Protein Alignment MAP4K5 and hppy

DIOPT Version :9

• Sequence 1: NP_006566.2
• Gene: MAP4K5 / 11183
• HGNCID: 6867
• Length: 846
• Species: Homo sapiens
• Sequence 2: NP_725863.1
• Gene: hppy / 37203
• FlyBaseID: FBgn0263395
• Length: 1218
• Species: Drosophila melanogaster
• Alignment Length: 1225
• Identity: 485/1225 - (39%)
• Similarity: 620/1225 - (50%)
• Gaps: 406/1225 - (33%)

Human     8 AADILRRNPQQDYELVQRVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKEC 72
            ::||.|||||.:|||:|::|||||||||||:.:.:.||||:|:|||||.||..:|||||.|:::|
  Fly    14 SSDISRRNPQDEYELIQKIGSGTYGDVYKAKRIQSNELAAIKVIKLEPSDDIQIIQQEIIMMRDC 78

Human    73 KHCNIVAYFGSYLSREKLWICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKM 137
            :|.||:||:||||.|:|||||||:||||||||||.|||||:|:||||:|||||:||.|||:.|||
  Fly    79 RHPNIIAYYGSYLRRDKLWICMEFCGGGSLQDIYQVTGPLTEVQIAYMCRETLKGLEYLHSMGKM 143

Human   138 HRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAPEVAAVEKNGGYNQLCDIW 202
            ||||||||||||::||||||||||:|:|||||.||||||||||||||||||||:.||||||||||
  Fly   144 HRDIKGANILLTEYGDVKLADFGVSAQITATINKRKSFIGTPYWMAPEVAAVERKGGYNQLCDIW 208

Human   203 AVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSSTFHNFVKIALTKNPKKRPT 267
            |.|||||||.|||||||||||||||||||||.|:||.|.:|.|||.|||||:|.|||||||||||
  Fly   209 ACGITAIELAELQPPMFDLHPMRALFLMSKSGFKPPTLNNKDKWSPTFHNFIKTALTKNPKKRPT 273

Human   268 AERLLTHTFVAQPGLSRALAVELLDKVNNPD-NHAHYTEADDDDFE--PHAII------------ 317
            |||||.|.|| |..:|..:|.|||.|..:|: ...:|.:.|::...  |..|.
  Fly   274 AERLLQHPFV-QCEMSLRVAKELLQKYQSPNPQFYYYLDGDEESVAGVPQRIASKMTSRTNGVPA 337

Human   318 -RHTIR---STN-----RNARAERTASEINF-----DKLQFEPPLRKETEARDEMGLSSD----- 363
             .||::   :||     |::..|...|:::.     ::|:....|....:.:|.:|....
  Fly   338 QNHTLKTGMTTNSTWNERSSSPETLPSDMSLLQYIDEELKLRATLPLNNDTKDPLGAECSCSSHN 402

Human   364 -------------------------------------------------PNFMLQ---------- 369
                                                             ||.:.|
  Fly   403 GGAAGGGGGGGVGVGAGGAAANGSSSSSGGATVGTTHHQHQQHHQHHHHPNHLHQHQSHQLPQQQ 467

Human   370 --------------WNPFVDGANTGKSTSKR---AIPPPLPPKPRISSY---------------- 401
                          .:|.....::|..|:..   :....|...|.:|:|
  Fly   468 QQQSHQAAQQEHHHHHPMTSSISSGLVTANANNISSSASLASMPGLSAYLGMRSHVVGHMGMGFG 532

Human   402 -----------PEDNFPDEEKASTI---------------------KHCPDSESRAPQILRRQSS 434
                       ..|...||..|:.:                     ..|..|   |...||..|:
  Fly   533 MGLGMSNLRTTSIDADDDELVAADVAMNNAAAAVPGNGSGAGNGSGSGCSAS---AAHYLRYSSN 594

Human   435 PSCGPVAE------------------------TSSI--------------------------GNG 449
            ......|:                        ||||                          |||
  Fly   595 YRSAAAAQASQAAHPHVNSNSNSNNGHGHAPITSSISSSASSASFYNRLLLLDNSSGDAVVGGNG 659

Human   450 DGISKLMS--------------------------------------------------------- 457
            .|.|.:.|
  Fly   660 GGSSNISSSGGASSGTNGLLDKHELDALPQAATKSAGDGFSHSNSPTANSGAGATGSRDNDGPSS 724

