Protein Alignment MAP4K5 and CDC15

DIOPT Version :10

• Sequence 1: XP_047286846.1
• Gene: MAP4K5 / 11183
• HGNCID: 6867
• Length: 863
• Species: Homo sapiens
• Sequence 2: NP_009411.2
• Gene: CDC15 / 851274
• SGDID: S000000072
• Length: 974
• Species: Saccharomyces cerevisiae
• Alignment Length: 367
• Identity: 119/367 - (32%)
• Similarity: 180/367 - (49%)
• Gaps: 47/367 - (12%)

Human    20 YELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECKHCNIVAYFGSY 84
            |.|.|.:|.|:||.||||.|.||.::.|:|.:..|..::.:.|..||.::|...|.|||.|.|..
Yeast    25 YHLKQVIGRGSYGVVYKAINKHTDQVVAIKEVVYENDEELNDIMAEISLLKNLNHNNIVKYHGFI 89

Human    85 LSREKLWICMEYCGGGSLQDIY--HVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGANIL 147
            ....:|:|.:|||..|||:.:.  ..|| |||.:......:||.||.|||.:|.:|||||.||||
Yeast    90 RKSYELYILLEYCANGSLRRLISRSSTG-LSENESKTYVTQTLLGLKYLHGEGVIHRDIKAANIL 153

Human   148 LTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAPEVAAVEKNGGYNQLCDIWAVGITAIELG 212
            |:....||||||||:..:.::..   :..||..|||||:..   |.|.:.|.|||::|.|.:|:.
Yeast   154 LSADNTVKLADFGVSTIVNSSAL---TLAGTLNWMAPEILG---NRGASTLSDIWSLGATVVEML 212

Human   213 ELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSSTFHNFVKIALTKNPKKRPTAERLLTHTFV 277
            ...||..:|......:.:....:.||     :.:|....:|:.....||..|||||::||.|.::
Yeast   213 TKNPPYHNLTDANIYYAVENDTYYPP-----SSFSEPLKDFLSKCFVKNMYKRPTADQLLKHVWI 272

Human   278 AQPGLSRALAVELLDKVNNPDNHAHYTEAD---DDDFEPHAIIRHTIRSTNRNARAERTASEINY 339
               ..:..:.|:.|:|...     .:|:||   |.||:...:   .|..:..:..|...|...|.
Yeast   273 ---NSTENVKVDKLNKFKE-----DFTDADYHWDADFQEEKL---NISPSKFSLAAAPAAWAENN 326

Human   340 QPFEMLSLYIPVIYFAVDKLQFEPPLRKETEARDEMGLSSDP 381
            |..:::                 ||  .|::...::..||.|
Yeast   327 QELDLM-----------------PP--TESQLLSQLKSSSKP 349

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MAP4K5	XP_047286846.1	STKc_MAP4K5	10..277	CDD:270813	99/258 (38%)
		CNH	528..843	CDD:214481
CDC15	NP_009411.2	Protein Kinases, catalytic domain	24..272	CDD:473864	99/258 (38%)