Protein Alignment MAP4K5 and KIC1

DIOPT Version :10

• Sequence 1: XP_047286846.1
• Gene: MAP4K5 / 11183
• HGNCID: 6867
• Length: 863
• Species: Homo sapiens
• Sequence 2: NP_011970.1
• Gene: KIC1 / 856502
• SGDID: S000001144
• Length: 1080
• Species: Saccharomyces cerevisiae
• Alignment Length: 587
• Identity: 170/587 - (28%)
• Similarity: 263/587 - (44%)
• Gaps: 116/587 - (19%)

Human    20 YELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLE-PGDDFSLIQQEIFMVKECKH-CNIVAYFG 82
            ::..:.:|.|.:|.|||..||.||.:.|:|::.|: ..|:...:|:||..:...|. .||..|:|
Yeast    23 FKRTEVIGRGKFGVVYKGYNVKTGRVYAIKVLNLDSDSDEVEDVQREIQFLASLKQISNITRYYG 87

Human    83 SYLSREKLWICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANIL 147
            |||....|||.||:|.||||:.:.. .|.:.|..|..:.||.|..|..:|....:|||||.||:|
Yeast    88 SYLKDTSLWIIMEHCAGGSLRSLLR-PGKIDEKYIGVIMRELLVALKCIHKDNVIHRDIKAANVL 151

Human   148 LTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAPEVAAVEKNGGYNQLCDIWAVGITAIELG 212
            :|:.|:|||.||||||::..|..:|::..||||||||||  :.:...|:...|||::|||..|:.
Yeast   152 ITNEGNVKLCDFGVAAQVNQTSLRRQTMAGTPYWMAPEV--IMEGVYYDTKVDIWSLGITTYEIA 214

Human   213 ELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFV 277
            ...||..|:..:||:.|:.||  :||:|:|:: :|::...|:.:.|.::||:|.:|:.||...|:
Yeast   215 TGNPPYCDVEALRAMQLIIKS--KPPRLEDRS-YSTSLKEFIALCLDEDPKERLSADDLLKSKFI 276

Human   278 -AQPGLSRALAVELL-------DKVNN--------PDN------------------HAHYTEADD 308
             |......::..||:       ||..|        |:|                  .|..:.|.:
Yeast   277 RAHKATPTSILKELISRYLLFRDKNKNKYKIEGSIPENEPSKPSEAPKPSQNGGGDEAQKSIASN 341

Human   309 D---------------DFEPHA----IIRHTIRSTNRNARAE-----RTASE--INYQPFEMLSL 347
            |               ||:..:    ||.:.|   |.:|.||     .||..  .||...:..|.
Yeast   342 DNEIKRVNEGDVEMKWDFDSLSSSDYIIENNI---NLDALAEDNNEWATAQHDLFNYAYPDEDSY 403

Human   348 YI--------PVIY------------FAVDKLQFEPPLRKETEARDEMGLSSDPNFMLQWNPFVD 392
            |.        |.:|            .|.:.....|.....|.       |..|:.|:.......
Yeast   404 YFDPTSHNTRPFVYQGTTIGKGYPGTIAQNSTLNAPVTNNYTN-------SKYPSKMVAGTTNTS 461

Human   393 GANT-GKSTSKRAIPPPLPPKPRISSYPEDNFPDEEKASTIKHCPDSESRAPQILRRQSSPSCGP 456
            |.:| |..||.:.:... .||..:..: |||     :..|.::  |..:.||:|.:..||.:.|.
Yeast   462 GTHTAGPMTSSKRLESK-APKQLLELF-EDN-----EIITAEN--DVNTEAPKISKSISSLNAGN 517

Human   457 VAETSSIGNGDGISKLMSENTEGSAQAPQLPRKKDKRDFPKPAINGLPPTPKVLMGACFSKVFDG 521
            .:....|   ..||..::.|...:...|.||......::...:...||     |:...|:|...|
Yeast   518 SSRDDFI---PSISNEVNGNINNNKMRPHLPPLSSGNNYYSQSTPALP-----LLQTKFNKTSKG 574

Human   522 CP 523
            .|
Yeast   575 PP 576

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MAP4K5	XP_047286846.1	STKc_MAP4K5	10..277	CDD:270813	103/258 (40%)
		CNH	528..843	CDD:214481
KIC1	NP_011970.1	STKc_NAK1_like	21..295	CDD:270822	107/277 (39%)