Human   458 ----------------ENTEGSAQA---------------------------------------- 466
                            |...||:.|
  Fly   725 SNSSHLYQNLLRSSSGETPAGSSSAGNNCDYRHENNQNGLEDSPRRHSSMDQLIGLLENMGKSPR 789

Human   467 ----------------------------PQLPRKKDKRDF--PKPAINGLPPTPKVLMGACFSKV 501
                                        |..|::..||..  |:|..|||||||||.|||||||:
  Fly   790 TRSLSDGGTQDDDEAEKEAQPDLLNNTPPVPPKRSHKRRHTPPRPISNGLPPTPKVHMGACFSKI 854

Human   502 FDGCPLKINCATSWIHPDTKDQYIIFGTEDGIYTLNLNELHEATMEQLFPRKCTWLYVINNTLMS 566
            |:||||:::|..|||||:|:||:::.|.|:|||.||:||||:|.::|||||:.||||||.:.|||
  Fly   855 FNGCPLRVHCTASWIHPETRDQHLLIGAEEGIYNLNMNELHDAAIDQLFPRRTTWLYVIKDVLMS 919

Human   567 LSEGKTFQLYSHNLIALFEHAKKPGLAAHIQTHRF-------PDRILPRKFALTTKIPDTKGCHK 624
            || ||:.|||.|:|:||  |:|        ||.||       |:|::|||||||||:||||.|.:
  Fly   920 LS-GKSCQLYRHDLVAL--HSK--------QTVRFSLHMNKIPERLVPRKFALTTKVPDTKCCTQ 973

Human   625 CCIVRNPYTGHKYLCGALQSGIVLLQWYEPMQKFMLIKHFDFPLPS--------------PLNVF 675
            ||:.||||.|:||||||..|||.|:|||:|:.||||:|..::|..|              |  ||
  Fly   974 CCVTRNPYNGYKYLCGATPSGIFLMQWYDPLNKFMLLKQCEWPAISIQGGGHGCVQNGHTP--VF 1036

Human   676 EMLVIPEQEYPMVCVAISKGTESNQVVQFETINLNSASSWF----TEIGAGSQQ------LDSIH 730
            ||::.||.|||:||..:.|.  .|..::.|.||:||| |||    .|..|.:..      |..:.
  Fly  1037 EMIITPELEYPIVCTGVRKA--MNGCLKLELINMNSA-SWFHSEDLEYDAMATMVPRRDLLKVVR 1098

Human   731 VTQLERDTVLVCLDKFVKIVNLQGKLKSSKKLASELSFDFRIESVVCLQDSVLAFWKHGMQGKSF 795
            |.|:|:|.:|||....:::|.|||..|..||:.|:|:|||.::|:|||.||||||.||||||||.
  Fly  1099 VHQVEKDAILVCYGNLIQVVTLQGNPKQHKKMVSQLNFDFNVDSIVCLPDSVLAFHKHGMQGKSL 1163

Human   796 KSDEVTQEISDETRVFRLLGSDRVVVLESRPTENPTAHS----NLYILAGHENSY 846
            ::.||||||.|.:|.:||||||:||.|||:.....:..|    :||||||||.||
  Fly  1164 RNGEVTQEIKDMSRTYRLLGSDKVVALESQLLRTGSLGSEEGHDLYILAGHEASY 1218

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MAP4K5	NP_006566.2	STKc_MAP4K5	10..277	CDD:270813	209/266 (79%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	323..485		50/493 (10%)
		CNH	511..826	CDD:214481	178/345 (52%)
hppy	NP_725863.1	STKc_MAP4K3_like	25..283	CDD:270788	202/257 (79%)
		S_TKc	26..283	CDD:214567	202/256 (79%)
		CNH	869..1184	CDD:279162	167/330 (51%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	451	1.000	Domainoid score	I511
eggNOG	1	0.900	-	-		E1_KOG0576
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	901	1.000	Inparanoid score	I381
Isobase	1	0.950	-	0	Normalized mean entropy	S2065
OMA	1	1.010	-	-		QHG45812
OrthoDB	1	1.010	-	-		D209945at33208
OrthoFinder	1	1.000	-	-		FOG0001448
OrthoInspector	1	1.000	-	-		otm40262
orthoMCL	1	0.900	-	-		OOG6_102089
Panther	1	1.100	-	-	O	PTHR48012
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4905
SonicParanoid	1	1.000	-	-		X579
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.820