:..:|::|..|:..  |..:||.
 Worm   749 HIEYLHVVDGTILAFHANGVQGRDLKSNLNTQDLCDVSRLYRVIGDDRVIILRSQPMSPRNSGDT 813

Human   850 CNL-LLPGSSNSPASASRVAG 869
            |:: ||.|.:::|     :||
 Worm   814 CDVSLLMGHTDTP-----IAG 829

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MAP4K1	XP_011524705.1	STKc_MAP4K3_like	16..274	CDD:270788	161/258 (62%)
		S_TKc	17..274	CDD:214567	161/257 (63%)
		CNH	540..847	CDD:214481	85/327 (26%)
gck-2	NP_504721.1	STKc_MAP4K3_like	14..273	CDD:270788	161/258 (62%)
		S_TKc	15..273	CDD:214567	161/257 (63%)
		CNH	483..804	CDD:214481	85/325 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	144	1.000	Domainoid score	I3128
eggNOG	1	0.900	-	-		E1_KOG0576
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D209945at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102089
Panther	1	1.100	-	-	O	PTHR48012
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X579
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	9	8.780